The behavior of leukemic cell infiltration in the testis or ovary was examined on 99 autopsy cases of various leukemia, which were performed in the Department of Pathology, Tokyo Medical and Dental University, from 1964 to 1975. The incidence of leukemic cell infiltration was 48.5% in the testis and 58.1% in the ovary. The frequency of leukemic cell infiltration in the testis or ovary itself showed no significant increase in recent years, although median survival time became longer by a more aggressive combination chemotherapy. These findings show that the testis and ovary are essentially a preferred site of leukemic cell infiltration. Especially in acute monocytic leukemia, leukemic cell infiltration was revealed in all cases. In addition, short discussions were made on the role of sex hormones in the infiltration, proliferation, and persistence of leukemic cells of each type of leukemia in the testis or ovary.

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Species of flies, Calliphora vomitoria (Linné) and C. pattoni Aubertin, four for the first time in Thailand are reported, together with detailed illustrations of genitalia. These are known to be Palearctic species, which are commonly found in Europe or northern parts of Asia. These flies were found in Doi Inthanon, the highest mountain in Thailand, which belongs to the Oriental region.

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The present study was conducted, from the view point of the effects of ozone upon rat, to investigate the toxic effects of 5-hydroxytryptamine (5-HT), the changes in the activity of the lung and serum monoamine oxidase (MAO), which metabolizes 5-HT, and the changes in the 5-HT content of various organs. In the rats exposed previously to ozone, a number of animals died by the intraperitoneal administration of 5-HT, though the control rats without previous exposure to ozone didn’t receive any lethal damage by the administration of the same dose of 5-HT. The mortality of the rats exposed previously to ozone increased as the dose of 5-HT was increased and the susceptibility to 5-HT increased as the ozone concentration became higher, but it decreased as the interval between the end of the exposure and 5-HT administration became longer and the increased susceptibility was detectable for as long as 12 1/2 hours. In the rats exposed to ozone, the activity of the lung and serum MAO was significantly inhibited as compared with the control, and these changes in the activity generally paralleled each other with time. In these rats, the 5-HT content of the lung and spleen was significantly increased, that of the brain was significantly decreased but no significant change in the 5-HT content was noted in the liver and kidney.

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The goal of this study is to reveal (1) the rate of elongation of upper alveolar process after loss of antagonistic teeth, and (2) a change in residual ridge area after extraction of upper elongated teeth. The subjects used in this study were seven crab-eating monkeys, which were divided into two groups; 0U5L group (extracted on M3M2M1P2P1) and 5U5L group (extracted on M3M2M1P2P1 and two years later M3M2M1P2P1). Three monkeys were in each group. In order to observe the morphological changes, impressions were taken before the extraction and at fixed intervals of three weeks, six weeks, three months, six months, one year, two years, and three years (only in the 5U5L group) after the extraction. Casts were made immediately thereafter. Then the changes in the height and cross-sectional area of the alveolar process or the residual ridge were measured. The method was the same as that described in Part I. The results were as follows: 1) 0U5L group: In the first six week period after extraction of antagonistic teeth, the height of the upper alveolar process increased rapidly, and thereafter continued to increase over the two year period. Also the change in the cross sectional area displayed the same tendency as the growth in the height of the alveolar process. 2) 5U5L group: In the first three week period after extraction of the elongated teeth, height of the residual ridge decreased rapidly, and from then on, decreased gradually over the next three year period. However, even after the decrease in height over the three year period, the height of the residual ridge was still greater than the process before elongation of the teeth. The residual ridge area displayed the typical pattern of “rapid decrease followed by a gradual decrease”. However, even after three years the area was still slightly greater than that before the elongation. Thus it is clear that, unlike the decrease in height and area of the residual ridge following extraction of normally occluded teeth, the decrease in the elongated ridge appeared to be difficult.

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Based upon the autopsy findings, the incidence of distant metastasis was studied to seek the relativity between the method of treatment and the TNM system at the time of initial examination on 31 cases with squamous cell carcinoma in the maxilla-facial region. The results are summarized as follows: 1) The incidence of distant metastasis among all of these cases was 58 per cent. 2) There was no significant difference in the incidence between the groups with radiation therapy and chemotherapy. 3) There was no relativity with the TNM system. 4) In the group with radiation therapy, the incidence at the “sites of the movable mucosa” was significantly higher than that at the “sites of the non-movable mucosa.” 5) There was no relationship to the performance of radical neck dissection.

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Molars of mature Wistar rats were moved experimentally by orthodontic elastic for four days. Then, the aspects of ultrastructural changes of the osteoblasts and structure of the alveolar bone surface which appeared in experimental tooth movement were studied. The following results were obtained. 1) These osteoblasts are classified into three groups according to their position. 2) The most active response to the orthodontic force is exhibited by the second group of cells with the ability of rapid production of abundant acid polysaccharide; i) Abundant rough surfaced endoplasmic reticulum with markedly dilated cisternae. ii) Well developed Golgi apparatus and electron opaque granules with a limiting membrane are found in the cytoplasm. Large granules are frequently seen to be secreted out of the cell. iii) The mitochondria are of large size and round shape with well developed cristae. 3) The surface of the new alveolar bone is covered with a belt-shaped structure consisting of small dense spherical-shaped structures. 4) Osteoclasts are rarely seen, but the original function of the cells appears to be almost inactive.

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Virulent phages specific for Veillonella were isolated from washings of the oral cavity of 200 individuals. These phage strains were classified into two major groups, A (N1-11) and B (19-36), by their plaque morphology and serological characters. By the susceptibility to these phages, 21 strains of genus Veillonella were classified into four types (type I to IV). Type I corresponded to V. parvula, type II to V. reniformis, type III to V. alcalescens, and type IV to other strains of Veillonella. The growth curve of veillonellophage N2, N11, and N20 propagated on each of their host Veillonella revealed that they had a latent period of 55 min to maximum of 100 min, burst size ranging 40-120 and eclipse period of 20 to 100 min. Electron microscopy revealed that the group A phage had a hexagonal head of 670 Å diameter and wedge-shaped tail of 180 Å phage length and 90-180 Å width at the base. They were classified as type C according to Bradlaγs definition. Group B phages with a hexagonal head of 550 Å diameter, and a striated tail of 1300 Å length and 70 Å width were classified as type B of Bradley’s definition. More than 90% of group A phages and their host Veillonella were inactivation by ultraviolet (UV) irradiation, but group B phages and their host were comparatively resistant to UV irradiation. Photoreactivation of veillonellophages were not observed under aerobic and anaerobic condition.

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