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Volume 23 (1968 - 196･･･
- Issue 6 Pages 501-
- Issue 5 Pages 437-
- Issue 4 Pages 353-
- Issue 2 Pages 213-
Volume 23, Issue 6
Displaying 1-6 of 6 articles from this issue
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Yoshinori Ohtsuka1969 Volume 23 Issue 6 Pages 501-513
Published: February 28, 1969
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe present study was designed primarily in order to determine the effect of oral administration of Oil Yellow OB which had fed to rats at dietary levels of 0.75, and 0.5 per cent for three months and at 2.0, 1.0, 0.5, 0.25, and 0.1 per cent for two years. Single oral administrations was also done on mice.
Throughout the study the animals were weighed weekly and physical conditions observed. Autopsies were performed on animals which died as well as which were sacrificed. Tissues were fixed for histopathologic examinations.
Results were as follows:
1. In a single oral administration of Oil Yellow OB, the total mortality of the mice that were given the maximum doses of 3.8gm. per kilo. was 40 per cent. The LD50 value was not obtainable due to its insolubility.
Remarkable changes in liver were observed in all animals sacrificed after 10 days: the main changes observed were one or more of diffuse liver cell enlargement, excessive mitosis, and focal necrosis.
2. Rats which were fed Oil Yellow OB at 0.75 and 0.5 per cent of the diet had a marked weight loss. In the liver, irregular arrangement and enlargement of the liver cells, sometimes accompanying mitosis, were observed in the early stages, followed by massive necrosis and collapse in the later atage.
Thrombi were often observed in portal vessels.
3. In long term feeding studies, rats which were fed Oil Yellow OB in over 0.25 per cent of the diet showed high mortality, appetite loss and marked growth inhibition, whereas the dose of 0.1 per cent level produced no appreciable effect except slight growth retardstion. In the liver, marked changes were observed in doses of more than 0.25 per cent, while there were slight changes at 0.1 per cent. The main change was centrolobular necrosis which was followed by fibrosis and cirrhosis. Nodular hyperplasia of liver cells was sometimes observed, and atypical proliferation was present in one rat which was fed at a 0.25 per cent level and sacrificed at the 53rd week.Changes were also present in the heart and kidney in some cases.View full abstractDownload PDF (12501K) -
Changes of TAF Due To Muscular WorkEimatsu Takakuwa, Yoshito Ohnaka, Kazuo Saito, Tetsuo Anei, Kiichi Imo ...1969 Volume 23 Issue 6 Pages 514-518
Published: February 28, 1969
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSOur previous studies on the evaluation of mental stress by means of the TAF-test and experiments on TAF in relation to the brain waves indicated that the TAF may be a reasonable indicator of the state of central nervous activities. As to physical fatigue, the present studies have been carried out so as to know to what extent the change in TAF could be caused by muscular work.
By the use of ergometer, three kinds of muscular works (light-work for 300 minutes, heavy-work for 30 minutes and long middle-work for 120 minutes) were given to 22 healthy male students at three-day rest intervals.
Before and after the work load, the examinees were administered the TAF-test, brain-wave (α-wave) recording, knee-reflex and several other physiological function tests, and the expiratory gases were analyzed to measure the intensity of the load.
The results obtained were as follows:
1. Following the work-administration, the function of concentration maintenance (TAF-L) lowered in the heavy and long-middle works, while it increased in the light work.
2. The lowering in TAF after the work-administration significantly correlated with the volume of oxygen consumed in muscular work, that is, the greater the latter the greater the former.
3. In the extent over 650ml/min, of O2 consumption, the increase showed a significant correlation with that of the alpha-wave appearance in the brain waves.
4. The threshold value of knee-reflex significantly increased after the work-administration in all three kinds of physical loads using ergometer.View full abstractDownload PDF (555K) -
Tadao Kawarabayashi, Akihiro Kuroshima, Hidehiko Nakata, Tomie Ohno, O ...1969 Volume 23 Issue 6 Pages 519-526
Published: February 28, 1969
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSPlasma free fatty acids (FFA), triglycerides (TG) and uric acid (UA), and skinfold thickness at three sites (triceps, inferior tip of scapula and abdomen) were determined in the postabsorptive state in obese and non-obese boys of ages from 12 to 14, who were born in Hokkaido, and living in the intense cold area, Asahikawa, Hokkaido.
The subjects were selected according to Mizuno's tables for standard and obese heightweight (1968).
In obese groups skinfold thicknesses at the three sites were appreciably greater than that in non-obese group. Plasma TG level doubled in obese children as compared with that in non-obese children, while plasma FFA and UA levels were not significantly different between the groups.
There was a significant correlation between skinfold thickness at the inferior tip of the scapula or at (the triceps+the inferior tip of the scapula) /2 and plasma FFA level in obese subjects, while no such association was found in a non-obese group.View full abstractDownload PDF (829K) -
Attenuation (CUSA) Due To Postural Change and the Function of Concentration Maintenance (TAF)Eimatsu Takakuwa, Kiichi Imori, Kazuo Saito, Tadashi Takahashi, Tokuro ...1969 Volume 23 Issue 6 Pages 527-529
Published: February 28, 1969
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe present experimental studies were made to clarify the relationship between the changes of CUSA due to postural change and the lowering in TAF under exposure to variable noise as a stress stimulus. The variable noise used was composed of band noise and white noise smaller than 90 phon which randomly varied in cycle, decibel and duration.
Nine healthy male students were exposed to the unpleasant variable noise for two hours, and the TAF-test and the measurement of change of CUSA due to postural change were made both before and after the exposure.
The results obtained were as follows:
1) Exposure to variable noise caused a significant lowering in TAF-L in each examinee, as reported in our privious papers.
2) The changes of CUSA due to postural change after the exposure to variable noise increased significantly in comparison with the values before the exposure.
3) A significant correlation was observed between the lowering in TAF-L and the increase in the change of CUSA due to postural change, that is, the greater the lowering of TAF-L, the greater the incrcase of the change of CUSA.
These facts suggested that the mechanism of cerebral circulation in postural change may be put under the control of the autonomic nervous system in a stress state due to noise exposure, that is corresponding with the lowering of TAF.View full abstractDownload PDF (376K) -
Tohru Takahashi, Noriyoshi Yamashita, Masashichi Nishio1969 Volume 23 Issue 6 Pages 530-538
Published: February 28, 1969
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSIn the period from April to July, 1967, 1234 rear-end collisions occurred in Kyoto Prefecture. Injuries and circumstances of 1053 drivers of the automobiles collided from behind were investigated with the questionaire method by mail, excluding death cases and motor-cycle accidents. Recovery rate was 74%.
The results were summarized as follows:
1. Rear-end collisions accounted for more than 20% of all vehicle-to-vehicle accidents in the period, and mostly occurred while the automobiles stopped at the intersections in the urban areas. Among the drivers investigated, 32% were professional drivers.
2. More than 68% of the drivers had physical complaints due to the accidents, symptoms and signs were various, some of them appeared even after the latent period.
3. A variety of diagnosis were given and treatments were also various, indicating the lack of the therapeutic principle.
4. Rests of patients indicated by physicians were frequently (up to 31%) interrupted by the early return of the patients to their social lives. The patients often could not afford sufficient hospitalization.
Importance of socio-economical factors lying behind the traffic accidents was discussed. Necessity of medical research institution for traffic accidents, public arbitration organization and social security system for the victims of traffic accidents were emphasized.View full abstractDownload PDF (1259K) -
[in Japanese]1969 Volume 23 Issue 6 Pages 539-543
Published: February 28, 1969
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSDownload PDF (804K)
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