All issues
Volume 21 (1981)
- Issue 5 Pages 499-
- Issue 4 Pages 379-
- Issue 3 Pages 231-
- Issue 2 Pages 115-
- Issue 1 Pages 1-
Volume 21, Issue 1
Displaying 1-14 of 14 articles from this issue
- |<
- <
- 1
- >
- >|
-
Makoto Kimura, Nobuaki Nakajima, Kazushige Hayakawa, Atsushi Okazaki, ...1981 Volume 21 Issue 1 Pages 1-7
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSOut of 521 cases of primary lung cancer treated during the period from April 1959 through December 1977, 73 cases were diagnosed as large cell carcinoma. They were reclassified as undifferentiated epidermoid carcinoma, undifferentiated adenocarcinoma, “large cell carcinoma” and giant cell carcinoma by a new classification.
About 74% of them were advanced in clinical stage and metastases to the brain were seen in 32% of undifferentiated adenocarcinoma cases.
Radiographically undifferentiated epidermoid carcinoma often revealed a hilar mass and atelectasis, and undifferentiated adenocarcinoma often showed peripheral mass and pleural effusion. “Large cell carcinoma” revealed mediastinal involvement most frequently.
Radiation effect was better in undifferentiated epidermoid carcinoma and “Large cell carcinoma ” than in undifferentiated adenocarcinoma. There was little difference among them in prognosis, except for giant cell carcinoma.
Large cell carcinoma should be classified by a new classification, but giant cell carcinoma is to be individually classified.View full abstractDownload PDF (8098K) -
Ryuichi YAMADA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...1981 Volume 21 Issue 1 Pages 9-15
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe experienced 8 central type early stage lung cancer cases from January 1976, including 3 which were inoperable because of other disease. Six cases are still alive and are clinically tumor-free. Of these 3 underwent surgery, one of which underwent lobectomy only, Three of the remaining 5 cases did not undergo surgical resction of the lesion. Of extreme interest is the fact that in two cases which received no therapy, and who only underwent several biopsies for diagnosis, the tumor disappeared and could not be detected by transbronchial biopsy, brushing or sputum cytology. In one of these cases, squamous cell carcinoma was diagnosed, located at the orifice of left B3. The patient underwent right lower lobectomy. Postoperative procedures revealed the disappearence of the left B3 tumor. In the other case, a tumor was recognized at the bifurcation of left B8 and B9+10 and squamous cell carcinoma was diagnosed. On the basis of X-ray findings and biopsies which strongly suggested adenocarcinoma, he received right upper lobectomy, but the resected specimen revealed TB. Subsequently the tumor in the left lower lobe bronchi was observed to have disappeared.
We therefore consider that in cases of central type lung cancer which are thought to be early stage and in which surgery is not indicated, non-invasive techniques such as transfibroptic bronchoscopic biopsy, electrosurgery, laser photoirradiation, bronchoarterial infusion or irradiation may achieve cure, and examination of such cases may lead to the development of curative nonsurgical therapeutic strategies in cases considered to be central type early stage carcinoma of the lung.View full abstractDownload PDF (5016K) -
Koichi Yoshikawa, Kazuro Iwai, [in Japanese], Yoshinori Kawabata, Masa ...1981 Volume 21 Issue 1 Pages 17-26
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPrimary tumor sites and the type of development of pleurisy were studied in 91 autopsied cases of cancerous pleurisy, of which 62 were primary lung cancer and 21 cases were of extrathoracic origin. In lung cancer, adenocarcinoma showed the highest rate of cancerous pleurisy with 80.9%, squamous cell carcinoma 35.5% and small cell carcinoma 55.5%. Tumors from various extrathoracic organs may also cause cancerous pleurisy such as tumors of the stomach, liver, kidney, ovarium, mammary gland and bone marrow. Cancerous pleurisy with unknown primary tumor site during the clinical course were found at autopsy to be lung cancer arising in the subpleural area in 4 cases, and intraabdominal cancer in 6 cases.
Carcinomatosis lymphangiosis in the lung was found significantly more frequently in cases with cancerous pleurisy than those without pleurisy and nodular dissemination of the tumor in the lung, probably as a result of hematologic metastasis, was also more frequent in cases with pleurisy than those without, and it was the same in cases of hematologic metastasis to distant organs, too. In 2 gastric, 2 ovarian and 1 renal carcinoma, direct tumor invasion through the diaphragmatic interstitial tissue from the peritoneal to the pleural side were detected microscopically. The clinical picture of cancerous pleurisies originating from the lung and those from extrapulmonary organs did not differ except for the fact that bilateral effusion appeared more early and often in the latter. The mean survival time from the onset/discovery of the disease to death was estimated to be 12.3 months in cases of cancerous pleurisy in primary lung cancer, while it was 11.0 months in cases of extrapulmonary cancers.View full abstractDownload PDF (1024K) -
Takeshi Hashimoto, Kenji Sawamura, Kiyoyuki Furuse, Toshiko Kishida, T ...1981 Volume 21 Issue 1 Pages 27-35
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFor an approach to early lung cancer detection by sputum cytology, we the studied morphological features of so called “early stage lung cancer cells” seen in the sputum specimens of 22 resected cases of “hilar type” early stage lung cancer. As a result, two types of cancer cells, “superficial cell” and “parabasal cell”, were found in these sputum specimens.
Cytological screening needs great care, because the cytoscreener is liable to mistake these cancer cells as normal epithelial cells. It has become easier to detect early lung cancer by looking for not only “superficial cells” but also “parabasal cells”.View full abstractDownload PDF (4038K) -
Shigefumi Fujimura, Atushi Yamauchi, Takashi Kondo, [in Japanese], [in ...1981 Volume 21 Issue 1 Pages 37-42
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSVariable clinical parameters were examined in 57 resected lung cancer cases surviving more than 5 years (5-year survival cases). PPD skin test reactivity (PPD) and tumor doubling time (tD) were studied and compared with those of 106 patients with resectable lung cancer (resected cases).
In 5-year survival cases, a relatively younger age distribution and increased Hb concentration in peripheral blood were noted. The PPD showed greater reactivity in 5-year survival cases, especially in adenocarcinoma cases. 5-year survival cases showed a doubling time of 210 days while that of resected cases was 106 days (P<0.01); squamous cell carcinoma in the former cases showed a tD of 264 days and in the latter 94 days (P<0.01). In the patient group with greater PPD reactivity, the tumor diameter tended to be smaller on chest x-ray film with the longer tD.These observations indicate that tumor doubling time is an important parameter in the prognosis of lung cancer patients and that an immunologic mechanism is involved in the tumor growth rate, though it may be very weak.View full abstractDownload PDF (591K) -
Kazutoshi Yokoyama, Hideo Morimoto, Shigeyasu Kaito, Taizo Shimomura, ...1981 Volume 21 Issue 1 Pages 43-49
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCarcinoembryonic antigen (CEA) in pleural effusions of various etiologies was measured by the Z-gel method in 65 patients. The patients consisted of 31 malignant and 34 benign cases (7 With tuberculosis, 17 with thoracotomy for benign disease, 8 with heart failure, 2 with pyothorax). In 31 malignant effusions, the histologic type was adenocarcinoma in 20 (65%) and undifferentiated small cell carcinoma in 4 (13%). On the assumption that a level in pleural effusion of more than 5ng/ml is “positive” as in plasma, 7.1% of malignant and 26% of benign effusions were considered to be positive. When the patients with an effusion CEA level of more than 12ng/ml were evaluated, all were malignant except for 2 cases of pyothorax.
In cases with positive plasma CEA, the effusion CEA was also positive and the level was generally higher than that in plasma. Furthermore, in cases with negative plasma CEA, the effusion CEA was generally negative except for 3 cases, including 2 cases of pyothorax with a remarkably high titer and one case of non-malignant post-thoracotomy with a slight elevation below 12ng/ml.
Although the study is inconclusive as to sensitivity and specificity, periodic measurement of CEA in pleural effusion is considered to be a useful and worthwhile means in order to evaluate the effect of local therapy and the extent or recurrence of malignancy in patients with advanced lung cancer.View full abstractDownload PDF (600K) -
K. Eguchi, N. Saijo, T. Shinkai, K. Tominaga, H. Niitani, N. Miyazawa, ...1981 Volume 21 Issue 1 Pages 51-57
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe effect of systemic chemotherapy in cases of pulmonary metastasis from uterine cancer was discussed on the basis of 58 cases admitted to our hospital. The median survival was 12.3 months but the median survival of responders was significantly higher, (14.5 months).
There was no significant difference in median survival between thoracotomy cases and chemotherapy cases. However, four thoracotomy cases survived more than five years, compared to only one 5-year survival case in the chemotherapy group.View full abstractDownload PDF (746K) -
Yutaka Ohsaki, Shosaku Abe, Yasuhiro Tsuneta, Kiyonobu Kimura, Hiroshi ...1981 Volume 21 Issue 1 Pages 59-65
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe examined the frequency of occurrence of a rod-like abnormal shadow (bronchial cast shadow) accompained with a tumor shadow in hilar type lung cancer. The bronchial cast shadow was observed more frequently in cases of upper hilar mass shadow than in the lower hilar mass shadow. This difference in frequency could be explained by the gravitational effect on bronchial secretions. As to the production of bronchial cast shadow, two mechanisms could be concerned. The first one is due to mucus plugging in the bronchi distal to the tumor formation (mucoid impaction). The second mechanism is due to intrabronchial cellular growth (cellular impaction), and is exclusively seen in small cell carcinoma.
The over-all incidence of bronchial cast shadow in hilar type lung cancer was 13.2% of 98 cases, indicating that it is not such a rare finding.
Recognition of this bronchial cast shadow is important for differential diagnosis of abnormal shadow in the lung field roentgenologically.
The two above mechanism should always be borne in mind as underlying pathophysiologic factors in the prothiction of the bronchial cast shadow observed in lung cancer.View full abstractDownload PDF (7919K) -
Tsutomu Yarita, Paul Nettesheim, [in Japanese], [in Japanese], [in Jap ...1981 Volume 21 Issue 1 Pages 67-74
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe effect of 2 retinoids, 13 cis retinoic acid and RO11-1430, on tracheal tumor development in hamsters exposed to N-nitroso-N-methylurea (NMU) was tested. Hamsters were intratracheally exposed 18 times to 1.0% NMU, twice a week, by means of the previously reported tracheal tumor induction system, before the retinoids were administered in the diet. The experimental groups studied were as follows, 150 mg RO11-1430, 75mg RO11-1430, 128mg 13 cis-retinoic acid/kg of control diet respectively, and control diet containing a Vitamin A 46 IU/g diet. As preliminary works, toxicity of retinoids, serum level of Vitamin A and early changes of tracheal epithelium induced by NMU were also studied. Although the preliminary experiments showed this experimental model was suitable for this kind of cancer prevention study, all three retinoid treated groups could not show a statistically significant inhibition of tumor development. However, we believe, that slight trends towards a reduced tumor incidence in the 150mg RO11-1430/kg diet group showed a posibility that this retinoid could be a good “chemopreventional drug” for cancer, if handled effectively. The distribution of histologic tumor types seemed to be in favor of adeno and mixed adeno-epidermoiod tumors in the group treated with also 150 mg RO11-1430. Several possible explanations for failure of the 2 retinoids to inhibit tumor development in this study were discussed.View full abstractDownload PDF (883K) -
Koji Matsumoto, Mitsuo Hirose1981 Volume 21 Issue 1 Pages 75-80
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of triple cancer confined to the respiratory system was reported. A 60 yearold man was admitted to the surgical clinic with chief complaints of cough and sputum. Past history disclosed he had resection of right middle and lower lobes for poorly differentiated epidermoid carcinoma seven years ago and partial laryngectomy for well differentiated squamous cell carcinoma two years ago.
Chest roentgenogram on admission showed a mass in the left lower lobe, which was confirmed as epidermoid carcinoma by bronchoscopic biopsy. Resection of the left lower lobe was successfully performed. A brief review of literatures was included.View full abstractDownload PDF (13133K) -
Takero YOSHIDA, Hiroyuki KUWANO, Nobuyuki HARA, Tsugio FURUKAWA, Hidey ...1981 Volume 21 Issue 1 Pages 81-85
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of carcinoma in situ of the lung was reported. Diagnosis was made on the basis of a bronchoscopic brushing specimen.
A part of the coexisting tuberculous lesion, however, was mistaken for a cancerous lesion in the pre-operative estimation of the site of the lesion. Left upper lobectomy was performed, however, histologic examination revealed carcinoma in situ at the bronchial stump, therefore pneumonectomy was eventually performed.View full abstractDownload PDF (5606K) -
Fumitaka Tanaka, Seigo Fukuma, Kinya Sawada, Yasuo Seki, Itsuro Ishida ...1981 Volume 21 Issue 1 Pages 87-92
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn unusual case of multiple pulmonary hamartomas was presented in which the histological pattern was chondromatous. Hamartomas were located in the left lingular division and the superior segment of the left lower lobe, and were treated by partial resection and lower lobectomy. This is the 31st case so far reported.View full abstractDownload PDF (7937K) -
1981 Volume 21 Issue 1 Pages 93-97
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (414K) -
1981 Volume 21 Issue 1 Pages 99-113
Published: March 31, 1981
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2060K)
- |<
- <
- 1
- >
- >|