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Volume 41 (1986 - 198･･･
- Issue 6 Pages 871-
- Issue 5 Pages 793-
- Issue 4 Pages 723-
- Issue 3 Pages 617-
- Issue 2 Pages 539-
Volume 41, Issue 2
Displaying 1-8 of 8 articles from this issue
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I. Classification of urinary protein excretion patterns according to the quantitative analysis of the five proteinsYuuko Kubota1986 Volume 41 Issue 2 Pages 539-549
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSFive urinary proteins were analysed among the 121 inhabitants, 63 males and 58 females aged 2-86 years, of a cadmium polluted area in the Jinzu river basin. The relation between the progression of renal dysfunction and the patterns of protein excretion in urine was studied.
1) The urinary excretion of low molecular weight (LMW) proteins larger than β2-microglobulin (β2-m), such as retinol binding protein and α1-microglobulin, increased in proportion to urinary β2-m concentration. When the concentrations of β2-m in urine were over 10mg/g.cr, the excretion of intermediate molecular weight (IMW) proteins, such as albumin (Alb) and Gc-globulin, in urine increased.
2) According to the β2-m and Alb concentrations, the urinary protein excretion patterns were classified. Among the inhabitants of the cadmium polluted area, normal type: β2-m under 0.59mg/g.cr and Alb under 40mg/g.cr was 57.9%, LMW protein dominant type: β2-m over 0.59mg/g.cr and Alb under 40mg/g.cr was 26.4%, LMW and IMW protein mixed type: β2-m over 0.59mg/g.cr and Alb over 40mg/g.cr was 15.7% and IMW protein dominant type: β2-m under 0.59mg/g.cr and Alb over 40mg/g.cr was none. The glomerular dysfunction was found by analysis of creatinine clearance and serum creatinine concentrations among inhabitants showing LMW and IMW protein mixed type.
3) As age class became higher or residence time in the polluted area became longer, the rates of cases showing LMW protein dominant type or LMW and IMW protein mixed type increased in both sexes in the polluted area. The rates of the cases showing LMW and IMW protein mixed type were higher among females than males. For reference, 47 out of 49 inhabitants of a non polluted area showed normal type and all 34 itai-itai disease patients showed LMW and IMW protein mixed type.
The classification mentioned above would be useful and convenient for differentiation of the stages of renal dysfunction caused by cadmium.View full abstractDownload PDF (1474K) -
II. The changes of disc electrophoretic patterns of urinary proteins observed after a twelve year intervalYuuko Kubota1986 Volume 41 Issue 2 Pages 550-558
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSPolyacrylamide gel disc electrophoresis (E. P) of urinary proteins were tested among the 73 inhabitants, 40 males and 33 females from 17 to 86 years of age, of the Jinzu river basin. The E. P patterns of urinary proteins were estimated and compared with those analyzed twelve years ago.
1) The E. P patterns from the 40 inhabitants showed normal patterns in both years (cases remained normal pattern). The E. P patterns from the 30 inhabitants showed abnormal patterns similar to those in 1971, with the bands consisting of low molecular weight proteins (cases remained abnormal pattern). The E. P patterns from the three inhabitants changed for the worse compared with those in 1971 (cases changed for the worse). All of the cases changed for the worse were aged 50-69 years. There were no cases changed for the better.
2) The 51 inhabitants had been mainly eating rice, harvested in their own cadmium polluted paddy fields, since 1971. The 22 inhabitants had been mainly eating purchased rice since 1971. There was no difference in tendencies of the E. P. pattern changes between the two groups classified by the sort of rice eaten.
3) The urinary cadmium concentrations of the cases which remained normal pattern, the cases which remained abnormal pattern and the cases changed for the worse among the inhabitants aged over 50 years were significantly higher than those of the cases which remained normal pattern among inhabitants aged under 50 years.
In conclusion, there were no cases changed for the better on the E. P. patterns of urinary proteins and some cases changed for the worse compared with the patterns in 1971. These results would be caused primarily by the continuous pollution of the kidneys by cadmium from the stock within the body.View full abstractDownload PDF (1185K) -
Yoji Deguchi, Akira Ogata1986 Volume 41 Issue 2 Pages 559-562
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSSelenium (Se) concentrations in 253 paired samples of maternal and cord blood were determined to investigate the mother-child correlationships in the blood Se levels at birth with regard to birth weight, gestational age, parity and abortion (spontaneous and/or artificial) experience. The results are as follows.
1) No significant difference was observed in the Se levels between maternal and cord blood samples regardless of birth weight or gestational age.
2) The mother-child correlations in blood Se concentrations were positive and significantly higher in multipara than those in primipara regardless of birth weight or gestational age.
3) Abortion experience significantly decreased the mother-child correlations in primipara but not in multipara.View full abstractDownload PDF (462K) -
Takeo Nakagawa, Katsumi Yamanaka, Fumio Kobayashi, Masako Tanahashi1986 Volume 41 Issue 2 Pages 563-570
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSIn order to examine the effect of noise and vibration, a survey of 1187 housewives living along the Shinkansen Super Express railway was conducted by means of a health questionnaire (modified Cornell Medical Index).
The Shinkansen Kogai litigation was started in the survey year, and 133 plaintiffs were included as subjects. Therefore, we analyzed the different rate of complaints between plaintiffs in the Shinkansen Kogai ligitation and non-plaintiffs.
The results are as follows,
1) There is no great difference in the rate of complaints between plaintiff and non-plaintiff in the same age-group, health-condition-group and noise-vibration-group.
2) Analysis by means of quantification method (includes the item of plaintiff or non-plaintiff) makes clear that Shinkansen noise and vibration increased the average number of complaints.View full abstractDownload PDF (856K) -
Shigenori Makino, Masahide Omori, Masafumi Aoyama, Shogo Miyata1986 Volume 41 Issue 2 Pages 571-577
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe purpose of the present study is to investigate the annual changes of coefficient variations of live birth weight and proportion of live birth weight in each prefecture from 1969 to 1981. The analysis was done using vital statistics compiled by the Japanese government.
The coefficient variations of live birth weight in each prefecture have declined annually from 1969 to 1981. Reduction of the coefficient variations was related to a decrease in the proportion of newborns with live birth weight less than 2.0kg and less than 2.5kg.
Regional differences in the coefficient variations of live birth weight were recognized at the prefectural level and these regional differences were related to the percentage of low infant birth weight and high infant birth weight.View full abstractDownload PDF (889K) -
Yutaka Midorikawa, Yoshinori Itokawa1986 Volume 41 Issue 2 Pages 578-586
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSWe have investigated whether or not drinking water plays a major role in the cause of infectious diseases, especially gastrointestinal infectious diseases, in North East Thailand.
This investigation was conducted twice, each time for three months period, that is from September 1983 through December 1983 and from November 1984 through January 1985.
Since it was not easy to obtain suitable diagonostic facilities including diagnostic instruments and reagents at the Thai village, we used modified simple methods as described below, in order to identify bacteria in the water under field conditions.
1. Using test paper for identifying contamination with coliform.
2. Using polyethylene bag with powder of media for enrichment.
3. Using agar which does not need sterilization.
4. Using kits for identifying.
5. Incubating bacteria in room temperature (without incubater).
Almost all of the drinking water in the village house was contaminated with coliform.
Aeromonas hydrophila, non-01 Vibrio cholerae and Vibrio fluvialis were also isolated from drinking water in the village.
These results indicated that drinking water at Thai villages can be a couse of the gastrointestinal tracts.
At the same time, it suggests that the modified simple method applied in this investigation is a reliable technique for the identification of bacteria in drinking water.View full abstractDownload PDF (942K) -
Mitsuru Ando1986 Volume 41 Issue 2 Pages 587-592
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSIn vivo, an organic peroxide, methyl ethyl ketone peroxide (MEKP) damaged microsomal cytochrome P-450 and cytochrome P-450 peroxidase in vitamin E deficient rat livers. Dietary vitamin E protected the microsomal enzymes from MEKP damage. Phenobarbital induced liver cytochrome P-450 peroxidase and glutation S-transferase and decreased MEKP damage on microsomal enzymes. MEKP induced production of more lipid peroxides (TBARS) in liver microsomes from vitamin E deficient rats than from vitamin E supplemented rats. Cytochrome P-450 and aminopyrine demethylase from vitamin E deficient rat microsomes were damaged to a greater extent by MEKP than were those from vitamin E supplemented rat microsomes. MEKP markedly inhibited liver microsomal TMPD- and NADH-peroxidase. In vivo, adequate levels of vitamin E, NADH, and NADPH are probably necessary to provide important protection to the endoplasmic reticulum from damage by organic peroxides.View full abstractDownload PDF (718K) -
Fumio Osaka, Hitoshi Kasuga, Minoru Sugita, Hideaki Matsuki, Takeshi M ...1986 Volume 41 Issue 2 Pages 593-600
Published: June 30, 1986
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSA survey of respiratory symptoms and housing environments using ATS-DLD questionnaires (published by the Environment Agency of Japan) and measurement of Total IgE in serum according to the PRIST method was carried out from June to July, 1984 among elementary school children (766) in Suginami Ward, Tokyo. The relationship between allergic histories or housing environments (types of heaters, house structure type, use of carpets, raising of pets in the rooms, smoking habits of their mothers) of the children and the positive (300U/ml or more) proportion of their Total IgE was studied. The following results were obtained.
1. The proportion of positive Total IgE was higher for the group with allergic histories than for the group without them.
2. The proportion of positive Total IgE by heating apparatus revealed that the air conditioning group showed higher values than the group using stoves with or without chimneys, or the non-air conditioning group.
3. As for the group with allergic histories, the proportion of positive Total IgE was higher for the air conditioning group and the clean type group than for the group of stoves without chimneys.
4. The proportion of positive Total IgE was higher in cases of overlapping of air conditioning with carpets in the bedrooms, raising of pets in the rooms or smoking mothers than otherwise.
Therefore, it is desirable in the use of air conditioners not only to remove the carpets from the bedrooms and to refrain from raising pets and smoking in the rooms, but also to frequently clean the air conditioner's filter and radiator.View full abstractDownload PDF (985K)
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