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Volume 28, Issue 4
Displaying 1-14 of 14 articles from this issue
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Shinichi Yasuda, Koichiro Shimada, Yoshiyasu Sanbe, Shohei Horie1988 Volume 28 Issue 4 Pages 433-439
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe value of sialic acid in serum, lung tissues and surface of blood cells of 43 patients with lung cancer were measured by means of spectrophotometry. Results obtained were compared with those of 12 normal individuals.
Sialic acid in serum of normal individuals was 450±90μg/ml while that of lung cancer cases was 680±145μg/ml, which showed a statistically significant increase in the latter (p<0.01).
The value of serum sialic acid in lung cancer patients (in adenocarcinoma and squamous cell carcinoma) showed a statistically significant increase compared with that of the control (p<0.01).
In squamous cell carcinoma, serum sialic acid increased with the clinical stage.
In 6 lung cancer cases, the value of sialic acid in tumor was higher than in normal tissues.
The value of sialic acid on the erythrocyte cell membrane of lung cancer patients was higher than in normal cases.
The value of sialic acid in autologous rosette-forming cells was closely related to rosette formation ability.
From the above sialic acid would appear useful as a tumor marker for lung cancer.View full abstractDownload PDF (745K) -
Masami Sato, [in Japanese], Yasuki Saito, Satoshi Imai, Katsuo Usuda, ...1988 Volume 28 Issue 4 Pages 441-447
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSCytological material collected via bronchoscopy by either brushing or biopsy were employed for tissue culture in lung cancer patients. All instruments were sterilized. Using an endotracheal-cuff tube, we experienced no fungal contaminations. Contaminations was also avoided by addition of antifungal agent for the cases collected using the cuffless tube. Cancer cells were collected by transbronchoscopic brushing or biopsy. In the primary culture, cancer cell growth and attachment to the bottom were noted in 9 of 12 biopsy cases and 7 of 15 brushing cases. According to the tumor location, cell growth and attachment were noted in 10 of 14 central lung cancer cases and in one of 3 peripheral lung cancer cases.
Furthermore normal bronchial epithelium with the movement of cilia was observed in vitro through tissue culture of specimens obtained bronchoscopically for long times.View full abstractDownload PDF (4196K) -
Hidehiko Yamamoto, Masahiro Fukuoka, Shunichi Negoro, Yoko Kusunoki, K ...1988 Volume 28 Issue 4 Pages 449-455
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA study on second cancer was performed among 213 patients who wer disease-free for 2 or more years after the start of treatment for primary lung cancer by surgical resection (196 patients) or nonsurgical procedure (17 patients). Second primary cancers were observed in 11 patients, including 7 patients treated by surgical resection and 4 patients by nonsurgical treatment.
The organ in which the second cancer developed was the lung in 8 patients and the stomach in 3 patients with the former representing an excessively high-risk organ after the first lung cancer.
Histologically, the majority were squamous cell carcinoma for both primary and second (lung) cancers. All the patients were heavy smokers (cigarette index exceeding 400), and a correlation between cigarette smoking and second cancer was suggested.
Most patients remained asymptomatic before detection of second cancer on periodical examination. This finding emphasizes the importance of regular checkups after treatment of lung cancer.View full abstractDownload PDF (795K) -
Masaki Mori, Yuji Mori, Masahiko Yamagishi, Eiji Uno, Mitsuo Asakawa, ...1988 Volume 28 Issue 4 Pages 457-464
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSComputed tomography (CT) has now assumed a major role in evaluation of the mediastinum. However several potential problems exist in the use of CT for the staging of mediastinal metastases from lung cancer: CT criteria for nodal involvement by tumor rely on nodal size; nodal size alone cannot accurately predict histology; and accurate methods of measuring the size of lymph nodes have not yet been established.
The correlation of CT and pathologic evaluation of the size of mediastinal lymph nodes was investigated. CT images were retrospectively reviewed in 86 patients with lung cancer who underwent thoracotomy and mediastinal lymph node dissection. Comparing the lymph node size of CT images with the actual size after dissection, the CT diagnosis of lymph node enlargement was as follows; sensitivity 49-55%, specificity 94-96%, overall accuracy 71-79%. Neither the primary site of lung cancer or the slice thickness of CT scan significantly affected the diagnostic capability. In 13 out of 86 cases, mediastinal lymph nodes had metastasized, and the diagnostic capability of lymph node metastasis was slightly lower than that of enlargement. Non-metastatic lymph nodes in the upper mediastinum were smaller in size than those in the lower mediastinum.
These findings suggested that CT could have a more accurate diagnostic capability if several size criteria of enlargement as a function of the location of the lymph nodes were adopted.View full abstractDownload PDF (940K) -
Hirotoshi Dosaka, Masao Harada, Motoo Katabami, Hiroshi Miyamoto, Yosh ...1988 Volume 28 Issue 4 Pages 465-471
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe relationship of tumor size, status according to the TNM classification, and stage of disease to ras oncogene expression was studied in human primary lung cancer specimens immunohistochemically using monoclonal antibody rp-35 against ras p21. Adenocarcinoma and squamous cell carcinoma specimens obtained from primary sites larger than 30 mm in diameter revealed intensively positive reaction with rp-35 significantly more frequently than those with primary sites 30 mm in diameter or smaller (p<0.01). Furthermore in the TNM classification, cases with T2 (with primary sites larger than 30 mm in diameter) or T3 (with direct extension to adjacent structures) showed significantly higher reaction with rp-35 than T1 cases (with primary sites 30 mm or less in diameter) (p<0.01), although the N and M status did not correlate with ras p21 expression. These results suggest that the ras oncogene may play a significant role in tumorigenesis at the primary site and tumor growth in human lung cancer.View full abstractDownload PDF (3623K) -
Hiroshi Masuda1988 Volume 28 Issue 4 Pages 473-479
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSGlycopeptides and glycosaminoglycans were isolated from tryptic digests of the pleural effusion of cases of pleuritis carcinomatosa and cases of liver cirrhosis, and were assayed by determining the carbohydrate component. The hexose, sialic acid and uronic acid contents per milliliter of the nondialyzable materials were all higher in the pleuritis carcinomatosa cases than in liver cirrhosis. Fractionation of the glycopeptide by DEAE cellulose column chromatography yielded 3 glycopeptide fractions with a molarity of from 0.05 M to 0.2 M NaCl from both materials, and the sialic acid-rich fraction was higher than any other fraction in the material from the pleuritis carcinomatosa. Hexose was the main component and hexosamine the next in each fraction from both types of case.View full abstractDownload PDF (646K) -
Mitsutoshi Shiba, Hisami Yamakawa, Yutaka Yamaguchi, Masayuki Baba, Hi ...1988 Volume 28 Issue 4 Pages 481-489
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to increase the amount of diagnostic information of percutaneous fine needle biopsy, a new 20-gauge biopsy needle which was modified to obtain histology and cytology specimen simultaneously was employed in 33 chest disease patients. Needle biopsy under direct vision with 10 resected materials yielded 90% positive diagnosis for tumor histology. Percutaneous needle biopsy was performed in 23 chest disease cases, including 16 cases of pulmonary lesions and 7 mediastinal lesions. In 87% of cases, histology specimens were obtained by the fine needle biopsy and final diagnoses were obtained in 96% cases based on histology and cytology specimen. In one case, mild pneumothorax was observed but no other complication was noted. It was suggested this new biopsy needle increase the value of fine needle biopsy for localized chest lesions.View full abstractDownload PDF (9730K) -
Makoto Seki, Ken Nakagawa, Shigehiro Tsuchiya, Toshiki Matsubara, Iwao ...1988 Volume 28 Issue 4 Pages 491-500
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFifty one cases with lung cancer in which tracheobronchoplasty procedures were performed during the last ten years at the Cancer Institute Hospital, were studied concerning operative procedures and therapeutic problems. Since 5 of 9 absolutely non-curative resections were positive for cancer at the surgical stump, the stump-positive site and intraoperative diagnostic method were discussed. Suture insufficiency of the bronchial anastomosis occurred in 4 cases, 3 of which died of bleeding from a bronchovascular fistula. Preoperative combined therapy, that is, BAI or irradiation were given for all 4 cases, and the length of the resected main bronchus was too long in 3 of them.View full abstractDownload PDF (3562K) -
Tatsuya Saito, Hideo Kobayashi, Kanae Fukushima, Osamu Tanaka, Tadashi ...1988 Volume 28 Issue 4 Pages 501-506
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSixteen patients with mediastinal tumor were studied using magnetic resonance imaging (MRI). Cardiac gating was used in 14 of 16 patients. Repetition time (TR) was 500 msec, and the echo time (TE) was 34 msec in the remaining 2 patients. A specific signal strength (high signal intensity) was obtained in a patient with liposarcoma, in a patient with benign mediastinal mesenchymoma and in 2 patients with cysts containing gelatinous material. In other solid mediastinal tumors, the specific signal strength could not be obtained.
Mediastinal tumors were clearly defined, and mediastinal vascular structures and large airways were detected easily. However it was difficult to evaluate the invasion of the tumor into vascular structures and the chest wall.
MRI was considered useful for evaluating the extent of mediastinal tumors.View full abstractDownload PDF (9125K) -
Muneaki Waku, Hirosi Anno, Akira Koyama, Seiji Mizutani, Sinji Sisido, ...1988 Volume 28 Issue 4 Pages 507-512
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of giant localized mesothelioma of the pleura in a 57 year-old male patient. The tumor growth was retrospectively recognized during a period 5 years. The tumor finally attained an enormous size and occupied almost the entire left thoracic space. Bloody effusion was present.
CT-scan showed a huge semispherical mass with strongly contrast-enhanced irregular internal structure mixed with portions of necrosis. 67Ga-scintigram showed no positive uptake.
The tumor was successfully extirpated by panpleuropneumonectomy with entire diaphragm resection.
The tumor measured 20 by 14 cm and weighed 2000g. The pathological diagnosis was benign localized mesothelioma. No relation to asbestos pollution was recognized histologically.View full abstractDownload PDF (9700K) -
Makoto Isobe, Kiichirou Nakagawa, Yutaka Nishimura, Shinzou Edakuni, Z ...1988 Volume 28 Issue 4 Pages 513-519
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 37 year-old woman was operated under a diagnosis of primary mediastinal malignant teratoma. Total resection of the tumor was carried out, combined with resection of the left brachiocephalic vein. Post-operative histological examination revealed the presence of a component of yolk sac tumor along with teratoma by AFP staining using the PAP method, therefore, a diagnosis of teratoma with yolk sac tumor was established.
Mediastinal yolk sac tumor is an infrequent tumor, occurring predominantly inmen, and long-term survival is very rare. The present patient is doing well without recurrence at 5 years after operation. To our knowledge, this is the first female case in Japan.View full abstractDownload PDF (6752K) -
Kiyoshi Kubo, Tadaro Takahashi, Tomoyuki Tomita, Tadao Funato, Chieki ...1988 Volume 28 Issue 4 Pages 521-528
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis paper presents autopsy findings in a patient with a history of exposure to asbestos, who was clinically suspected to have malignant pleural mesothelioma. A 64-year-old male complained of severe pain in the left shoulder and left lumbar region. The chest X-ray revealed a couple of masses in the apical and S10 area of the left lung and the right pleural effusion. The biopsy finding of the mass in the basal area of the left lung and that of the right pleura revealed the same figure. This suggested contralateral dissemination of the malignant pleural mesothelioma, but was not contributory to establishment of a final diagnosis. The autopsy disclosed grayish-white thickening of the bilateral pleurae of the entire circumference and formation of solid masses in the left apical and basal areas. Histologically, the tumor and thickened parts of the pleurae showed a so-called biphasic pattern of epithelial and sarcomatous varieties. The diagnosis of malignant pleural mesothelioma was established by demonstration of hyaluronic acid in the cytoplasm of tumor cells. This case was very rare because of eosinophilia occurring concomitantly during the development of the disease and distant metastasis to the gastric wall.View full abstractDownload PDF (10255K) -
Shinji Maebeya, Osamu Nishimura, Motoyuki Takimoto, Yuuhei Goto, Yasua ...1988 Volume 28 Issue 4 Pages 529-535
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe patient was a 30-year-old woman who complained of cough and exertional dyspnea. Extensive distention was observed in her left anterior chest wall. Her chest X-ray film showed a tumor shadow in the left upper mediastinum and the trachea was shifted to the right. At two years of age she had received radiation therapy for clinically diagnosed hemangioma in the left supraclavicular portion. When she was 17 years old, exploratory thoracotomy was performed for the left upper mediastinal tumor which extended to the supraclavicular portion and the histological finding of the biopsy specimen revealed a cavernous hemangioma.
Incomplete resection was successfully performed to remove compression symptoms. The histological picture showed a pleomorphic liposarcoma. According to Cahan's criteria, this mediastinal liposarcoma may be induced by radiation therapy. Postoperative radiation therapy for the residual tumor was not effective.View full abstractDownload PDF (6828K) -
1988 Volume 28 Issue 4 Pages 537-547
Published: August 20, 1988
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1611K)
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