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Volume 23 (1968 - 196･･･
- Issue 6 Pages 501-
- Issue 5 Pages 437-
- Issue 4 Pages 353-
- Issue 2 Pages 213-
Volume 23, Issue 4
Displaying 1-8 of 8 articles from this issue
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Kenji Kobayashi1968 Volume 23 Issue 4 Pages 353-369
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSPeroxidogenic bacteria, the residential organism in the oral cavity, has been isolated from human subjects, and studied on its distribution and biological properties. The author obtained some conclusion as follows.
1. In the method of isolation using BEB agar, these organisms were residential in saliva (oral cavity) and vagina. Especially, they could be isolated from the saliva of newborns following a vaginal delivery.
2. Isolation of this organism occured in about 40% of the specimens of gastric juices.
3. Peroxidogenic bacteria could not be isolated from the feces of healthy adults. However, isolation from feces was seen in 10-30% of patients with gastrointestinal disease. The rate of detection was especially high in obstructive jaundice and infantile pseudocholera (70%).
4. Among the peroxidogenic bacteria isolated from the oral cavity and stomach, the mitis type of genus streptococcus (Bergey's manual) was discovered. On the other hand, the bile resistant streptococci were seen in a high percentage. Bile resistance was seen in most of the strains isolated from the intestine.
5. As the results of indentifying experiments of isolated bile resistant strains, a considerable difference was seen from mitis type streptococci concerning to the biochemical properties. They also disagree with the enterococcus group, no strains show agreement with those described in the section of genus streptococcus of Bergey's Manual. However, many similarities were found in these isolated strains with Aerococcus viridans described by Cowan et al. Concering to the serological reaction of Lancefield, this organism does not belong to group D.
6. For the production of H2O2 by bacteria, presence of O2 is required. As the results of studies through anaerobic culture, there appears to be an accumulation of product preceding H2O2.
7. Since the strains isolated from the oral cavity and the digestive tract have identical biological properties, peroxidogenic streptococci isolated from the intestine appear to be the same as those isolated from the oral cavity.
8. After oral administration of the isolated bacteria to animals (rabbit, rat) the corresponding organism could not be isolated from the feces or isolated transiently. After intraintestinal injection through laparotomy, the organism could be isolated from the feces transiently. From these animal experimental results and those of isolation experiments, they cannot be considered normal intestinal flora.View full abstractDownload PDF (7742K) -
Especially Alpha-waveEimatsu Takakuwa, Kazuo Saito, Tokuro Sone, Kiichi Imori, Yoshito Onak ...1968 Volume 23 Issue 4 Pages 370-373
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThis experiment was carried out to investigate the arousal states in the brain by the measurement of the brain waves, especially the alpha-wave (8∼13c/s) appearance under exposure to continuous and intermittent noise.
Sixteen healthy men of 20 to 34 years of age were exposed to white noise of 80dB (C) under three different conditions, that is, (1) continuous noise for 10 minutes, (2) regular intermittent noise of one-minute noise and one-minute rest for 19 minute periods, (3) irregular intermittent noise of one-minute noise and irregular rests for 19 minute periods. The duration of the noise exposure in the three conditions each totaled ten minutes.
Brain waves were recorded for 10 minutes before exposure to noise, during the noise administration of 10 or 19 minutes and for 10 minutes after the exposure. The changes of alpha-wave appearance between pre- and post-exposure were compared.
The results obtained were as follows:
1) The appearance of the alpha-wave decreased significantly in the ninth and tenth minutes after exposure to continuous noise.
2) Exposure to regular intermittent noise resulted in a significant decrease of the alpha-wave appearance in the latter half of the noise administration.
3) Exposure to irregular intermittent noise caused a significant decrease of the alpha-wave appearance after the first half of the noise administration.
4) Comparing regular and irregular intermittent noise, the latter brought about a stronger alpha-blocking during the noise administration, while the former showed a delayed restoration in alpha-wave appearance after exposure to noise.
These results indicate that the influences of noise as a stressor differ not only by amount of physical energy, but also by regularity of generation.View full abstractDownload PDF (2217K) -
Especially, on the experiment of the percutaneous infection with the larvae of Necator americanus (abbr. N.a.) and Ancylostoma duodenale (abbr. A.d.) on the back of the middle finger inShinichi Nagase1968 Volume 23 Issue 4 Pages 374-399
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESS1. Experiments have been conducted on the follwing percutaneous infection subject on five volunteers (Number 1-5): depositing the water containing the infective larvae of A.d. on the back of the middle finger of their right hand, and water containing the infective larvae of N.a. on the same part of their left hand. Rate of invasion of the larvae was obtained through the skin, 24.5%-62.0% by A.d. and of 31.1%-74.5% by N.a.
In recovering worms using the anthelmintic treatment, the former rate was 0%-4.2% and the latter 8.6%-65.7%.
2. Measuring the length and the width of the infective larvae of N.a. soaked in human serum at 28°C for 96 hours, and comparing them with an unsoaked case, growth and transformation of the former could not be found. Examination of their resistance to artifical gastric juice, neither could the intensification of the resistance of the former be found. Administrating the soaked larvae into the stomach of 4 volunteers (Numbers 6-9), worms by the anthelmintic treatment were not obtained.
3. Placing the larvae of A.d. into the mucoid of the small intestine which had been extracted from a puppy, and keeping it at 28°C for 96 hours, then isolating the larvae from the small intestine, growth in length and width, or transformation could not be found. Larvae of A.d. was administered into the mouth of a puppy, and after 10 days, it was isolated from the small intestine. Transformation of the middle 3rd stage larvae was perceptible.
Administering the larvae into the stomach of a volunteers (No.10), symptoms of the so-called the Wakana disease could be found. Worms were obtained by using anthelmintic treatment. The recovering rate of the worms was 64%.View full abstractDownload PDF (6648K) -
Distribution of 95Zr-95Nb among Organs Micro-autoradiography of Lung on Intratracheally Intubated Albino RatsToshiko Morishige1968 Volume 23 Issue 4 Pages 400-405
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSDistribution and excretion of 95Zr-95Nb, which was administrated subcutaneously and orally in rats, had been studied from time to time, for the same experimental period as previous reports. At this time, 95Zr-95Nb were administered to rats of the Wister strain, by intra-tracheal intubation and time trends of distribution in organs as well as excretion in urine and feces of these experimental animals were observed. In addition an autoradiography of lung was performed using the dipping technique in order to observe a finer distribution of 95Zr-95Nb in lung when administered by inrta-tracheal intubation. The results are as follows.
1) When 95Zr-95Nb were intubated into the lung, a great amount was retained in and deposited into lung 24 hours after administration and the amount of them decreased considerably after the 7th experimental day. But, it was observed that the amount of 95Zr-95Nb at any time during the experimental period of lung was greater than that for other organs. 63 days after administration, deposition ratio of 95Zr-95Nb for lung held the some level as that of bone which would be considered to be the highest affinity for 95Zr-95Nb among organs.
2) The amount of 95Zr-95Nb of tibia increased considerably for 7 days from administration and then began to decrease toward the final experimental day. The rate of decreasing radioactivity in the tibia was considerably slow after the 14th experimental day and the deposition ratio of tibia was the highest among organs excluding the lungs. Therefore, when 95Zr-95Nb was administered into the body, it was considered that bony tissue had strongest affinity of all organs.
3) After administrating 95Zr-95Nb, the largest amount was excreted in urine and especially in the feces the first 24 hours through the experimental period. And, 49.86% of 95Zr-95Nb intubated into the lung was excreted in feces until the 63th experimental day and half of the amount of them was contains in the feces excreted until 24 hours after administration. After that, the amount of 95Zr-95Nb excreted in feces suddenly decreased and difference of the amount between feces and urine gradually became less and less toward the final experimental day.
4) A micro-autoradiography of the lung at the 63th experimental day revealed the fact there were still a number of blackening spot caused by 95Zr-95Nb in the alveolar wall and some spots were also likely to be in cells in the wall.View full abstractDownload PDF (2976K) -
Sawako Kawamura1968 Volume 23 Issue 4 Pages 406-411
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSA Mass measles vaccination program by the KL method was conducted in Chiba prefecture during two separate priods; from January to March in 1967 to March in 1968.
Concerning the clinical reactions during 2 weeks after immunization with live vaccine, observations of 812 vaccinees were done by their mothers, in three areas of Chiba prefecture.
Results of mothers, observations were to be objective.
The incidence of febrile reaction (more than 37.5°C) was 10.3±4.0%, that of rash 8.9±3.8%, and that of vaccinees' manifestation of any clinical signs was 50.8±10.4%.
For the analysis of the distribution of the onset day of febrile reaction and rash, data of Chiba city was used. There, 517 vaccinees out of about twenty thousand were observed throughout two weeks and febrile reaction was recorded in 71 cases and rash in 54 cases.
According to the analysis of the result by Weibull theory, their manifestations are randomly distributed in the time course. It might be suggested that the factors which randomize the multiplication rate of vaccine virus in the host or which are randomly distributed among vaccinees, play an important role in the manifestation of clinical reactions. Further investigation, however, is required to confirm these findings.View full abstractDownload PDF (801K) -
The Morphology of Digital Volume Pulse Wave in Health and Hypertension Recorded PlethysmographicallyShigeo Koike, Hiroshi Yamaguchi, Michiko Konishi, Kenji Ikoma, Eiko Ho ...1968 Volume 23 Issue 4 Pages 412-425
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe present investigation aims at clarifying the pathogenesis of hypertension by evaluation of 11 parameters derived from geometrical analysis of finger pulse waves, which were recorded plethysmographically. 259 subjects (male 136, female 123) from 20 to 80 years were divided into 128 normotensives and 131 hypertensives and were subdivided into 23-39, 40-59, and over 60 years groups.
In normotensives, the contours of pulse waves change with advancement of age. Statistically significant age changes were observed in an increase of the relative crest time, inclination time, ratio of amplitude of dicrotic waves to peak amplitude and in the decrease of elasticity index in both sexes.
When male hypertensives are compared with the male normotensives, the statistically significant interaction betwenn age and blood pressure is observed in the relative crest time and elasticity index. The average relative crest time and elasticity index in male normotensives are significantly low in the case of relative crest time and significantly high in the case of elasticity index compared with those of hypertensives in age group of 20-39 and 40-59 respectively. The diminition of dicrotic wave in male and female hypertensives in ages from 20 to 39 suggests that the increase of peripheral resistance may be involved the pathogenesis of essential hypertension.
Over the age of 60, none of the parameters indicate a significant difference between the normal and the hypertension group.
Males and females over the age of 60 were put together and divided into five subgroups according to systolic and diastolic blood pressure. In the subjects with only systolic elevations but diastolic normal blood pressure levels, the parameters concerned with anacrotic limbs, viz. relative crest time, elasticity index, inclination time and angle of anacrotic limb, revealed similar values to those of normotensives, while other parameters derived from catacrotic limbs, such as the percentage of descending time at 1/2 or 1/4 peak amplitude, relative amplitude at 1/2 or 1/4 the distance of the diastolic phase in subjects with systolic hypertension show lower values than those of other types of hypertension. The changes of parameters concerned with anacrotic limb in elderly systolic hypertensives may reflect the decrease of elasticity in the peripheral vasculature which is common in normotensives with advancement of age, but the concave direction of the slope of the catacrotic limb in elderly sysotlic hypertensives suggests that the resistance of peripheral circulation remains at the level of normotensives.View full abstractDownload PDF (1773K) -
[in Japanese]1968 Volume 23 Issue 4 Pages 426-431
Published: October 31, 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSDownload PDF (1086K) -
1968 Volume 23 Issue 4 Pages 431
Published: 1968
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSDownload PDF (61K)
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