The cytomegalic inclusion body disease or salivary gland virus infection is caused by the salivary gland virus which is species-specific, and characterized by formation of the cytomegalic inclusion bodies (CIB). The affected cells become dimensional enough to contain large intranuclear and sometimes granular intracytoplasmic inclusion bodies (Photo. 1). The CIB appear frequently in the parotid and submandibular glands, according to many studies which have been already reported. The purpose of this study is concerned with the portal of entry and the route of infection of salivary gland virus to the submandibular gland, and also with the relationship of cell infiltration and affected cells.

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The electrocardiographic pattern obtained by radioelectrocardiogram exhibits principally a similar pattern as obtained by the standard lead-system used everywhere. However, the authors have become aware of the existence of quite a different pattern in some cases of radioelectrocardiogram as compared with the ordinary electrocardiographic recording. In this report the pattern recognition in the radioelectrocardiograms was performed by the transformation of the observed patterns to the symbolic patterns, and a trial on the operation research employing the discriminant function in order to deal objectively with the data obtained from the symbolic pattern will be described in the present report.

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The function of cell membrane is considered to have an essential role in transport of metabolites across the cell membrane. The investigation of its function, however, was hampered by the difficulty of obtaining pure preparation of cell membrane. Firstly, Palade l) and Hogeboom et al 2) found “cell membrane” in the nuclear fraction isolated from liver homogenate. In 1960, Neville 3) succeeded in isolating the cell membrane fraction from rat liver, and identified morphologically with electron microscope. His isolation procedure consisted of homogenization with a Dounce homogenizer in 0.001 M NaHCO3 (pH 7.5) followed by sucrose-gradient centrifugation between d = 1.22 and 1.16 at 100,000 g for 75 minutes. Recently, Emmelot and Bos 4) modified the final centrifugation procedure of Neville 3) by separating the membrane fraction between the layers of d = 1.16 and d = 1.22 placed a third layer of sucrose solution of d = 1.20. The modified procedure enabled isolation of the membrane fraction practically free of mitochondria. The preparation was shown to contain no hexokinase, succinate cytochrome c reductase and cytochrome c oxidase activity, but weak activities of glucose-6-phosphatase NADH cytochrome c reductase, and a pronounced ATPase activity were demonstrated. The specific activity of ATPase in the cell membrane fraction was 6 times higher than that of the microsome. In this paper, a modified procedure is presented to attain higher purity of the cell memberane preparation from liver, kidney and testis of rat and rabbit and the results on distribution of ATPase and alkaline phosphtase in four fractions will be reported.

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Although the esophageal hiatal hernia was recognized by Morgagni 1) in 1769, only recently much attention has been paid to the situation and numerous works have been issued in Europe and America. In Japan, however, the incidence of the hiatal hernia was reported 2·3·4·5) to be considerably lower than that in Europe and America. We have now studied causes on the difference between the two and have known that a careful examination can find out the situation with the greater frequency. The following study was made in attempt to set up roentgen criteria for the diagnosis of hiatal hernia to determine the roentgen incidence of this disease in Japan and, to clarify the functional derangement secondary to the situation. In addition, an examination was taken on whether or not there were changes on telemetering electrocardiogram in the patients with hiatal hernia after eating and exercise.

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In 1961, we published a report on 608 patient s with cancer of the mouth treated at the Section of Oral Surgery in the Tokyo Medical and Dental University Hospital between 1930 and 1960 with a reference to the incidences of oral malignancies 1). In this paper, the same 81 patients with cancer of the tongue were reviewed again from a different point of view on their treatment and results adding 28 newly treated patients with cancer of the tongue, who called us for treatement until December 1963.

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