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Volume 17, Issue 1
Displaying 1-8 of 8 articles from this issue
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Isamu Narabayashi, [in Japanese], [in Japanese], [in Japanese], [in Ja ...1977 Volume 17 Issue 1 Pages 1-10
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSChest scintigraphy with 67Ga-citrate was studied in 310 cases of primary lung cancer. Positive images were obtained in 83% of 247 untreated patients with primary lung cancer.
The rates of positive delineation differ somewhat according to histologic types. The larger lesions (4 cm or larger in diameter) had a higher percentage of positive delineation, while the smaller lesions had a lower percentage.
In 63 irradiated cases of primary lung cancer, the rate of 67Ga-concentration was influenced by dose of irradiation.
The scintillation camera was connected by on-line with a computer.
Computer processing of images was a very useful technique in quantitative analysis of 67Ga-accumulation.
The Mechanism of 67Ga-accumulation was examined in the tissue of resected primary lung cancer. It was suggestive that Cyclic AMP phosphodiesterase is one of the 67Ga-binding protein in tumor of positive delineation.
67Ga -scintigraphy in primary lung cancer should be proved to be helpful in assessing the extent of disease before irradiation or surgery.View full abstractDownload PDF (12799K) -
Takeo Ichiyoshi1977 Volume 17 Issue 1 Pages 11-19
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSFor the purpose of clarifying the mechansm of altered metabolism of steroid hormones in tumor-bearing animals, Δ4-steroid hydrogenase activity in the livers of female SD strain rats, which were treated with intratracheal administration of benzpyren, was examined for nine months.
Rats were divided into four groups as follow:
1) normal group, 2) benzpyren group (intratracheal infusion of 10mg benzpyren), 3) benzpyren and prednisolone group (0.25mg per 100 ml of drinking water ad libitum), and 4) benzpyren and xylitol group (one % xylitol in drinking water ad libitum).
Δ4-steroid hydrogenase activity was determined according to the modified procedure of Tomkins' method using 3 H-corticosterone as substrate.
In this experiment, following results were obtained.
1) Δ4-steroid hydrogenase activity in the livers of malignant lung tumor developing rats was significantly decreased.
On the other hand, in benzpyren treated but tumor non-bearing rats, the enzym activity was remained in its normal level.
2) In the group which was treated with additional use of prednisolone, development of the histologically malignant lung tumors was accelerated.
3) It was suggested that by the combined use of xylitol after the administration of carcinogenic substance, the development of malignant tumor was delayed.
4) Throughout the experiments, the existance ofΔ4-steroid-hydrogenase suppressing factors in tumor-developing rats was suggested, and it was also suggested that high level of plasma glucocorticoids might accelerate the tumor incidence.View full abstractDownload PDF (6845K) -
Tsutomu TAKAHASHI, Kunihisa HASHIMOTO, Yasuyuki NAGASHIMA1977 Volume 17 Issue 1 Pages 21-29
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIn order to find the causes for the recurrence and/or metastasis after removal of human lung cancer, the microscopic metastasis was examined histologically in the seemingly unaffected areas of the lungs in primary lung cancer patients. In fifty five of 116 cases (47%), microscopic metastases were found in the areas which looked normal. These micrometastases were localized in 22 cases and were disseminated in 33 cases. The sites where tumor cells were growing were identified in lung tissue such as in the blood vessels, lymphatics and aerial spaces, although it was difficult to identify in a few cases. The incidence of microscopic metastases was significantly lower in the lungs of the group in which the diameter of tumor was smaller than 3cm, than those in which the diameter was larger than 3cm. In addition there was a significant decrease in the rate of microscopic spreads in the specimens without lymph node involvement as compared to those with lymph node involvement. The rate of postoperative recurrence and/or metastases was significantly high in the cases with micrometastasis as compared to those without, suggesting that most of the microscopic spreads would become distinct tumors in time.View full abstractDownload PDF (4694K) -
With a Special Reference to Histological Features and Intrapulmonary SpreadingTetsuro KODAMA, Yukio SHIMOSATO, Akira SUZUKI, Keiichi SUEMASU, Shichi ...1977 Volume 17 Issue 1 Pages 31-45
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSSmall cell carcinomas seen at National Cancer Center Hospital during the period from 1962 through 1975 were reviewed. Among 35 surgically resected tumors, there were 6 tumors of oat cell type, 24 of intermediate cell type and 5 others. And in 110 autopsy cases, 53 were of oat, cell type, 47 of intermediate cell type and 8 unclassified. Some of intermediate cell type revealed areas with other histologic features, such as squamous and glandular. The transition between oat cell type and intermediate cell type was noted frequently even within a single tumor.
Small cell carcinoma grew often along the bronchial wall, particularly beneath the epithelium and along the submucosal lymphatics, resulting in diffuse thickening of the lining of the major bronchi. At the periphery of the lung, they grew within alveolar spaces without destroying the alveolar architectires. Gross features of small cell carcinoma of intermediate cell type with squamous cell or glandular differentiation resembled those of poorly differentiated squamous cell or adenocarcinoma, respectively. Prognosis of patients with these tumors was better than that of patients with oat cell type. Based on histological characteristics, gross features and prognosis, subclassifi cation of small cell carcinoma is proposed.View full abstractDownload PDF (18406K) -
Mitsushige Nakamura, Yukio Shimosato, Toru Kameya, Taisuke Matsumoto, ...1977 Volume 17 Issue 1 Pages 47-57
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSTwo cases of bronchial gland “mixed tumor” of the salivary gland type were found among 683 cases of the pulmonary tumors resected surgically during the past 13 years at National Cancer Center Hospital. Histologically, one case showed typical features of “benign mixed tumor” of the salivary gland type, and another revealed those of “malignant mixed tumor”. The former was present in the peripheral lung parenchyma as a well defined nodular mass, and the latter apparently arose from the wall of left B 10 b+c, growing endobronchially as a branching ployp. Ultrastructurally, both cases were characterized by the presence of neoplastic myoepitheilial cells, indicating bronchial gland origin. No Metastases were detected in lymph nodes or distant organs in both cases. Both cases are alive with no evidence of tumor recurrence 26 and 53 months after surgery, respectively. Five authentic cases reported in the literature were reviewed. Together with prognosis of the reported cases and our experienke from “mixed tumor” of the salivary gland, we concluded that these tumors should be treated as a potentially malignant tumor, even though they looked benign histologically, as other types of low grade malignant bronchial gland tumor.View full abstractDownload PDF (20736K) -
Kinya Sawada, Seigo Fukuma, Yasuo Seki, Fumitaka Tanaka, Itsuro Ishida1977 Volume 17 Issue 1 Pages 59-67
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSTwo cases with dermatomyositis were presented and the literature was reviewed. Two undifferentiated lung cancers were of small cell type and typical symptoms of dermatomyositis such as skin erythema, decrease of muscular power and so forth were noted in these patients. Muscle biopsy, skin biopsy, electromyography and some chemical examinations including quantitative tests of serum creatine phosphokinase, serum immunoglobulins and other clinical immunological factors are necessary for the establishment of the diagnosis.
In the first patient radiotherapy wit steroid administration was effective for both lung lesions and the cutaneous manifestations of the dermatomyositis and chemothera py and steroid are presently being given for the further treatment and in the second patient with the combination of the radiotherpy, immunotherapy and steroid administration was not so effective.
Dermatomyositis in adults over 40 years of age might suggest co-existence of occult malignancy such as lung cancer, breast cancer stomach cancer and so forth and careful check-up is recommended.
The more detailed study is needed for the elucidation of the etiologic factors and of the mutual immunologic relationship.View full abstractDownload PDF (5926K) -
1977 Volume 17 Issue 1 Pages 69-73
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (379K) -
1977 Volume 17 Issue 1 Pages 75-89
Published: 1977
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSDownload PDF (2010K)
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