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Volume 22 (1982)
- Issue 5 Pages 499-
- Issue 4 Pages 389-
- Issue 3 Pages 225-
- Issue 2 Pages 117-
- Issue 1 Pages 1-
Volume 22, Issue 5
Displaying 1-11 of 11 articles from this issue
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Randomized Controlled StudyH. Homma, S. Oshima, S. Watanabe, F. Itoh, I. Kimura, S. Kira, K. Konn ...1982 Volume 22 Issue 5 Pages 499-512
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA controlled randomized study was designed to evaluate the effect of Schizophyllan (SPG), an immunomodulating 0-1, 3 glucan, in 241 patients with inoperable primary lung cancer.
All patients randomly divided into two groups, the SPG group and the control group, were treated by radiotherapy and/or anticancer chemotherapy. SPG-allocated patients were given 20 mg of SPG intramuscularly twice a week for one to twenty two months.
A significant prolongation of survival time was observed in the SPG group compared with the control group (p<0.01), although there was no significant difference in rates of remission of tumor between the two groups. Moreover, considerable preventive effects of SPG against reduction of host immune responses induced by radiotherapy and/or chemotherapy or by the disease were confirmed. Side effects probably attributable to SPG were observed in 9 patients (5.5%).
It is concluded that SPG is a useful drug in the treatment of inoperable primary lung cancer when combined with radiotherapy and/or anticancer chemotherapy.View full abstractDownload PDF (1374K) -
Tetsuo Tamura, Takeyuki Numata, Shin Kawahara, Masahiro Miyai, Takumi ...1982 Volume 22 Issue 5 Pages 513-517
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBronchoalveolar lavage and subsequent bronchial brushing techniques were examined in 60 consecutive cases of lung cancer not detected by fiberoptic bronchoscopy in an attempt to improve diagnostic rate. Lavaged fluid was processed routinely for cytological examinations, and carcinoembryonic antigen (CEA) concentrations were measured concomitantly.
Lavaged fluid gave a cytological diagnosis in 63% of the patients. The positive cytology rate by brushing was 77%. Of 14 patients with negative cytology on brushing, 6 were positive in lavaged fluid. Finally, the combination of bronchoalveolar lavage and bronchial brushing gave a cytological diagnosis in 87% of the patients. Bronchoalveolar lavage was helpful in the diagnosis of patients with peripheral lung cancer.
CEA concentrations of lavaged fluid of patients with lung cancer were significantly higher than those of patients with non-malignant pulmonary diseases. It was suggested that increased CEA concentrations in lavaged fluid suggest lung cancer.View full abstractDownload PDF (431K) -
Ichita Kawamura, Masayuki Niizuma, Yoshihiro Hayata1982 Volume 22 Issue 5 Pages 519-525
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe authors discussed the significance of circulating immune complexes in 143 lung cancer cases, in relation to clinical stage and prognosis, by an enzyme immunoassay of C1q-enzyme binding substance using a glass bead method.
The average amount of immune complexes in 163 healthy persons was 4.3±7.3 microgram/dl SD. The frequency of high amounts of immune complexes findings was 46.2% in lung cancer and there was a relationship with clinical stage. The immune complexes showed higher amounts of immune complexes in advanced cases. In 33 resected cases the amounts of immune complexes decreased to normal levels in 86.9% of cases after surgery. However, in cases of recurrence the amounts of immune complexes increased. Stage III and IV cases which showed reduction of immune complexes amounts to r ormal levels after chemotherapy, radiotherapy or combined therapy showed better prognosis.View full abstractDownload PDF (702K) -
Johnson Lay1982 Volume 22 Issue 5 Pages 527-536
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDespite recent progress in diagnostic procedures for lung cancer, there are still cases in which diagnosis is difficult. The author employed the TBAC techinique in 36 cases of suspected lung cancer which were not diagnosed by ordinary fiberoptic bronchoscopic procedures or other methods, and in 7 cases of suspected lymph node involvement in the paratracheal or hilar region using a flexible retractable needle catheter was developed at the Department of Surgery, Tokyo Medical College, inserted through the instrumentation channel of the fiberoptic bronchoscope.
A definitive diagnosis was obtained in 88.9% of lung cancer cases and in 4 of lymph node involvement. However, there was no significant relationship between the positive rate, clinical stage and histologic type or tumor location. To clarify the possibility of intrabronchial bleeding due to vessel puncture, intraoperative puncture of the pulmonary artery was performed in 9 lung cancer cases, however there was no serious bleeding. Also basic studies to decide suitable puncture positions were carried out in 9 autopsied lung specimens observing the relationship between various bronchus and pulmonary vessels, and safe puncture positions were discussed.
The author concluded that TBAC is safe and is indicated to diagnose extrabronchial tumor especially in the hilum, and submucosal bronchial tumors.View full abstractDownload PDF (1006K) -
Yasushi Matsushima1982 Volume 22 Issue 5 Pages 537-549
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSHpD and Laser photoradiation for the treatment of lung cancer was teisted in a cell line (PC-7) which was derived from a human poorly differentiated adenocarcinoma of the lung and established at the Department of Surgery, Tokyo Medical College and in experimentally induced or transplanted mice tumors. Cytotoxicity tests revealed that stronger cytocidal effects were obtained using HpD with red light argon dye laser photo-radiation than with violet light krypton ion laser photoradiation. HpD alone was shown to have no cytotoxicity.
Cytocidal effects were more dependent on concentration of HpD in medium rather than on the power of laser beam.
Tests of antitumor effects utilizing WHT/Ht mice with either transplanted tumors or 20-methylcholanthrene induced tumors by argon dye laser photoradiation after administration of HpD showed strong antitumor effects in areas in which the laser beam was irradiated. Tumors sized less than 4mm in diameter disappeared after only one laser photoradiation session. The most effective time for photoradiation was between 24 hours and 72 hours after HpD administration.
The results of this study indicated that argon dye laser protoradiation after HpD administration should have clinical value in the treatment of malignant tumors especially early stage or small malignant tumors.View full abstractDownload PDF (3469K) -
Hiroshi Namio, Naoto Miyazawa, Kenji Eguchi, Toshio Ogata1982 Volume 22 Issue 5 Pages 551-559
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis retrospective study was undertaken to review the clinical significance of bronchopulmonary shunt formation in 20 primary lung cancer cases with shunt and 91 without shunt, examined by selective bronchial arteriography, in the National Cancer Center Hospital in the past 10 years.
1. The shunts were divided into 2 types; what we termed T-type and S-type. T-type shunt was formed in the tumor per se and was observed in 17 cases; 12 squamous cell carcinomas, 4 adenocarcinomas and 1 small cell carcinoma. S-type shunt was observed in a secondary inflammatory lesion adjacent to or separated from the tumor in 3 cases with squamous cell carcinoma.
2. T-type shunt group included 4 cases in stage I, 1 in stage II and 12 in stage III. Every case with S-type shunt was in stage I, and in the group without shunts, 24 were in stage I, 4 in stage II as well as 63 in stage III.
3. All 3 S-type shunt cases and 22 without shunts survived over 5 years, while no 5-year-survival was found in the T-type shunt group.
The results suggest that the bronchopulmonary shunt formation associated with primary lung cancer may be apt to be associated with squamous cell carcinoma but may have no connection with clinical stage. It seems important, however, to note the fact that in our experience the prognosis of patients with T-type shunt was very poor regardless of the histologic type.View full abstractDownload PDF (3034K) -
Takayuki Shirakusa, [in Japanese], [in Japanese], [in Japanese], [in J ...1982 Volume 22 Issue 5 Pages 561-567
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSMalignant fibrous histiocytoma (MFH) in the lung is a rare disease. We experienced two cases of MFH. One case, a 70 year-old female, showed a round tumor shadow in the right lung field. The resected specimen histologically revealed the typical storiformed pattern of spindle-shaped cells and scattered giant cells. No abnormal lesion was detected in the abdomen and extremities, and the tumor was diagnosed as MFH originating in the lung.
Another case, a 49 year-old female, showing lung metastasis of MFH originating in the retroperitoneal region, was also reported briefly.View full abstractDownload PDF (13691K) -
Masahiro Miyai, Takumi Seto, Tetsuo Tamura, Shiroh Ozawa, Yuhji Satoh, ...1982 Volume 22 Issue 5 Pages 569-573
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 63 year-old male with bronchogenic carcinoma accompanied by Eaton-Lambert syndrome and SIADH is reported. The electromyogram showed waxing phenomenon on repetitive stimulation (more than 5 per second). His myasthenic symptoms and hyponatremia improved remarkably after complete regression of the tumor by combination chemotherapy (COMP-VAN alternating chemotherapy). Follow-up radiotherapy was performed, giving 4000 rads to the site of the primary lesion and to the brain for prophylaxis. He is fully active with no symptoms at 6 months after commencement of chemotherapy.View full abstractDownload PDF (4919K) -
Yoshio Torii, Takahiko Sugiura, Akira Ikari, Masayuki Suzuki, Hiroshi ...1982 Volume 22 Issue 5 Pages 575-583
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 52 year-old man was admitted because of general fatigue and gait disturbance. The chest X-ray revealed a tumor mass in the left lower lung field. A diagnosis of small cell carcinoma of the lung was made by bronchoscopic biopsy. Investigation revealed persistent hyponatremia, and the electromyogram showed the waning phenomenon in low frequency repetitive stimulation and the waxing phenomenon in high frequency repetitive stimulation. A diagnosis of small cell carcinoma of the lung accompanied by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Eaton-Lambert syndrome was made on the basis of these laboratory data and the clinical course.
Though 60Co radiotherapy of the left lower lung field resulted in disappearance of the tumor mass on X-ray film, hyponatremia and clinical findings, he died of recurrent tumor 9 months after admission. SIADH was confirmed by a significantly elevated level of antidiuretic hormone in tumor tissue obtained at autopsy, and neurosecretorylike granules in the tumor cells observed by electron microscopy.View full abstractDownload PDF (9399K) -
1982 Volume 22 Issue 5 Pages 587-589
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (274K) -
1982 Volume 22 Issue 5 Pages 591-606
Published: December 25, 1982
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2184K)
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