THE BULLETIN OF TOKYO MEDICAL AND DENTAL UNIVERSITY

The aim of this study was to investigate the development of root surface caries in hamsters fed a high-sucrose diet over a 24-week period after inoculations of two types of cariogenic bacteria. Twenty-one-day old male golden hamsters (n= 103) were divided into 5 groups. Four groups were given diet 2000, and one group was given a stock diet CE 2. Of the groups given diet 2000, three groups were infected with Actinomyces viscosus ATCC 15987 and Streptocοccus mutans NTCC 10449 separately (AV and SM groups) or in combination (AVSM g1oup), and one group remained uninfected. A grid method was used to evaluate the plaque accumulation, alveolar bone loss, and root surface caries. After 12 weeks, root surface caries developed mainly on the first mandibular molars in the three infected groups. At 24 weeks, the prevalence of root surface caries was highest in the AV group, but root caries scores were not significantly different among the three infected groups. In the groups SM and AVSM, the molar crowns were extensively destroyed by caries, while in the AV group the crowns were almost intact. It was concluded that challenge with Actinomyces viscosus may be appropriate to stud y root surface caries in hamsters.

抄録全体を表示

抄録を表示する抄録を非表示にする

The aim of this investigation was to evaluate the effect of topical applications of various fluoride compounds on the development of root surface caries in hamsters. Male golden hamsters (n=115) were divided into 7 groups and were given a caries-promoting diet. Six groups were infected with Actinomyces viscosus ATCC 15987; and to 5 infected groups, distilled water (DW) and solutions containing 500 ppmF of acidulated-phosphate fluoride (APF), stannous fluoride (SnF2), copper fluoride (CuF2), and titanium tetrafluoride (TiF4) were applied topically to the first mandibular molars once daily, 7 days a week, over a 24-week period. A grid method was used to assess the periodontal changes and root surface caries on the first molars. Plaque accumulation was reduced most by SnF2; and alveolar bone loss was more reduced by SnF2 and CuF2. Root surface caries was significantly prevented in all fluoride groups when compared to an infected control group; and TiF4 was the most effective fluoride compound followed by SnF2, CuF2, and APF. Root caries scores of the TiF4 and SnF2 groups were significantly lower than those of the DW group. It was concluded that all fluoride compound s tested may prevent the development of root surface caries in hamsters.

抄録全体を表示

PDF形式でダウンロード (1332K)

J-STAGEへの登録はこちら（無料）