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Volume 92, Issue 12
Displaying 1-15 of 15 articles from this issue
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MIKIKAZU YAMAGIWA, RYO AMESARA, YASUO SAKAKURA1989 Volume 92 Issue 12 Pages 2017-2022
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIn order to elucidate the relationship between a choking lump sensation in the throat and psychosomatic status, the authors subjected 339 in-patients above 17 years of age with various kind:of otorhinolaryngologic diseases and evaluated their psychosomatic conditions by means of twc questionnaires : Cornell Medical Index Questionnaire (CMI) and Maudsley Personality Inventory (MPI).
According to the answer to one of the CMI questions " Do you often feel a choking lump in your throat?", the patients were devided into two groups : " Yes " group and " No " one. " Yes " group comprised 51 males (56. 1-15.6 years old of mean-SD age) and 34 females (57.9-13.9 years old)and " No " group 170 males (57. 7-14.3 years old) and 84 females (47.8-15.8 years old). The data were analysed for comparison between the two groups and the following results were obtained.
Patients with benign and malignant oral, pharyngeal and laryngeal diseases were included in the " Yes " group with a significantly higher rate when compared to the patients with benign and malignant ear or nasal diseases. Patients in " Yes " group made significantly more complaints and judged to be significantly more neurotic and autonomic nerve dysfunctioning than those in " No "group.
Therefore, diseases in the pharyngolaryngeal region more likely produce abnormal sensation in the throat as well as many other symptoms relating to the autonomic nerve function.View full abstractDownload PDF (398K) -
MIKIKAZU YAMAGIWA, MASAHIKO KUBO, YASUO SAKAKURA1989 Volume 92 Issue 12 Pages 2023-2028
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIf the abnormal sensation, such as a lump or choking, in the throat was mainly caused by inflammatory changes in the palatine tonsils or their surrounding tissues and conveyed via vagal nerve branches distributing there, the sensation might be reduced by topically injected Impletol (Procaine and caffeine in saline solution), i.e. Impletol test for focal tonsillitis.
One hundred patients with abnormal sensation in the throat were injected Impletol (Impletol group), 50 patients were injected saline solution alone (Saline group) and 50 patients had injection needle simply inserted into the peritonsillar tissues (Needle group). The Impletol group showed the best result and was followed by Saline group and then Needle group. Namely, the degree of sensation reduced by 80% or more in 38% of the Impletol group and by 50% or more in 62% of them. Those rates were 26% and 60% for Saline group and 28% and 52% for Needle group, respectively.
Though the results were indicative of the effectiveness of the Impletol injection for the abnormal sensation in the throat, the difference among these three groups was not statistically significant.View full abstractDownload PDF (1004K) -
TAKASHI FUKAYA, YASUYA NOMURA1989 Volume 92 Issue 12 Pages 2029-2033
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSAudio-vestibular functions and its laterality were evaluated preoperatively on the affected side and the non-affected side of 57 patients operated upon to relieve hemifacial spasm (HFS). One patient had hearing impairment and tinnitus on the affected side and showed abrupt high tone sensorineural loss, directional preponderance and ABR abnormalities. On another patient, the latencies for wave III and V from the affected ear were prolonged, while there was no audio-vestibular symptoms.
However, there was no significant difference in audio-vestibular symptoms, ABR findings, pure tone thresholds and caloric results between the affected ears and the non-affected ears of the remainder. We believe that HFS and the microvascular compression of the eighth cranial nerve are two different diseases.View full abstractDownload PDF (1457K) -
YAYOI MIZUNO, YOSHIHARU HIROTA, TOSHITAKA IINUMA1989 Volume 92 Issue 12 Pages 2034-2038
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThe image of the maxillary sinus obtained by Waters' view contains such superimposed structures as lateral extensions of the sphenoidal sinus and posterior ethmoidal cells. Planimetric evaluations were done for the maxillary sinus itself and the two superimposed sinuses. The medial portion of maxillary sinus is occupied by these two sinuses and the areas covered by these amount to one third of the maxillary sinus' area.
To properly interpret the radiolucency of the maxillary sinus, the areas covered by these two sinuses and the areas corresponding to the zygomatic recess should be avoided.
The proper radiolucency of the maxillary sinus should be evaluated at the central portion, namely at and around the point where the vertical line passing the inferior orbital canal and the horizontal line passing the foramen rotundum meet each other.View full abstractDownload PDF (1127K) -
MAKOTO ASHIHARA, TADAO NISHIMURA, MASAO SAKAI, IKUKO NAGATSU1989 Volume 92 Issue 12 Pages 2039-2046
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSCarnosine ( -alanyl-L-histidine), a putative neurotransmitter, was identified immunohisto-chemically in the primary olfactory neuron, using newly developed anti-carnosine antiserum.
Similar results were obtained in the rat and suncus. Carnosine-like immunoreactivity was observed in the olfactory cells and its apical dendrites of the olfactory epithelium.
The olfactory nerve and glomerular layer of the olfactory bulb showed positive reaction. At electron microscopic level, carnosine-immunoreactive endoproducts widely spread out in the cytopiasm of olfactory nerve cells and also on microtubules of olfactory cilia.
In the glomerular layer, reaction products were found diffusely in many axon terminals.These terminals had small spherical vesicles and often made asymmetric synaptic contacts to the second neuron. Unilateral closure of the olfactory naris resulted lower immunoreactivity of tyrosine hydroxylase in periglomerular cells, which are dopaminergic interneurons and are thought to regulate neurotransmission of olfactory input. In contrast no remarkable changes were seen on carnosine immunoreactivity in olfactory bulb.
The present results suggest that carnosine may play some important roles in the olfactory mucosa. The functional role of carnosine remarks to be further examined.View full abstractDownload PDF (3346K) -
KOJI IWASAKI, ISAMU ONO, SATOSHI EBIHARA1989 Volume 92 Issue 12 Pages 2047-2054
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSA total of 27 cases of salivary gland adenocarcinomas were studied from clinicopathological view point. Adenocarcinomas of the salivary gland were microscopically subclassified into 3 groups according to Luna's classification : Salivary duct carcinomas histologically resembled the ductal carcinoma of the breast, displayed nuclear atypia and had poorer prognosis than the other subclasses of salivary gland adenocarcinomas. Terminal duct carcinomas lacked in nuclear atypia and displayed a variety of growth patterns, including papillary, cribriform, tubular, and solid. Some terminal duct carcinomas showed prominent mucin-production. Epithelial-myoepithelial carcinomas had clear cytoplasms and exuberant glycogen.
In addition to the clinicopathological study, nuclear areas of the tumor cells were measured in each of the 27 salivary gland adenocarcinomas, and mean nuclear area (MMA) and standard deviation (SD) were calculated. The group with more than 50 um2 of MNA had poorer prognosis than the group with 50 um2 or less of MNA, and the group with more than 13 um2 of SD had poorer prognosis than the group with 13 um' or less of SD.
Finally, immunohistochemical study was performed against various markers including keratin, epithelial membrane antigen, lactoferrin, S-100 protein, CEA, etc., using the Avidin-biotin-peroxe idase complex method. Lactoferrin was present in most of the salivary duct carcinomas, on the other hand, S-100 protein was detected in all of the five cases of the terminal duct carcinoma investigated. But immunohistochemical study is not especially useful in distinguishing subclasses of salivary gland adenocarcinomas or investigating the origin of tumor cells.View full abstractDownload PDF (2689K) -
YASUSHI FURUTA, YUKIO INUYAMA, KAZUO NAGASHIMA1989 Volume 92 Issue 12 Pages 2055-2063
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSIt is being reported that human papillomavirus (HPV) has been implicated in the pathogenesis of various neoplastic lesions of the genital organs. To investigate the etiological role of HPV and its types in nasolaryngeal papillomas, we retrospectively analyzed HPV genomes by nucleic acid hybridization methods ; for detecting DNA and mRNA, we employed the recently developed non-radioactive (digoxigenin labeled) DNA probes and compared the results by radioisotope methods.
In total, 43 cases of papillomatous lesions were examined. They were verruca vulgaris of the nasal vestibule (Nr=2), nasal inverted papilloma (IP, Nr=26), and laryngeal papilloma (Nr=15).HPV types examined were type 2, 6, 11, 16 and 18.
Two cases of verruca vulgaris were shown to contain HPV-2 DNA and its mRNA by in situ hybridization. HPV-11 DNA was detected in 3 cases (12%) of nasal inverted papilloma whereas HPV-16 was detected in 1 case (4%) ; the latter case was associated with squamous cell carcinoma.These results suggest that HPV may be implicated in the development of IP, and HPV-16 may play an important role in the malignant transformation of IP. In the cases of multiple laryngeal papilloma (Nr=8, one juvenile type and 7 adult type), either HPV-6 or HPV-11 was detected at the high rate (6/8, 75%). The presence of the HPV genomes provides strong evidence for the HPV etiology of these laryngeal papillomas. Whereas in the cases of adult single laryngeal papilloma (Nr=7), HPV was not detected.
Technically, the sensitivity of digoxigenin (DIG) labeled DNA probe was almost same as 35S labeled probe by dot blot hybridization, thus we applied DIG labeled probe to Southern blot hybridization with low background. By in situ hybridization using digoxigenin labeled probes, the rates of HPV detection were almost equal to those by 35S labeled probes. But non-specific reaction was occasionally found in DIG-labeled probes. However, the pretreatment of DNase orRNase markedly diminished non-specific binding to the nucleic acids. Thus, DIG-label was shown to be excellent substitutional method for radioisotope.View full abstractDownload PDF (2523K) -
THE QUANTITATIVE STUDY BY IMAGE ANALYZERHIDEAKI MATSUYAMA, NOBORU YAMANAKA1989 Volume 92 Issue 12 Pages 2064-2078
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDistribution of various immunocompetent cells, i.e., IgG-, IgM-, IgA-, IgD-, IgE-, CD4-, and CD8-positive cells in palatine tonsils (tonsils) and pharyngeal tonsils (adenoids) of same patients were investigated immunohistologically by using monoclonal antibodies.
The proportion of Ig-positive cells and T cell subsets in both tonsils were quantitatively studied by the image analyzer (CUE-2, Olympus, USA). The results were summarized as follows :
1) There was no-significant difference in proportions of Ig-positive cells and T cell subsets between tonsils and adenoids.
2) IgG- and IgD-positive cells in the tonsils were significantly increased in cases with recur-rent tonsillitis than in those with simple tonsillar hypertrophy.
3) Number of IgA2-positive cells were significantly changed, i.e., decreased in the subepith-elial area of tonsils and increased in the interfollicular area of adenoids in cases complicated with otitis media with effusion.
4) In cases complicated with nasal allergy, IgE-positive cells were significantly increased inthe interfollicular area in both of those tonsils and adenoids.
These results indicate that the image analyzer will be a breakthrough in quantitative study on the immunohistology of tonsils and adenoids and give us useful informations about roles of the tonsil and the adenoid on the local immunity of the upper respiratory airway.View full abstractDownload PDF (5463K) -
NOBUO MATSUMOTO, HITOSHI SAITO, NORIO MIYOSHI, KAZUO NAKANISHI, MASARU ...1989 Volume 92 Issue 12 Pages 2079-2088
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSWe investigated the time course of Hematoporphyrin oligomer (HpO) uptake to squamous cell carcinoma (SCC) transplanted into C3H mice after intraperitoneal (i.p.) -injection by measuring its fluorescence intensity. The fluorescence intensity was maximum at 83 hr after the i.p.-injection.
The tumors once disappeared by the single application of photodynamic therapy (PDT) or microwave hyperthermia at 83 hr after HpO i.p.-injection. However, all the tumors treated with these single modalities recurred within 4 weeks after the treatments. Therefore, we investigated the therapeutic effect of microwave hyperthermia in combination with PDT at 83 hr after HpO i.p.-injection. As the results, the combination effect was the strongest when high-dose therapy was used as the first choice of therapy, irrespective of the orders of the treatments and no tumor regrowth occured over 45 days after tumor disappearance.View full abstractDownload PDF (2846K) -
KIMINORI SATO, TOSHIRO KAWAGUCHI, HIDETAKA MATSUOKA, MINORU HIRANO1989 Volume 92 Issue 12 Pages 2089-2093
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESS11 patients with advanced nasopharyngeal carcinoma were treated by combination of radiother-apy plus neo-adjuvant chemotherapy using CDDP and PEP.
1. The primary tumor was located at postero-superior wall of the nasopharynx in 6 cases and at lateral wall in 5 cases.
2. According to TNM Classification, the tumor was classified as TI in 1 case, T2 in 4 cases, T3 in 3 cases and T4 in 3 cases.
According to Stage Grouping, the tumor was grouped as stage III in 2 cases and stage IV in 9cases.
3. Clinical results were the following : Response rate was 82%, CR being noted in 1 case and PR in 8 cases for primary lesion. It was 70%, CR in 1 case and PR in 6 cases for lymphnode involvement.
4. 4 patients died of primary lesion and 1 patient, of distant metastasis and 1 patient, of complications. 5-year cumurative survival rate was 45. 5%.
5. This treatment was effective on nasopharyngeal carcinoma up to stage IV, except for T4.View full abstractDownload PDF (323K) -
SHIGEKI NISHIHIRA, EIKO ITO, SHIGERU HANAZAWA, YASUHIRO YOSHINO, KIYOS ...1989 Volume 92 Issue 12 Pages 2094-2099
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSSurgical repair of cerebrospinal fluid (CSF) leak requires the production of a seal competent to resist CSF pressure during the period of healing. Direct suturing, packing with muscle and fat grafts, and coverage with mucosal or muscle flaps have been effective in repairing most CSF leaks Fibrin glue will improve the results of a CSF leak repair by providing better adhesion of the graft and improving the initial seal during healing. Experiments were performed on 39 rats to assess the effectiveness of fibrin glue in repairing experimentally produced CSF leaks. CSF leak was produced by creating defects at the cribriform plate. There were four experimental groups ; 1. no treatment control ; 2. fibrin adhesive alone ; 3. muscle packing alone ; 4. fibrin glue with muscle packing. The CSF leaks were evaluated 3 weeks after repairs. Persistent CSF leakage was noted in 89% of group 1, 55% of group 2, 33% of group 3, and 22% of group 4. The result in the muscle plus fibrin glue group suggests that fibrin glue, by its adhesive sealing properties, improves the results of muscle packing alone for the treatment of nasal CSF leak.View full abstractDownload PDF (1732K) -
YASUSHI FURUTA, MITSUGU KAWANAMI, MASAAKI KASHIWAMURA, HISASHI MIKUNI, ...1989 Volume 92 Issue 12 Pages 2100-2105
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSThirty-four patients underwent thyroid surgery for papillary and follicular adenocarcinomas in the period from 1985 to 1989. Fourteen patients were treated with local neck dissection and 20patients, with modified or radical neck dissection. Cervical lymph node metastasis was found in 25 patients (74%). Our recent policy for lymph node dissection is as follows : When deep cervical lymph node metastasis is clinically demonstrated, radical or modified neck dissection is performed.In patients without clinically demonstrated metastasis, local neck dissection and sampling of the internal jugular chain are performed. When microscopic metastasis is found in frozen sections, modified neck dissection is added. Thus we could select patients for modified neck dissection and choose appropriate neck dissection for more complete cancer clearance without losing postoper-ative functions.View full abstractDownload PDF (814K) -
A CLINICOPATHOLOGICAL STUDYKIMINORI SATO, TOSHIRO KAWAGUCHI, HIDETAKA MATSUOKA, MINORU HIRANO1989 Volume 92 Issue 12 Pages 2106-2112
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSA clinicopathological study of 6 cases of stress ulcer following head and neck surgery treated at Kurume University Hospital from 1986 to 1989 was completed. The results of this study are summarized as follows :
1) 4 cases were male and 2 cases were female. The average age was 71 years.
2) All cases were found after head and neck surgery of malignant tumors.
3) The frequency was 0.3% in all surgical cases, and 1.2% in surgical cases of malignant tumors.
4) Of these 6 cases, 3 cases were found after surgery of maxilla.
5) The majority of stress ulcer occured suddenly and early after surgery.
6) The majority of stress ulcer occured in the upper portion of the body of stomach.
7) Operation was performed in all cases.
8) Five cases were cured by surgery. One case was died of cardiac failure.
9) It is important to know that the stress ulcer following head and neck surgery of malignant tumor is not rare, and to take care of it after surgery.View full abstractDownload PDF (2043K) -
[in Japanese]1989 Volume 92 Issue 12 Pages 2154-2155
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (110K) -
[in Japanese]1989 Volume 92 Issue 12 Pages 2156-2157
Published: December 20, 1989
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSDownload PDF (116K)
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