巻号一覧
50 巻 (2023)
- 4 号 p. 126-
- 3 号 p. 89-
- 2 号 p. 63-
- 1 号 p. 1-
50 巻, 3 号
選択された号の論文の5件中1～5を表示しています
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解説
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山室 修2023 年 50 巻 3 号 p. 89-95
発行日: 2023/07/25
公開日: 2023/08/04
ジャーナル 認証ありThis article is based on the award lecture of the Japan Society of Calorimetry and Thermal Analysis (JSCTA) Award in 2022. Neutron scattering is a powerful experimental technique which is comprehensive with calorimetry. For the last 20 years, my group has carried out both adiabatic calorimetric and various neutron scattering experiments for the studies of various complex condensed systems. In the adiabatic calorimetry, the measurements of heat capacity and enthalpy of absorption have been carried out. In the neutron scattering, powder diffraction, inelastic scattering, and quasielastic scattering techniques have been utilized, each providing structural, vibrational/rotational excitation and relaxational information. The basic knowledge of neutron scattering and its complementarity with thermal measurements are described in the first part of the article. Then, as the examples, the hydrogen absorption and interstitial-sites occupation in palladium nanocrystals, low-energy excitations (boson peaks) in vapor-deposited simple molecular glasses, and diffusion dynamics of MOF (Metal-Organic Frameworks) based proton conductors, and intramolecular dynamics of high-entropy liquids are described along with instruments used in their experiments.抄録全体を表示PDF形式でダウンロード (1635K) -
山岸 賢司, 坂本 泰一2023 年 50 巻 3 号 p. 96-102
発行日: 2023/07/25
公開日: 2023/08/04
ジャーナル 認証ありAptamers are nucleic acid molecules that bind to target molecules with high affinity and specificity, which are obtained using a technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX). Although aptamers are being researched and developed as promising molecular-targeted therapeutic agents, the mechanism of aptamer binding to the target proteins with their high affinity and specificity is not clear. Therefore, structural and biophysical studies are important to know that, and isothermal titration calorimetry (ITC) to study the thermodynamic basis of aptamer-target protein interactions has become very important. Furthermore, physicochemical insights obtained from molecular simulation are also important. Understanding the mechanism of aptamer binding will contribute to the development of the aptamer therapeutic agents.抄録全体を表示PDF形式でダウンロード (1054K) -
早乙女 友規2023 年 50 巻 3 号 p. 103-109
発行日: 2023/07/25
公開日: 2023/08/04
ジャーナル 認証ありSmall globular proteins have a compact structure; therefore, their thermal denaturation is described using a two-state model (N⇄D). However, some protein structures exhibited an exception to the two-state mode as implied by the two endothermic peaks in the DSC thermograms, indicating the occurrence of a complicated thermal transition (nN⇄In⇄nD) at high temperatures. The detailed analysis of DSC results indicated that this irregular phenomenon in the thermal denaturation of small globular proteins could be attributed to a reversible oligomerization (RO) at high temperature. RO was significantly destabilized by a single mutation in the hydrophobic amino acid at the interface of the crystallographic oligomer in the native state. The destabilization of the RO of PSD95-PDZ3 resulted in the inhibition of the amyloid fibrils generated by the incubation at 60℃ for 1 week. Therefore, RO was hypothesized as the precursor of protein thermal aggregation, and this observation would enable us artificially control the thermal aggregation tendency of proteins.抄録全体を表示PDF形式でダウンロード (1088K) -
小門 憲太, 阿南 静佳, 佐田 和己2023 年 50 巻 3 号 p. 110-115
発行日: 2023/07/25
公開日: 2023/08/04
ジャーナル 認証ありCrystalline-state polymerization yields polymers having different structures in comparison with those yielded by a conventional solution polymerization, because of the limited mobility and arrangement of monomers. Crystalline-state polymerization can be categorized into two types, topochemical polymerization and inclusion polymerization. Based on this background, we developed a new methodology to yield a polymer. In this system, a copolymerization of a host monomer and a guest monomer occurs, therefore it can be considered as a combination of topochemical polymerization with inclusion polymerization. This new polymerization enabled to control the polymerization degree in step-growth polymerization, as well as to control the shape and network structure of a network polymer. These examples are shown in this chapter.抄録全体を表示PDF形式でダウンロード (1913K)
フロギストン
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2023 年 50 巻 3 号 p. 116-
発行日: 2023/07/25
公開日: 2023/08/04
ジャーナル 認証ありPDF形式でダウンロード (228K)
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