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Volume 35, Issue 7
Displaying 1-16 of 16 articles from this issue
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Junko Maeda, Hideo Kudou, Kohji Nanba, Noboru Yanai1995 Volume 35 Issue 7 Pages 849-855
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS -
Satoshi Yoneda, Takayuki Shirakusa, Katsunobu Kawahara, Takuo Kusano, ...1995 Volume 35 Issue 7 Pages 857-863
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe immunohistochemically investigated the expression of Bcl-2 protein in non-small cell lung carcinoma.The expression of Bcl-2 protein was detected in 7 cases of 107 adenocarcinoma (6.5%), 17 of 58 squamous cell carcinoma (29.3%), 0 of 23 adenosquamous carcinoma (0%), one of 11 large cell carcinoma (9.1%) and one of one adenoid cystic carcinoma (100%).The Bcl-2 protein was expressed significantly more highly in squamous cell carcinoma than in adenocarcinoma or adenosquamous carcinoma (p<0.001, p<0.005).The expression of Bcl-2 protein was also significantly higher in hilar type, and in early stage cases than in central type, and in advanced cases (p<0.05, p<0.05).The survival rate was better among patients with Bcl-2 positive cancers, both in the group as a whole (p<0.1) and in the group with squamous cell carcinoma (p<0.05). In the group with stage I and II squamous cell carcinoma, the prognosis of patients with Bcl-2 positive cancers was significantly better than negative cases (p<0.04).Bcl-2 protein may play a role in tumor progression and be a general prognostic factor in squamous cell carcinoma of the lung.View full abstractDownload PDF (7359K) -
Takahiko Horiguchi, Souichi Tachikawa, Eiji Munekata, Noriyuki Takeuch ...1995 Volume 35 Issue 7 Pages 865-873
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA new tumor marker for primary lung cancer was used to investigate the clinical significance of the cytokeratin 19 fragment (CYFRA 21-1).The serum level was measured in 52 patients with primary lung cancer, 38 patients with other pulmonary diseases, and 22 normal volunteers.These values were compared with values of other tumor markers (CEA, SCC, and NSE). When the cut-off value was established as 3.5 ng/ml, the positivity rate of primary lung cancer was 65%, and the false positivity rate of other pulmonary diseases was 8%.The positivity rate was the highest in squamous cell carcinoma (88. 9%) and for adenocarcinoma it was 61.5%.Immunohistochemical staining revealed uniform, intense positivity within the cytoplasm of squamous cell carcinoma.The positivity rate of lung cancer, in clinical stages I, II, MA, IIIB, and N, was 50%, 50%, 40%, 71%, and 72%, respectively.Even for early stage lung cancer, the rate was found to be high.From the ROC curve investigation results, CYFRA 21-1 is considered more sensitive and specific than CEA and SCC for all primary lung cancers and especially pulmonary squamous cell carcinomas.View full abstractDownload PDF (3470K) -
Satoshi Masada, Yoichi Nakamura, Haruhiko Nakamura, Yasushi Matushima, ...1995 Volume 35 Issue 7 Pages 875-882
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSInvestigation of the distribution pattern and structure of lymphatics in the parietal pleura is indispensable to clarify poor prognostic factors of lung cancer such as pleural dissemination and malignant pleural effusion.
Using cadavers we investigated by means of the distribution pattern of lymphatics in detail using an enzymehistochemical technique and their structure using light and both scanning and transmission electron microscopy.
Initially lymphatics arose from connective tissue just below mesothelial tissue, and though their density varied in different portions, they immediately interconnected to form a plexus.These lymphatics gradually ran into deep layers of the pleura and in the muscular part of the diaphragm connected with conduit lymphatics, which were distributed in parallel to the muscle fibers.The conduit lymphatic vessels drained into several groups in the diaphragmatic pleura:(1) towards the lower sternal portion:(2) to the boundary adjoining the intercostal pleura (3) to the junction of vertebrae and ribs:(4) to the aortic hiatus:(5) to the esophageal hiatus.Furthermore in the mediastinal pleura there was drainage into;(1) the upper and lower portions of the sternum;(2) the inferior anterior adjoining the pericardial sac:(3) the hilum of the lung;(4) the aortic hiatus:(5) the esophageal hiatus.Using scanning electron microscopy few stoma were observed in the middle of the muscular portion of the diaphragmatic pleura.View full abstractDownload PDF (8008K) -
Arata Motoyama, Michio Kono, Shuji Adachi, Masahiko Kusumoto, Eiichiro ...1995 Volume 35 Issue 7 Pages 883-890
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe employed helical CT for secondary screening of lung cancer in the last 4 years. Out of 389 cases, 49 cases required further examinations. A total of 18 malignant tumors were detected, all of which were more than 1cm in diameter, and in 17 cases, they were diagnosed by bronchoscopy or CT-guided needle biopsy. In the other case, the lesion increased in size during follow-up, and was diagnosed with open lung biopsy. Among the unconfirmed 31 cases, there were 10 cases with lesions which were less than 1cm in diameter and difficult to biopsy. None of the 10 cases increased in size during follow -up. Among the 49 cases requiring further examination, 7 lesions (14%) were unclear on fluoroscopic radiographs, and 9 lesions (18%) were unclear on conventional radiographs. In all malignant cases, the lesions were detectable on both types of radiographs.In most cases, if a lesion is too small to enable a bronchoscopic or needle biopsy, follow-up is recommended rather than open lung biopsy or thoracoscopy. The effectiveness of secondary screening for lung cancer by helical CT was unclear, because all malignant tumors detected by helical CT were detected by fluoroscopic and conventional radio-graphs.View full abstractDownload PDF (4657K) -
Takeshi Isobe, Kouzo Yamada, Fumihiro Oshita, Ikuo Nomura, Kazumasa No ...1995 Volume 35 Issue 7 Pages 891-899
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSConventional CT (10mm thick) and helical thin-slice CT (2mm thick) using high resolution images were performed to correlate the appearance of small peripheral carcinomas of the lungs with pathological features.In this study, 21 cases of resected lung carcinoma less than 1.5cm in diameter were retrospectively reviewed.Conventional CT images revealed air spaces within pulmonary nodules, irregular margins, pleural indentations, or involvement of vessels in 95% of tumors.When these findings are observed in pulmonary nodules, further examinations employing thin-slice CT should be conducted.
Characteristics observed on helical thin-slice CT images included a solid type of internal attenuation in 71%, well-defined margins in 76%, irregularly undulated margins in 76%, pleural indentations in 62%, and vascular involvement in 95%.View full abstractDownload PDF (10136K) -
Shinsuke Ito, Takahiko Sugiura, Munehiko Morishita, Atsuo Urata, Yasut ...1995 Volume 35 Issue 7 Pages 901-909
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe investigated the optimum time for initiation of G-CSF therapy in the treatment of non-small cell lung cancer with the MVP regimen.The subjects consisted of 28 patients with a post-MVP neutrophil count less than 1, 000/mm3.With the first course of MVP, G-CSF was started after the neutrophil count decreased to less than 1, 000/mm3 (arm A).With the second course of MVP, preventive G-CSF treatment was given from day 6 (arm B).Arm B showed a shorter duration of the nadir neutrophil count and the period with a count less than 1, 000/mm3, but there was no significant difference between the two arms.However, a neutrophil count of 2, 000/mm3 or more was reached significantly faster in arm B, with this count only being attained after 17 days in arm A.Post-MVP febrile neutropenia developed in 4 arm A patients and 5 arm B patients.The GCSF dose in arm A was half of that for arm B, with the difference being significant. Considering the lack of a significant preventive effect on the development of neutropenia in arm B, despite the higher G-CSF dose and the similar anti-infection effect of arm A, we concluded that arm A seemed to be a superior regimen.View full abstractDownload PDF (976K) -
Toshikazu Hirai, Mitsuhiro Kamiyoshihara, Osamu Kawashima, Keiichi End ...1995 Volume 35 Issue 7 Pages 911-916
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDuring a 14-year period, 11 patients (2.0%) including eight men and three women were diagnosed as synchronous multiple primary lung cancers in 542 lung cancer patients who were treated surgically in our hospital. All of patients in men were heavy smokers (BI 600). Nine patients had unilateral lesions and two bilateral. Histologically, the pairing of squamous cell carcinoma and adenocarcinoma was most common. Seven patients had two separate tumors classified as T1 or T2 without mediastinal or hilar lymph node metastasis. Of nine patients with unilateral tumors, six had a lobectomy, two had a bilobectomy, one had a lobectomy combined with wedge excision, and the two patients with bilateral tumors received a staged bilateral lobectomy. In conclusion, four patients survived more than two years after the resection, and one patient more than five years. Of these, four had two separate tumors classified as T1N0M0.A good prognosis can be expected by adequate surgical treatment in stage I lung cancer patients with synchronous multiple primary lesions.View full abstractDownload PDF (704K) -
Masao Nakata, Akira Kurita, Hideyuki Saeki, Shigemitu Takashima1995 Volume 35 Issue 7 Pages 917-921
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe studied the outcome of resected primary lung cancers with intrapulmonary metastases to discuss the indications for surgical treatment.
From 1985 to 1993, intrapulmonary metastases were found in 24 cases (16.9%) of 142 resected lung cancers.The 5-year survival rate of these cases was 11.4%.Cases of pT1 or 2 or pN0 or 1 showed a better outcome than those of T4 or pN2.The 5-year survival rate of 8 cases of pTl or 2 and pN0 or 1 was 28.6%.The cases with a solitary intrapulmonary metastasis had a significantly better prognosis than those with multiple intrapulmonary metastases.
We concluded that a good prognosis could be expected by surgical treatment in cases of T1 or 2 and N0 or 1 with solitary intrapulmonary metastasis.View full abstractDownload PDF (530K) -
Masashi Bandoh, Yoshiki Ishii, Satoshi Kitamura, Norio Hirota, Ryoji M ...1995 Volume 35 Issue 7 Pages 923-929
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe treated a case of involving 2 concurrent cancers, malignant mesothelioma and malignant melanoma.An 86-year-old man, complaining of dyspnea, was referred to our hospital for further examination of right pleural effusion and a lentigo on the 5th toe. The lentigo was excised and microscopic examination revealed malignant melanoma. Malignant mesothelioma was also suspected due to findings of a chest CT scan and elevated hyarulonic acid in the pleural effusion.Malignant mesothelioma was diagnosed thoracoscopic biopsy.This technique considered useful for early and definitive diagnosis of malignant mesothelioma.We also analyzed the patient's CDKN2 genotype by multiplex polymerase chain reaction, using primers of CDKN2 and β-globin.Despite chemotherapy, the patient died of respiratory failure after three months.The postmortem specimen of the mesothelioma showed deletion of the CDKN2 gene.This abnormality of the CDKN2 gene was not found in specimens from the malignant melanoma. Although we could not fully exclude the possibility of a technical failure in extraction of the DNA, we suggest that the CDKN2 gene might have been related to the oncogenesis of both cancer in this patient.View full abstractDownload PDF (7491K) -
Koji Satake, Hiroaki Kume, Kenichi Yamaki, Kenzo Takagi, Ryujiro Suzuk ...1995 Volume 35 Issue 7 Pages 931-935
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 78-year-old woman, complaining of decreased vision and a mass in her left eye, visited our hospital.A chest X-ray film showed a tumor shadow in the left upper lobe and the serological tests showed elevation of CEA. Bronchoscopic examination revealed left edemotous change in the left main bronchus and stenosis of the orifice of left B1+2. Transbronchial lung biopsy revealed well differentiated adenocarcinoma.Although cytology examination of her hydatoid was negative, the iris mass was thought to be metastatic from adenocarcinoma of the lung.There are few case reports of metastatic iris tumor from primary lung cancer, this is only the 19th case report in Japan.View full abstractDownload PDF (3487K) -
Hirohisa Hirabayashi, Tsutomu Yasumitsu, Yahiro Kotake, Katsuhiro Naka ...1995 Volume 35 Issue 7 Pages 937-942
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe curatively resected two AFP producing carcinomas of the lung, both of which resulted in a good outcome.To investigate the prognosis of AFP producing carcinoma of the lung, we reviewed 38 AFP producing carcinomas of the lung reported in Japan, and our 2 cases.Case 1 was a 55 year-old man.He was admitted with a tumor mass in the right lower lung field.Transbronchial biopsy revealed large cell carcinoma of the lung. The serum AFP level was 32, 000ng/ml.A right middle and lower bilobectomy was performed.He is disease free 11 years after the operation.
Case 2 was a 57-year-old man who complained of productive cough and sputum and was admitted with a tumor mass in the left lower lung field.Needle biopsy specimens showed well differentiated adenocarcinoma and the serum AFP level was 3, 140ng/ml.A standard left pneumonectomy was performed. He is disease free 30 months after operation.
In both cases, the pathological stage was I, and immunohistochemical study revealed carcinoma cells staining with anti-AFP serum.In Japan, 40 cases of AFP producing lung carcinoma, including our 2 cases, have been reported.Of these 38 cases were male, and only 2 cases were female.With regard to histological type, 26 cases were adenocarcinoma.Curative resection of AFP-producing lung carcinomas may result in a good outcome.View full abstractDownload PDF (7826K) -
Nanae Hangai, Takaaki Ikeda, Yoshihiro Nishimura, Hirokazu Moriyama, J ...1995 Volume 35 Issue 7 Pages 943-947
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 38-year-old male was referred because of dyspnea on exertion and persistent dry cough.The chest roentgenogram on admission showed bilateral lung masses (two in the left lower field and one in the right middle field).Laboratory findings were normal except for high levels of serum LDH and NSE.CT-guided needle biopsy revealed sarcomatous tissue.To relieve the symptoms resection of the masses in the left lower lobe and right middle and lower bilobectomy together with partial resection of the right main pulmonary artery was performed simultaneously.Pathological examination revealed that the tumor was leiomyosarcoma originating from the pulmonary artery, and that the left lung masses were metastatic.The tumor invaded the surgical stump of the right main pulmonary artery, therefore radical irradiation (50Gy) was carried out after surgery.The patient died 3 months later of local recurrence and remote metastases to the brain and othersites.View full abstractDownload PDF (8485K) -
Masahiro Mae, Takamasa Onuki, Toshinori Tanaka, Sumio Nitta, Makio Kob ...1995 Volume 35 Issue 7 Pages 949-953
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThis is to report a case of ectopic ACTH producing pulmonary carcinoid.The patient was a 35-year-old female.In June 1988, she developed the symptoms of Cushing syndrome.There was no improvement after subtotal resection of the anterior pituitary lobe.Both adrenal glands were then removed in June 1989. After improvement in the symptoms was observed, an abnormal shadow in the left lung field was found and it gradually increased.Left upper lobectomy with lymph node dissection was performed on a diagnosis of ACTH producing lung tumor in Dec.1991.Serum ACTH levels obtained from pulmonary drainage vein in operation and within the resected tumor were remarkably high.After the operation, serum ACTH level returned to normal and the patient has shown a good course free of cancer.View full abstractDownload PDF (4498K) -
Toshikazu Hirai, Mitsuhiro Kamiyoshihara, Osamu Kawashima, Keiichi End ...1995 Volume 35 Issue 7 Pages 955-959
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 75-year-old female was admitted because of a tumor shadow on chest X-ray films for further examination and treatment.Transbronchial lung biopsy specimen demonstrated signet ring tumor cells, indicating mucus-producing adenocarcinoma of the lung. Left lower lobectomy with hilar and mediastinal lymph node dissection was performed. Histologically, the tumor was mainly composed of signet ring cells with abundant extracellular mucin Production, and immunohistochemically the cells were positively stained with surfactant apoprotein.The histological diagnosis was signet ring cell carcinoma of the lung.Signet ring cell carcinomas are generally found in the stomach, large bowel, urinary bladder but rarely in the lung.A routine histological study showed no significant difference in the signet ring cells of the lung and other organs.Thus, it is necessary to investigate both clinicopathological and immunohistochemical findings for the accurate diagnosis of this type of lung cancer.View full abstractDownload PDF (8459K) -
1995 Volume 35 Issue 7 Pages 961-970
Published: December 20, 1995
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1412K)
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