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Volume 61 (2006)
- Issue 4 Pages 393-
- Issue 3 Pages 327-
- Issue 1 Pages 3-
Volume 61, Issue 3
Displaying 1-6 of 6 articles from this issue
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Yasuhiro KOMIYA, Hiroyuki NAKAO, Yoshiki KURODA, Katsuyuki ARIZONO, Ai ...2006 Volume 61 Issue 3 Pages 327-331
Published: May 15, 2006
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSObjectives: A longitudinal study was conducted to investigate the relationships of the change in radius bone mineral density for seven years with lifestyle, body measurement data and laboratory data.
Methods: The subjects of this study were 191 female employees working in an LSI manufacturing factory in Japan. Bone mineral density was measured on the radius of their nondominant side using DXA (dual energy X-ray absorptiometry) in 1995 and 2002. Other medical examinations were performed at the same time. Multiple regression analysis was also performed with the change in radius bone mineral density as the dependent variable.
Results: As a result of the multiple regression analysis, a significant positive correlation was observed between the change in body mass index (BMI) and the change in bone mineral density among the subjects aged 30 years and over and those under 30 years. A significant positive correlation was observed between daily milk intake and the change in bone mineral density among those aged under 30 years.
A significant negative correlation was observed between daily alcohol intake and the change in bone mineral density among those aged under 30 years, and also between parity and the change in bone mineral density among those aged 30 years and over.
Conclusions: BMI, parity, daily milk intake and daily alcohol intake are considered as significant factors that contribute to a change in bone mineral density. It is necessary that the recommended timing for medical examination be set according to age, and that a well-balanced guidance be provided from young adulthood.View full abstractDownload PDF (786K) -
Comparisons between Females and MalesTamami TAKAHASHI, Sakuji KOYA, Kihachi OHSHIMA, Tetsuro YAMANISHI, Rei ...2006 Volume 61 Issue 3 Pages 332-339
Published: May 15, 2006
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSObjectives: To determine the relationship between lifestyle and hemorheology among young people, a study was conducted among healthy university students. Because few investigations have been reported on the relationship between lifestyle factors and hemorheology by gender in young people, we analyzed the effects of lifestyle on hemorheology by administering an assessment questionnaire and by measuring whole blood passage time using MC-FAN (Micro Channel array Flow ANalyzer) and hematological and blood biochemical variables for female and male university students.
Methods: The study was conducted with 40 healthy nonathlete subjects (20 females aged 19.9±1.3 years and 20 healthy males aged 20.6±1.4 years) who volunteered to participate in the study. The smoking, alcohol drinking, eating, and other habits of the subjects were investigated using a questionnaire. Blood was obtained to determine whole blood passage time and hematological and blood biochemical variables.
Results: The mean value of whole blood passage time was significantly shorter in females (43.4±5.2sec/100μl) than in males (58.2±13.6sec/100μl). The mean values of RBC, Hb, Ht, MCHC, Alb, TG, Cr, UA, K, Ca, Fe, AST and ALT were significantly lower in females than in males, and the mean value of HDL-C was significantly higher in females than in males. In females, Spearman's correlation coefficient showed a positive correlation between whole blood passage time and RBC, and a negative correlation between whole blood passage time and TG. It also showed a positive correlation between whole blood passage time and Plt, and a negative correlation between whole blood passage time and Alb in males. Among the lifestyle factors, the mean value of whole blood passage time in females who consumed salt lightly was significantly longer than that in females who consumed salt moderately. The mean value of whole blood passage time in males who liked sweets was significantly longer than that in males who were neutral to sweets.
Conclusions: The present study showed that whole blood passage time is shorter in females than in males for young people. This conforms to the pattern shown in previous studies which investigated blood passage time among the elderly and people in their prime of life. It is conceivable that females have a higher fluidity than males in all age brackets. Regarding the effects of lifestyle on hemorheology, the present study suggests that several lifestyle factors are related to whole blood passage time and their effects differ according to gender.View full abstractDownload PDF (1396K) -
Kayumi FUJIMAKI, Jun YOSHINAGA, Chiho WATANABE, Shigeko SERIZAWA, Hiro ...2006 Volume 61 Issue 3 Pages 340-347
Published: May 15, 2006
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSObjectives: The daily intake level of di (2-ethyhexyl) phthalate (DEHP) of Japanese pregnant women was estimated on the basis of the measurement of the urinary concentrations of three DEHP metabolites.
Methods: Spot urine samples were collected from 42 pregnant women who visited the gynecology division of a hospital for routine health check between June and October, 2003. The urinary concentrations of three DEHP metabolites, namely, mono (2-ethyhexyl) phthalate (MEHP), mono (2-ethy-5-hydroxyhexyl) phthalate (MEHHP), and mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) were measured by HPLC/MS/MS.
Results: The concentrations of urinary MEHP, MEOHP and MEHHP (n=40) were 3.27-39.5 (median 9.83), 1.51-41.0 (median 10.4) and 4.6-26.6 (median 10.9) μg/g cre, respectively. The ranges of the estimated daily intake of DEHP per body weight based on the MEHP, MEOHP and MEHHP concentrations (n=40) were 3.45-41.6 (median 10.4), 0.66-17.9 (median 4.55) and 1.47-8.57 (median 3.51) μg/kg/day, respectively. The maximum estimated intake level per body weight (41.6μg/kg/day) reached the Tolerable Daily Intake (TDI) level of 40-140μg/kg/day set by the Ministry of Health and Welfare (now the Ministry of Health, Labour and Welfare).
Conclusions: The health risk of DEHP exposure of our study subjects was found to be minimum from the viewpoint of the current knowledge of its risk level, although the human health effects of low-level DEHP exposure have to be studied further.View full abstractDownload PDF (1182K) -
Kimiyo UEDA, Mitsukazu ONOMICHI, Koichi HARADA, Atsushi UEDA2006 Volume 61 Issue 3 Pages 348-356
Published: May 15, 2006
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSObjectives: This study was conducted to investigate possible factors associated with the recent decrease in birth weight in Kumamoto Prefecture between 1979 and 1997.
Methods: Vital statistics on birth between 1979 and 1997 were obtained from the records of the Ministry of Health and Welfare, Japan, on the basis of which, infants were divided into low-birth weight (LBW:<2500g) group and the normal-birth-weight (≥2500g) group, and the proportions of birth and birth weights by gestational age (from 22 to 42 weeks) of both groups between 1979 and 1997 were compared.
Results: For the normal-birth-weight group, the peaks of the proportions of birth and birth weights by gestational age in 1997 shifted to early gestation, compared with the peaks in 1979. The birth weight by gestational age in 1997 decreased, compared with that in 1979 among the normal-birth-weight group, in particular, the birth weight from 37 to 40 gestational ages decreased significantly, and the mean birth weight showed a linear relationship with these gestational ages as observed in normal fetal development.
However, in the LBW group, the mean birth weight showed a small increase after 1992 and a large increase in birth weight by gestational age in the last month of pregnancy in 1997.
Conclusions: The changes in the proportions of birth and birth weights by gestational age among the normal-birth-weight group were found to be the important factors the recent decrease in birth weight. These factors might be associated with advances in medical technology and the fact that young women diet in order to slim.View full abstractDownload PDF (1269K) -
Yuki MATSUMOTO, Yasutaka OGAWA, Rie YOSHIDA, Akinori NAKATA, Hiroshi K ...2006 Volume 61 Issue 3 Pages 357-365
Published: May 15, 2006
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSObjectives: In this study, we aim to examine whether the length of sleep modifies the level of urinary 8-hydroxy-2'-deoxyguanosine (8-OH-dG).
Methods: Subjects were 146 workers who were engaged in management, clerical work, laboratory work, or business at a certain company. We obtained information on the subjects concerning gender, body mass index, drinking and smoking habits, and the lengths of habitual and previous night sleep among others using self-reported questionnaires, which were then confirmed by interview. Urine specimens were collected in the morning and those from the second or later void were used to measure 8-OH-dG and creatinine levels. The amount of 8-OH-dG normalized by creatinine content was used as the indicator of 8-OH-dG excretion (Spot Urine 8-OH-dG: SU8-OH-dG). We excluded subjects who took sleeping pills the previous night or habitually, and those whose levels were beyond the three-standard-deviation range. The subjects were then classified into three equal-sized groups according to the length of sleep, either habitual or the previous night.
Results and conclusion: (1) A long or a short previous night's sleep, drinking alcohol more than once a week, and habitual use of medicine increased SU8-OH-dG level among female subjects. (2) A short previous night's sleep and habitual smoking, and a short previous night's sleep and habitual use of medicine had interactions which increased SU8-OH-dG level among male subjects but the length of a previous night's sleep itself did not have an effect on SU8-OH-dG level. (3) The length of habitual sleep had no effect on SU8-OH-dG level.View full abstractDownload PDF (1255K) -
An Analysis in Japan and NiigataTakayuki SEINO, Hiroto NAKADAIRA, Kazuo ENDOH, Masaharu YAMAMOTO2006 Volume 61 Issue 3 Pages 366-374
Published: May 15, 2006
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSObjectives: The objectives of this study were to determine the mortality for pancreatic cancer in the 47 prefectures of Japan and to reveal the geographical distribution of the mortality and incidence for pancreatic cancer in Niigata.
Methods: Standardized mortality ratio (SMR) for pancreatic cancer in the 47 prefectures from 1998 to 2002 was calculated on the basis of the census and vital statistics of Japan. The same SMR in the 36 cities and counties in Niigata from 1995 to 2002 was calculated. These SMRs were compared with that of the national population. Then, standardized incidence ratio (SIR) for pancreatic cancer in the 36 cities and counties in Niigata from 1995 to 2002 was calculated on the basis of the Niigata Cancer Registry, compared with that of the general population of Niigata.
Results: The SMRs for pancreatic cancer for both sexes in Hokkaido, Aomori, Akita, Miyagi and Shimane were significantly higher than that of the national population (p<0.05). The SMR for males in Niigata was significantly high, whereas that for females was near the SMR of the national population. Among the 36 cities and counties in Niigata, significantly high SMRs for both sexes were observed only in Higashikanbara county; the SMRs [95% confidence interval (CI)] were 158.4 (104.4-230.5) and 172.2 (114.4-248.9) for males and females, respectively.
Conclusions: Significantly high SMRs for pancreatic cancer were observed in Hokkaido and most of the Tohoku region. A geographical clustering of pancreatic cancer in Higashikanbara county was found. Further studies are needed to clarify the determinants of the clustering.View full abstractDownload PDF (1639K)
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