The organon vasculosum laminae terminalis has been studied by many investigators in various animals. Recently Weindl et al. ('67)1) studied electron microscopically the organ of the rabbit, particularly the vascular system of the organ. Although there are many investigations on the organ, its function remains obscure. Therefore, in the present study the author attempted to investigate this organ electron microscopically with special reference to the ependymal cells. The ependymal cells, unlike the ordinary ones, have neither cilia nor microvilli. Instead, two kinds of ependymal protrusions can be found, which is confirmed by making their three-dimensional reconstruct ions out of their serial electron micrographs. The first type is not a microvillus, but a fin like thin fold of the apical cytoplasm akin to the marginal fold of Fawcett ('63, '65, '66)2-4). This type of protrusion has not been reported previously in the ependymal cells. The second type is a protrusion of the kind that is irregular in shape and size, and in most cases, it shows "coated" and uncoated invaginations or vesicles. Moreover, in the apical cytoplasm are observed a large number of smooth-surfaced vesicles and some multivesicular bodies and also dense bodies. All these structures are considered to be closely related to absorption.

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Examinations were made on a total of 618 cases surgically operated for gastric cancer in the 1st Department of Surgery of this university, and the presence of ulcuscarcinoma was critically examined clinically and histopathologically, using the criteria adopted by the Japan Association of Gastric Cancer Research, and also those proposed by Murakami and Oota. Presence of ulcuscarcinoma was found in some of the cases but no conclusive evidence was obtained from the present study to accept or deny the suggestion that ulcer precedes carcinoma. Early diagnosis of ulcuscarcinoma, and resection in an early stage have been stressed.

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This experiment is directed to study the chronic radiation injury of nail. The ridging of nail plate in chronic radiation damage of nail may be caused by the combination of radiation injury to the nail matrix, hyponychium and nail lamellae. Fragility may be resulted from frequent interruption of mitosis in nail matrix. The thickenning of nail plate was not remarkably observed in this experiment. The thickenning of nail plate reported in man associated with chronic radiation damage to nail can be explained by slowing clown of forward movement of nail plate, incompleteness of successive cell differentiation and coarseness of nail plate. In other words, various changes of nail reported as a chronic radiation injury of nail in man2-4) seem to be ones in the fractionated irradiation in the experimental animal.

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Paramagnetic profile of hepatic subcellular particles was observed with electron spin resonance (ESR) spectroscopy. ESR signals of mitochondria and microsome revealed a special feature respectively, that is, the former consists of spectrum of non-heme-iron and the later of one of heme-iron (low spin type). These signals were responsible to various reagents, especially reductant and oxidant. Moreover, it was noted that the signal of mitochondria was degraded completely by urea treatment though the microsomal signal remained unchanged. This fact suggests that the non-heme-iron of mitochondria consists of iron protein. The absorption spectra of liver homogenate were identified being composed of the signals of mitochondria and microsome. Basing on these results, ESR spectra of rat hepatoma cells with different strains and life time were detected. A specific three-peaks signal at g=2.00 was observed in the most cells of hepatoma and its structure was discussed.

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Employing our apparatus of electrical dissection, the F vector loop was taken by Frank’s lead system in six cases of atrial flutter. In most cases the F loop was inscribed continuously as a vertically long loop, rotated counterclockwise in the left sagittal and the frontal plane. The left half of the loop was inscribed more slowly. Two cases showed an apparent point of origin. In one of them the main portion of the F loop was directed superiorly, anteriorly and to the right. In the other it was directed vertically inferiorly.

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A longitudinal investigation was carried out in the qualitative and quantitative changes of the mandible, especially the edentulous ridge, wearing the extension saddle type of removable partial denture. The materials were the patients who had attended the Department of Prosthetics, School of Dentistry, Tokyo Medical and Dental University, in Tokyo. They were complete dentition in upper jaw, but the lower molars and premolars were missing. On 68 patients during a limited period of time, the initial examination was performed. Forty-one patients appeared for re-examination after one year follow-up. At the initial and follow-up examinations, the standardized roentgenograms of mandible, the bite ability checking and other clinical registration were precisely performed. On these roentgenograms, the changes in mandibular height in edentulous parts of the alveolar were measured. And on these same films, the density of residual ridge was measured by the multiplier photometer. All these data were computed in statistical methods. The results of these investigations were as follows: 1. The reduction of residual ridge of free end saddle denture wearer who was in short term after extraction, was about 0.90 mm (in mean) at the first and second molar region for one year follow-up. But in the case, long term after extraction without denture, (disuse atrophy) the reduction was most remarkable, about 1.30 mm (in mean) on the same region. In the case of re-making denture, the amount of reduction was more smaller, 0.60 mm in the first and second molar, than other cases. 2. On the amount of reduction in residual ridge, the cobalt-chromium cast denture wearer was smaller than resin denture wearer. 3. In the case, long term after extraction without denture wearing (disuse atrophy), the extent of reconstruction in alveolar ridge against the denture wearing loads was signicantly poor than the case of short term after extracion. 4. The degree of increasing about abutment teeth mobility was concerned with the intensity of tooth-bearing loads of the denture. 5. The factors influencing on the amount of reduction and structural reconstruction against denture wearing, were the loading condition on residual ridge and the length of term after extraction without denture wearing.

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