In order to make clear the cause of the so-called “Itai Itai” disease, we measured the amonut of heavy metals (Cd, Pb and Zn) in the urine and faeces of the patients as well as healthy men. The results obtained were as follows:
1. The urinary cadmium excretion of the patients in the hospital was found markedly in greater quantity than their contrasts (in cases of other bone diseasesr sufferers and healthy men).
2. The urinary metal excretion (Cd, Pb and Zn) of the patients and healthy men in the epidemic district was compared with that of healthy men in the contrasted district, where such a case has been never seen till now. The most marked difference was the greater cadmium excretion by the former. And in the epidemic district, the considerable amount of cadmium was found in the urine of the patients and healthy men alike.
3. The cadminm content of rice and soybean in the epidemic district was clearly greater than in the contrasted district. With lead and zinc there was not so clear a difference as with cadmium.

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The ability of the reproduction of male mice received internal exposure of ¹³⁷Cs has been observed.
For dd-strain male mice, ¹³⁷Cs was administered intraperitoneally at the rate of 8μc Cs per gram of body weight on the first group, and 4μc Cs per gram on the second group. Administered males were mated with non-treated females 0∼10, 10∼20, 20∼40, 30∼40, ………90∼100 days following the radiocesium administration. New females were mated for every 10 days at the rate of three females for one male.
By checking vaginal plug, copulation was examined every morning. From twelve to forteen days after copulation, the mated females were killed, their uteri opened, and pregnancy and litter size examined.
The results are as follows:
(1) The copulation-rate decreased from 20 to 70 days after the ¹³⁷Cs administration. Especially in the first group, the decrease rate was remarkable between 60 and 70 days after the treatment.
(2) The pregnancy-rate decreased almost in the same way as the above. In the first group, falling steadily from 10∼20 days, finally it reached zero between 60∼70 days, and then recovered gradually.
(3) The litter size showed a similar pattern with the pregnancy rate.
(4) The number of dead embrios had a tendency to increase, especially in the first group. But the type or pattern throughout this experiment did not show any systematic changes, although the ratio of dead embrios to live embrios increased significantly almost all the term in this experiment.

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The present investigation was undertaken to determine the effects of glutamic or aspartic acids on ammonia metabolism in vitro in the separated brain and liver from animals exposed to noise or cold.
The adult male rats were exposed to noise or cold, as previously mentined. Thereafter, the animals were decapitated, and the brain and liver were immediately removed. These tissues were homogenized in Tris buffer (pH 7.4) with glass homogenizers in the cold. The mixture of 2 parts of each of these homogenates and 1 part of each of these amino acids solutions was incubated at 37C for one hour. And then, the ammonia content of the reaction mixture was measured.
Under the control and the cold conditions, the addition of glutamic or aspartic acid to the homogenate of brain or liver caused a decrease in the ammonia content, but in the noise condition, caused an increase.

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In the first report I have compared the elements in soil and drink water of 14 so called long life and 7 short life villages.
This time I have analysed those of 10 long life and 12 short life villages (Table 1, 2). By their milligram equivalent ratio, I could described most clearly the difference between both villages, that is the ratio of Mg/Ca, Ca/K, Ca/Ca+Mg+K+Na, Ca-Na (Fig. 1, 3). Over again by the distributions curve of those equivalent ratio, it shows more evidently the difference both villages, such as the ratio of Mg/Ca on the lengthwise the ratio of Ca-Na on the breadthwise (Fig. 4, 5, 6).
Farther I have analysed the trace elements in soil, such as Co, Cr, Cu, Ni, Cd, and that of short life villages content always 2-3 times more than that of long life villages (Table 3).

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An experimental study was carried out for the purpose of investigating the effect of illumination upon the work efficiency and fatigue. A boy and a girl of 8 years of age served as subjects, and the experimental work (caucellation of specified letters in the test papers) was made for 40 minutes under various illumination levels. Regarding fatigue, determination of critical flicker fusion frequency and esthesiometry were made before and after the work.
Attention was also paid upon the subjective symptoms after the work.
Results:
1) The work efficiency was highest in the range from 100 to 1, 000lx.
2) Taking the out put curve and the results of flicker-test and eathesiometry into consideration, the fatigue seemed to be slightest in the above mentioned range.
3) Lower illumination level, especially under 8lx, caused marked decline of efficiency and noticeable fatigue.
4) There was noted a tendency of decrease in efficiency at the illumination level as high as 3, 000lx although the children ware rather satisfied with that level.

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