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Volume 109, Issue 1
Displaying 1-8 of 8 articles from this issue
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Shin-ichi Kanemaru2006 Volume 109 Issue 1 Pages 1-7
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSBecause of the limitations of the present medicine, regenerative medicine has greatly been hoped. Regenerative medicine is an exciting emerging branch of medicine in which cell and tissue based therapies are applied to the treatments of disease. This has been supported by the development of tissue engineering that was a complex of medicine and engineering. Tissue engineering applies the principles and methods of engineering, material science, and cell and molecular biology toward the development of viable substitutes which restore, maintain, or improve the function of human tissues.
According to the doctrine of tissue engineering, tissues and organs can be regenerated by manipulating three elements: cells, scaffolds and regulation factors. Understanding and manipulating the complex relationship among these elements, however, represents the great challenge for researches and doctors who engage in regenerative medicine.
On the other hand, clinical applications of it have not made progress yet except limited tissues and organs. Especially, few clinical studies have reported in the fields of otolaryngology, head and neck regions. In our research group, clinical applications in these fields based on the new concept of in situ tissue engineering have been started from 2002 after approval of the ethical committee. Tissues and/or organs for clinical applications at present are trachea, cricoid cartilage, mastoid air cells, and, peripheral nerves including facial nerve, recurrent laryngeal nerve, chorda tympani nerve and so on.
This article describes the researches and clinical studies at present and in the near future of regenerative medicine in the fields of otolaryngology, head and neck regions.View full abstractDownload PDF (1567K) -
[in Japanese], [in Japanese], [in Japanese]2006 Volume 109 Issue 1 Pages 8-10
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESS -
Clinical Meaning of Severity Grading of DysphagiaYuko Shiba2006 Volume 109 Issue 1 Pages 11-18
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSIt is more difficult to adequately manage dsyphagia patients at home than in the hospital.
Based on the author's experience with home visits, grading the severity of dysphagia is advocated as helpful in reducing the difficulty. Both the clinical meaning and usefulness of severity grading are discussed.
A diagnostic procedure designed by the author and ENT colleagues was applied to patients complaining of dysphagia at home. The procedure consists of three components, i. e., a questionnaire chart, endoscopic survey of the throat while swallowing and an assessment of the patient's general condition.
Analysis of 24 cases revealed that the severity of dysphagia could be classified into four degrees, and that the the severity was helpful for determing the protocol of subsequent treatment.
The part of the management of dysphagia at home in which the ENT physician can participate has been clarified.View full abstractDownload PDF (450K) -
Sayaka Suzuki, Masato Mochiki, Kazunari Nakao, Takashi Sakamoto, Mizuo ...2006 Volume 109 Issue 1 Pages 19-23
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSSingle-stage reconstruction of the pharyngoesophagus with a free jejunal graft is considered standard surgical treatment for hypopharyngeal cancer.
We reviewed postoperative cervical CTs in 72 of 136 consecutive patients (1982-2002) undergoing this therapy in our department. Of these, 29 (40%) showed mesenteric lymph node swelling (>10mm) in grafts. Most swelling is considered reactive, but 1 patient showed pathological metastasis in fine-needle aspiration cytology (FNA). When metastasis is clinically suspected in imaging study and other examinations, FNA should be done carefully with guided ultrasound echo-imaging, to avoid damaging vascular grafts and necrosis of the jejunal graft.View full abstractDownload PDF (2721K) -
Takeshi Yagi, Ken Hayashi, Hisayoshi Shikii, Yuko Miyamoto, Makoto Oda ...2006 Volume 109 Issue 1 Pages 24-29
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSPurpose: We studied the effect of volume reduction surgery by a radiofrequency (ENTec coblator TM) for enlarged adenoid causing recurrent otitis media with effusion.
Materials and Methods: The effect of volume reduction surgery by radiofrequency for enlarged adenoid was studied in 50 children with enlarged adenoid causing recurrent otitis media with effusion from June 2002 to September 2004, while a group of 50 children with tympanostomy-tube placement alone from April 2001 to September 2004, was used as the control group. Volume reduction surgery by radiofrequency system for enlarged adenoid was done with tympanostomy-tube placement under general anesthesia by laryngeal mask. We compared two groups in following 5 different aspects: (1) tympanostomy-tube replacement, (2) remyringotomy, (3) total visits to our clinic after surgery, (4) total days with antibiotics, (5) absence of effusion and normal middle ear function as seen on the tympanogram after tympanostomy-tubes loss. We evaluated the reduction of enlarged adenoid by using the pre-and postoperative obstructive rate of the choana through the nasopharyngoscope.
Results: The volume of enlarged adenoid was reduced an average of 52.2% by radiofrequency. The pharyngeal opening of the eustachian tube and the choana could be opened widely. No severe intra-or postoperative complications occurred. Compared to the control group treated with tympanostomy tubes alone, postoperative tympanostomy-tube replacement, postoperative remyringotomy, total postoperative visits to our clinic, total postoperative days with antibiotics, and tympanogram types C2 and B after tympanostomy-tubes loss decreased notably in cases with volume reduction surgery by radiofrequency for enlarged adenoid and tympanostomy-tube placement.
Conclusion: Volume reduction surgery by radiofrequency for enlarged adenoid is considered very safe, effective one-day surgery technique for recurrent otitis media with effusion.View full abstractDownload PDF (982K) -
Rie Oda, Tsuyoshi Takemoto, Motoharu Kawai, Hiroshi Yamashita2006 Volume 109 Issue 1 Pages 30-35
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSSpinocerebellar degeneration (SCD) exhibits a variety of spinal and cerebullar symptoms and progress. The recent advent of molecular genetics has revealed triplet repeat mutation in the gene of SCD patients. Due to the underlying genetic defects, hereditary SCD is referred to as different spinocerebellar ataxia (SCA) genotypes.
We conducted vestibular functional tests in 33 SCD patients, including 3 with SCA3 and 2 with SCA6. We compared the degree of lower extremity ataxia with the degree of oculomotor disorder by using eye tracking tests (ETT) and optokinetic pattern tests (OKP). Both SCA3 and SCA6 show high ETT score and low mean slowest phase velocity in OKP. This means that SCA3 and SCA6 tend to have oculomotor disorder precedes extremity ataxia.
Oculomotor examination should thus prove to be a useful, senstive indicator in screening SCD patients from early disease onset, and in evaluating the disease progression and the effectiveness of treatment.View full abstractDownload PDF (495K) -
[in Japanese]2006 Volume 109 Issue 1 Pages 64-67
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSDownload PDF (217K) -
[in Japanese]2006 Volume 109 Issue 1 Pages 68-69
Published: January 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSDownload PDF (114K)
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