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Volume 91, Issue 12
Displaying 1-14 of 14 articles from this issue
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AKIRA YAGI, HIROOMI TAKAHASHI, KAZUO YAO, HAJIME SANO, KENTARO NITTA1988 Volume 91 Issue 12 Pages 1987-1995
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSCarotid body tumor is a rare neoplasm, occasionally familial in occurence, is difficult to establish its malignancy histopathologically. In this paper, we report two cases seen in the same family. As far as our survey concerned present report on the familial incidence is the second in Japan.
Case 1: I. K., 13 years old girl.
She visited a hospital with complaints of the neck mass and low grade fever in Oct. 1985. Open biopsy of the neck mass was performed and the histopathological diagnosis was chemodectoma originated from the carotid body. She was referred to the ENT department of Kitasato University Hospital in Jan. 1986. Our initial impression was that the tumor was so large that in order to remove the tumor completely, it was neccessary to make a by-pass of the carotid artery, and the aurgery was deferred until her grow-up completed.
Operation was done in May 1987, because the tumor began to grow rapidly. During operation, the electro-encephalogram was monitored and the by-pass of the carotid artery by using the autograft of the jugular vein was performed. The removed tumor size was 70×50×35mm and histopathological study revealed benign type of carotid body tumor.
Case 2: I. T., 15 years old boy (the elder brother of the case 1)
At his sister's visit to the hospital, he happened to find out a neck mass in the left side of his neck.
The operation was done under general anetshesia with controlled hypothermia. Electroencephalogram was also monitored. The removed tumor was 40×35×25mm. Histopathological find was similar to his sister's case.
No regional cervical lymphnode metastasis was seen in both cases. Neither autosomal analysis nor HLA typing showed particular abnormal result. Since it has been reported that even the histopathologically benign carotid body tumor show late metastasis in recurrence, it is firmly suggested that follow-up study is important especially for young patient with familial incidence.View full abstractDownload PDF (3012K) -
TOSHIO YAMASHITA, YOSHIROU HORI, TOSHIYA INOUE, TADAMI KUMAZAWA, TSUTO ...1988 Volume 91 Issue 12 Pages 1996-2002
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSTwelve patients with postoperative maxillary cysts were examined with magnetic resonance imaging (MRI), and the results were compared with the results from conventional tomography and CT.
The exact location of these cysts could not be determined clearly via conventional tomography and CT, however, MRI showed the entire image of the cysts, even in the case of a small hidden cyst. With MRI multidirectional imaging, the extension of the cysts were easily identified without any image artifacts due to artificial teeth and MRI was valuable in deciding the surgical approaches. As well, in the case of these cysts, long spin echo (SE) showed a higher signal intensity than did short SE. Therefore, these cysts could be differentiated from any neoplastic mass which did not show a high signal intensity in long SE.
MRI was superior to conventional tomography and CT in diagnosing postoperative maxillary cysts and will be widely used in the future.View full abstractDownload PDF (2168K) -
HIROKO ODAIRA, TOMONORI TAKASAKA, TAKASHI SAWAI1988 Volume 91 Issue 12 Pages 2003-2010
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSOne ml of tap water (hypotonic solution) was poured into the nasal cavities of 40 tracheostomized guinea pigs. After the time interval ranging from 0 to 8 hours, 2ml of hoarseradish peroxidase saline solution (HRP Sigma typeVI: 3mg per ml in saline) was poured into the nasal cavity and septal mucosa was removed at five minutes after the HRP exposure. The mucous membranes were fixed with 2.5% glutalaldehyde in 0.1M phosphate buffer and were reacted for localization of peroxidase activity by the method of Graham and Karnovsky. After being postfixed with 2% OsO4 in 0.1M phosphate buffer, the blocks were dehydrated through graded ethanol. After embedding into epoxy resin, the 1μm thick sections and 80nm ultrathin sections were made and observed under a light microscope and an electron microscope (HITACHI H-600) with the accelerating voltage of 50KV.
The following results were obtained.
1) Immediately after hypotonic water exposure, the permeability of nasal epitherium became more accelerated.
2) HRP precipitates were present in the intercellular space and also in the cytoplasm of some goblet and cilliated cells.
3) It was also confirmed that HRP could enter the intercellular space through the tight junction.
4) The nasal mucosa remained permeable at least for 6 hours after the tap water exposure and its permeability gradually returned to normal thereafter.
Based upon the present experiments, it was concluded that hypotonic water exposure of the nasal cavity could change epitherial permeability although morphological changes of the junctional complexes were not obvious.View full abstractDownload PDF (2618K) -
YOSHIHISA KON1988 Volume 91 Issue 12 Pages 2011-2023
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThirty-four normal hearing subjects (23 males and 11 females) with the ages from 19 to 43, were submitted to impedance audiometry with Teledyne TA-2C acoustic impedance meter.
Stapedial reflex thresholds (SRT) were evaluated by the change in impedance elicited by the 1000Hz tone applied either contralateral or ipsilateral ear. The results were summerized as follows.
1) With a conventional method of recording stapedial reflexes, the mean values of SRT for contra and ipsilateral stimuli were 97.0dBSPL and 87.7dBSPL respectively, though the data showed 25dB-wide variation in both cases.
2) Both variations of SRT due to the contractions of facial muscles, the increased pressure of ear canal, and the test-retest periods were significantly smaller than the variation observed among the normal hearing subjects.
3) The SRTs showed no significant correlations with sex, age, hearing threhold level, uncomfortable loudness level, static compliance and ear canal volume of the subjects.
4) The mean value of SRT for contralateral stimuli was always higher than that for ipsilateral ones by 9.3dB when compared separately with conventional recording procedure, but only 2.9dB when compared simultaneous recording procedure, the difference being significant (P<0.05).View full abstractDownload PDF (868K) -
EIJI YUMOTO, TADAHIKO SAIKI, KAZUNORI OKAMOTO1988 Volume 91 Issue 12 Pages 2024-2029
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe authors applied nasal endoscopy for the surgical treatment of chronic paranasal sinusitis. The operative procedures included removal of diseased mucosa from the anterior ethmoid-middle meatus complex, and widening of the natural ostia of the frontal and maxillary sinuses, and occasionally of the sphenoidal sinus. A total of forty-one operations were performed on 26 patients in the period from August 1986 to January 1988. We evaluated the subjective symptoms and rhinoscopic findings of eight patients (including 13 diseased sides) six months after surgery. The condition of all patients had improved. Postoprative care was essential because polyps and pathologic granulation often narrowed the anterior ethmoid-middle meatus complex. Nasal endoscopy provided an excellent view of the complicated cavity of the ethmoid sinus. However, one disadvantage of endoscopic surgery is that the endoscopes are not of binocular vision, and do not provide sense of depth of surgical field. Thus, even when operating on deep structures of the ethmoid sinus, it is difficult to ascertain the true depth of the operative site.View full abstractDownload PDF (1416K) -
HIDETO KOBAYASHI, KANEMASA MIZUKOSHI, YUKIO WATANABE, NAOKI OHASHI1988 Volume 91 Issue 12 Pages 2030-2038
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIn 112 patients with focal lesions of the central nervous system, the visual-vestibulo-ocular reflex (VVOR) and the vestibulo-ocular reflex (VOR) gains were examined and compared with other otoneurological findings.
The various types of abnormal VOR and VVOR gains were observed in 112 patients with well-defined central nervous system disorders. Decreased VOR and VVOR gains were frequently seen in patients with the brain stem lesions and in those with combined cerebellar and brain stem lesions.
Results of VOR and VVOR tests were as follows.
1. These tests are useful not only as screening tests but also for the topodiagnostic evaluation of central nervous system lesions.
2. Because the changes of VOR and VVOR gains parallel with the clinical symptoms, they are useful and appropriate systems for following the progress of central nervous system disorders as is the case in peripheral vestibular disorders.
3. It is suggested that VVOR is consisted of the algebraic summation of VOR and OKN, and the interaction of VOR and OKN was regulated mainly by the brain stem function.
4. The abnomal VOR and VVOR gains were not always associated with abnormal visual fixation of caloric nystagmus, so there might have been some different mechanism between VVOR and the visual fixation of caloric nystagmus from the standpoint of clinical examinations.
5. The examination of VOR and VVOR together with other otoneurological tests, leads us the better understanding of the pathology of the brain stem and cerebellum.View full abstractDownload PDF (619K) -
TOMOHIKO HASEGAWA1988 Volume 91 Issue 12 Pages 2039-2050
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIn monkeys as well as non-primates, the nucleus of the optic tract (NOT) is considered to be the first relay station in the pathway of horizontal optokinetic nystagmus (OKN). The slow phase velocity of the OKN induced by constant velocity stimulation can be divided into two components: an initial rapid rise and a subsequent slow rise to steady state level. To determine the role of the NOT on OKN and optokinetic after-nystagmus (OKAN), pretectal lesions were made by scalpel or by injecting kainic acid in 8 Fuscata monkeys. In three monkeys with complete destruction of the NOT, no slow rise of OKN nor OKAN were produced towards the lesion side. In three monkeys whose NOTs were partially damaged, the slow rise and OKAN were partially reduced toward the lesion side, in proportion to the expansion of NOT-lesion. In 2 of these 6 monkeys whose lesions were placed by scalpel and covered the medial pretectum, the rapid rise was also reduced. In one of remaining two monkeys whose medial pretectum was selectively destroyed by scalpel, the rapid rise was reduced towards the lesion side, leaving the slow rise and OKAN intact. In one monkey whose medial pretectum was selectively deamaged by kainate, the OKN and OKAN were intact and other visually induced eye movements were also normal. These findings indicate that charge characteristics of the velocity storage mechanism is selectively damaged by NOT lesions, in that the slow rise of OKN and OKAN are abolished, while vestibular nystagmus is unaffected. The results also indicate that the rapid rise may be mediated by the axons which run through the medial pretectum.View full abstractDownload PDF (915K) -
HIROAKI ICHIJO1988 Volume 91 Issue 12 Pages 2051-2061
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThis study was performed to compare the clinical data from the two different kind of rotation tests: Trapezoid Rotation (TR) test (±2, 4, 6, 8, 10°/sec2, 10") and Sinusoidal Harmonic Acceleration (SHA) test (0.01, 0.02, 0.04, 0.08, 0.16Hz).
Twenty five normal subjects and 110 patients with peripheral vestibular disorders were examined by these two rotation methods with Contraves' computerized rotary chair on the same day. The following results were obtained:
1) The finding of vestibular asymmetry detected by the two rotation methods agreed in 75.9 % of all patients, while the remainder showed the different results. The abnormality detected by TR test was found in 57.2% of the patients, which was higher than that of SHA test (45.5%).
2) In normal subjects, the maximum slow-phase velocity of per-rotatory nystagmus by TR test was greater than that of SHA test using the approximate value of the angular acceleration. The cause of difference between the results of these two rotation methods was thought to be that the maximum slow-phase eye velocity of per-rotatory nystagmus was more clearly induced by TR test than by SHA test.
3) As to the finding of abnormal VOR-Gain, the results of TR test coincided with that of SHA test in 100% of cases with bilateral vestibular disorders. In cases with unilateral vestibular disorder, however, the rate of the abnormality detected by SHA test was higher than that of TR test.
Namely, the abnormality of VOR-Gain in nystagmus directed to the affected side was found in 22.6% by SHA test, and in 11.3% by TR test.View full abstractDownload PDF (1419K) -
NAOHIRO TAKEDA, YOSHIHIKO NISHIMURA, TAKEO KUMOI1988 Volume 91 Issue 12 Pages 2062-2068
Published: December 20, 1988
Released on J-STAGE: December 15, 2008
JOURNAL FREE ACCESSThe post traumatic enophthalmos caused by the blow out and malar bone fractures is subject to an early surgical intervention. In the early treatment, the post traumatic enophthalmos can be corrected with repositioning the orbital soft tissue and repairing the orbital walls. Cases whose post traumatic enophthalmos had been poorly corrected or cases with long-standing enophthalmos will necessitate to decrease the orbital volume itself, because the orbital content is decreased. To decrease the orbital volume, graft implanting such as an allo-plastic material or an autogenous iliac bone plate to the lateral part of the orbit in combination with orbital floor plasty allow appropriate improvement of the post traumatic enophthalmos and also provide safe method of choice with less surgical sequelae.View full abstractDownload PDF (1935K) -
EFFECT OF ADOPTIVE IMMUNOTHERAPY BY INTRA-ARTERIAL INFUSION OF KILLER CELLS STIMULATED BY AUTOLOGOUS TUMOR IN PATIENTS WITH MAXILLARY CARCINOMAMASAO EURA, TSUTOMU IKAWA, TAKERU ISHIKAWA, TADAHIRO FUKIAGE, MASATO F ...1988 Volume 91 Issue 12 Pages 2069-2078
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSAutologous tumor and lymphokine activated killer (ATLAK) was induced by mixed lymphocyte and autologous tumor cell culture and further activated with recombinant interleukin 2 (rIL2). Peripheral blood lymphocytes were drawn from 2 patients with maxillary squamous cell carcinoma by means of leukapheresis, and autologous tumor cells were isolated from cancer tissue obtained from the patients by maxillary sinus open-biopsy. ATLAK was infused into maxillary artery through the superficial temporal artery 4 to 5 times in a week for 2 to 4 weeks. Lymphokine activated killer (LAK) was supplemented after 4 to 5 times infusion of ATLAK, when cell number of autologous tumor stored, as a stimulator, was not enough to continue the induction of ATLAK. The results indicated that the therapy was significantly effective on the reduction of tumor mass. Both cases received maxillectomy after the infusion therapy, and the tissues incised were histopathologically investigated. Strong anti-tumor effect was proved by the marked findings, such as tumor degeneration, and lymphocytes and scavenger macrophages infiltration around them. Side effects were minor, such as slight fever and temporary pain of the cheak at the time of cell infusion.View full abstractDownload PDF (3338K) -
INDUCTION OF KILLER CELLS BY STIMULATION WITH ALLOGENEIC TUMOR CELLTSUTOMU IKAWA, TAKERU ISHIKAWA, MASAO EURA1988 Volume 91 Issue 12 Pages 2079-2081
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSMaxillary squamous cell carcinoma cell line (KOIMC-001), which was established in our laboratory, was used as stimulator of lymphocytes from patients with head and neck cancer to induce autologous tumor killing lymphoid cells. Killer cells induced by stimulation with KOIMC011 and further activated with recombinant interleukin 2 (rIL2) were represented here as allogeneic tumor and lymphokine activated killer (AlloTLAK). The killing activity and specificity to the autologus tumor were investigated by direct tumor killing assay and cold target inhibition test, comparing with those of killer cells induced by stimulation with autologous tumor and further activated with rIL2 (ATLAK) or rIL2 only (LAK). The killer activity of AlloTLAK was significantly induced, but lower than that of the ATLAK, higher than that of LAK. Autologous tumor specificity of AlloTLAK was also lower than that of ATLAK. Although induction and effector mechanisms of AlloTLAK remains obscure, it has been, at least, clarified that AlloTLAK lyses the autologous tumor but not autologous PHA blast. This phenomenon may be clinically important to resolve the limitation of ATLAK therapy for head and neck cancer.View full abstractDownload PDF (216K) -
EFFECT OF ADOPTIVE IMMUNOTHERAPY BY INTRA-ARTERIAL INFUSION OF KILLER CELLS STIMULATED BY ALLOGENEIC TUMOR IN PATIENTS WITH LINGUAL AND MAXILLARY CARCINOMATAKERU ISHIKAWA, TSUTOMU IKAWA, MASAO EURA, TADAHIRO FUKIAGE, SEIICHI ...1988 Volume 91 Issue 12 Pages 2082-2088
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSPeripheral blood lymphocytes from patients with lingual or maxillary cancer (well differentiated squamous cell carcinoma) were mixed allogeneic tumor cell line originated maxillary squamous cell carcinoma, and further activated with recombinant interleukin 2 (rIL2) to induce autologous tumor killing lymphoid cells (AlloTLAK). AlloTLAK was infused back to the patients directly into lingual or maxillar artery. Results indicated a significant primary effect on reduction of tumor mass in the both cases. Tumor size of lingual cancer was markedly reduced from 55mm to 18mm diameter by 4 times infusions of AlloTLAK. Tumor of maxillary cancer staged as T3 was completely disappeared by 10 times infusions of AlloTLAK, and at least the surgical operation became unneccessary in this case. The case with lingual cancer received surgical operation to remove 1/3 of the tongue with radical neck dissection, and the tissues were histologically examined. Histological findings proved marked anti tumor effect of AlloTLAK demonstrating strong degeneration of the tumor cells with infiltration of lymphocytes and scavenger macrophages. Side effects were minor, such as slight fever and blood eosinophilia, which may be due to the rIL2 functionView full abstractDownload PDF (2621K) -
SUSUMU MUKAI1988 Volume 91 Issue 12 Pages 2089-2095
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSVocal cord movements during sniff were observed with a laryngo-fiberscope in 71 normal and 9 anosmic subjects. The vocal cords adducted during sniff in both groups. The mean duration of vocal cord movements during sniff was 0.52sec. in normal subjects, while 0.56sec. in anosmic subjects. When 0.05% naphazoline nitrate solution was sprayed suddenly into the opposite unanesthetized nasal cavity in 5 normal and 6 anosmic subjects, a glottic closure was observed in 2 out of the 5 normal subjects, and in 2 out of the 6 anosmic subjects. Laryngeal adductory movements during sniff were also observed in two subjects whose larynx, pharynx and both nasal cavities were anesthetized, and in one subject who was not anesthetized at all. No laryngeal adduction was observed when five normal subjects pinched their noses and attempted to inhale through the mouth as in sniffing. In addition to the experiments reported above, the nasal airflow rate was measured in 26 normal subjects during ordinary inspiration and sniff. Mean nasal flow rate at 1 cmH2O nasal resistance was 178ml/sec in inspiration and 143ml/sec in sniff. The ratio between sniff/inspiration was 0.81. The author concluded that the larynx has a significant relationship with olfaction.View full abstractDownload PDF (1623K) -
TAKAO IKARASHI1988 Volume 91 Issue 12 Pages 2096-2109
Published: December 20, 1988
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSTo study the postnatal development of the cerebellar afferent neurons in the inferior olivary nuclear complex as the climbing fiber and in the pontine nuclei as the mossy fiber, HRP (Sigma type VI) has been injected into cerebellar vermis and hemispheres of 1, 3, 5, 7, 14, 21 and 28 day after birth, and observed the HRP-labeled neurons in the inferior olivary nuclear complex and pontine nuclei with the light microscope.
In the inferior olivary nuclear complex of the hemispheric injection the HRP-labeled neurons were mainly distributed throughout the principal nucleus and the rostral part of the medial accessory nucleus contralatelly, and in that of the injection into vermis the HRP-labeled neurons in the caudal part of the medial accessory nucleus bilaterally. Also, in the pontine nuclei of the hemispheric injection the HRP-labeled neurons were distributed thoughout almost the pontine nuclei contralaterally and partially the dorsal part of pontine nuclei ipsilaterally, and in them of the injection into vermis the HRP-labeled neurons the dorsal part of pontine nuclei bilaterally. These distributions in both nuclei are almost remained from 1 to 28 day after birth.
Subsequently, we have studied the structure of the HRP-labeled neurons in the both nuclei at 1, 7 and 28 day after birth. In the pontine nuclei, at 1 day the HRP-labeled neurons were immature and the structure of their dendrites showed the profile of cytoplasmic processes, but at 7 and 28 day their differentiations were more advanced. While in the inferior nuclear complex, HRP-labeled neurons were already mature at 1 day after birth.
From these findings it is concluded that the projection fibers derived from the inferior olivary nuclear complex and the pontine nuclei have already invaded into the cerebellum and the distribution of their cerebellar afferent neurons in both nuclei seems to be determined at 1 day after birth although the neurons are immature.View full abstractDownload PDF (4129K)
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