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Volume 103, Issue 12
Displaying 1-6 of 6 articles from this issue
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Tadashi Kitahara, Noriaki Takeda, Yasuo Mishiro, Kazumasa Kondoh, Junk ...2000 Volume 103 Issue 12 Pages 1255-1262
Published: December 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSUnderstanding the appearance of vestibular symptoms during periods of convalescence after surgery for the
treatment of Meniere's disease is important for determining when a patient can return to work as well as the longterm results of the operation. We have treated 20 cases of intractable Meniere's disease with endolymphatic sac drainage & steroid-instillation surgery (EDSS) [Kitahara T, et al., Ann Otol Rhlnol Laryngol in press, 2000] and observed the subjective symptoms and objective vestibular findings using electronystagmogram (ENG) during the subsequent period of convalescence.
The average postoperative durations of subjective static and evoked vestibular symptoms were 1.7 and 6.7 days, respectively. Those of spontaneous, positional and positioning nystagmus observed using ENG were 1.2, 2.0 and 7.9 days, respectively. In cases with a long history of Meniere's disease, postoperative static vestibular sensation and positional nystagmus lasted significantly longer than in cases with short histories. In cases with poorly developed temporal bony pneumatization in the area behind the posterior semicircular canal, postoperative evoked vestibular sensations and positioning nystagmus lasted significantly longer than in cases with well developed temporal bony pneumatization.
Vestibular symptoms resulting from direct invasion during EDSS were considered to be slighter than those resulting from vestibular neurectomy or gentamicin treatment and almost the same as those resulting from endolymphatic sac surgery.View full abstractDownload PDF (929K) -
Suetaka Nishiike, Morihiro Irifune, Takeshi Kubo2000 Volume 103 Issue 12 Pages 1263-1271
Published: December 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSTuberculous otitis media (TOM) is a variable and puzzling infectious disease that is sometimes confused with other chronic middle ear diseases. A series of 7 cases (9 ears) of TOM recently treated at Osaka Prefectural Habikino Hospital is reviewed to assess the recent features of the disease.
In most cases. the pathogenetic mechanism was probably aspiration of tubercle bacilli through the eustachian tube. In most cases. abundant granulations were observed in the middle and external ears, but multiple perforations of the tympanic membrane were not seen. The manifestations were variable, such as otorrhea from the perforation and otitis media with effusion. In their early stage. most cases of TOMs due to transmission via the eustachian tube are tend to resemble otitis media with effusion. Smear tests, culture, PCR, and histopathological examinations, each of which has advantages and disadvantages, must be repeated to achieve a definitive diagnosis. Tuberculin tests can be unreliable, but a chest x ray is indispensable whenever TOM is suspected. Antitubercular chemotherapy and 2% kanamycin earwash yielded good results. Since the classical criteria for the diagnosis of TON are no longer valid, we propose a new criterion for diagnosis in the early stage of the disease.View full abstractDownload PDF (1339K) -
Tomoko Tateya, Kazuo Funabiki, Yasushi Naito, Nobuya Fujiki, Takeshi M ...2000 Volume 103 Issue 12 Pages 1272-1280
Published: December 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSWe surveyed on cochlear implant (CI) users using a questionnaire to determine how they use their CIs in daily life and to what degree they are satisfied with them. We also studied the relationship between the degree of satisfaction and speech perception score, age at operation, and deafness duration.
Subjects were 37, postlingually-deafened adult CI users were subjected to this study. Average CI use per day was 13.6 hours. Some 60% of subjects understood person-to-person conversation without lipreading, but most could not communicate on the telephone, in meetings, or in noisy places, for example.
Most-about 80%-were satisfied with CI, but 20% were not. Those not satisfied tended to be unable to understand person-to person conversation even with CI and lipreading, indicating that understanding person-toperson conversation is one of the most important reasons for satisfaction in CI users. Speech recognition scores improved in all cases after implantation. Most patients with high speech recognition score-> 40% in consonant recognition-were satisfied with CI, but those with recognition scores<40% in consonant recognition, the degree of satisfaction varied. These results indicate that the degree of satisfaction in CI users does not always correspond to the degree of improvement in speech recognition score.
Two patients not satisfied with CI had undergone surgery after the age of 65 years and deafness duration exceeding 20 years. Advanced age and a long deafness duration may thus reduce satisfaction with CIs.View full abstractDownload PDF (1343K) -
A Case ReportKazuhiro Ishikawa, Ko Inoue, Ken Kitamura, Keiichi Ichimura2000 Volume 103 Issue 12 Pages 1281-1283
Published: December 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSWe report a 37-year-old male with bilateral peripheral facial palsy associated with HIV infection. He was serologically tested for HIV and was found to be positive (by Western blot and ELISA). Serum chemistry studies showed elevated HIV RNA and were negative for p24 antigen. The CD4+ count was 533 cells x 106 per liter, with a CD4+: CD8+ ratio of 0.47. Since there was no evidence of any other underlying systemic illness, his facial palsy was considered to be secondary to HIV infection.View full abstractDownload PDF (825K) -
Chikaya Hattori, Tadao Nishimura, Nobuhiro Shibata, Yasutaka Akita, Ke ...2000 Volume 103 Issue 12 Pages 1284-1291
Published: December 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESSUvulopalatopharyngoplasty (UPPP) and nasal CPAP are used for the treatment of obstructive sleep apnea syndrome (OSAS) in different institutions. Although OSAS results from an abnormality in the soft-palate, almost no reports have been made on the selection of UPPP or nasal CPAP procedures according to the type of abnormal-ity. The most probable reason for this is that a comparison of treatment methods in individuals cases is difficult. We performed CPAP titration before and after operations, and compared the treatment methods, and evaluated the medical therapy.
Method: A sleep polygraph was performed on the first night, and cases diagnosed as OSAS received CPAP titration on the second night. The blocked region was identified by endoscopic examination. The results of the operation were evaluated after 1-2 months, and apnea hypopnea index (AHI) improvements of less than 50% received a second CPAP titration.
Results: The operation results were poor for cases where endoscopic examination showed full-circumference palatal type, and good for soft palate and tonsillar type abnormalities. When endoscopic examinations were performed in conjunction with nasal CPAP, the treatment was observed to act on the soft palate and expand the air way in all cases. Nasal CPAP was effective in cases with full-circumference palatal abnormalities because in these cases, the pressure was caused by inflamma. Combined medical treatments were effective in cases where CPAP alone was ineffecive because the pressure was too high.View full abstractDownload PDF (1559K) -
Intracellular Calcium Kinetics after Odorant Stimulus in Olfactory Receptor Cells Isolated from MiceTetsuya Mizutani, Masaaki Sahara, Kiyoaki Kamakazu, Tadashi Hisamitsu, ...2000 Volume 103 Issue 12 Pages 1292-1299
Published: December 20, 2000
Released on J-STAGE: March 19, 2008
JOURNAL FREE ACCESScAMP and IP3 act as secondary messengers in olfactory signal transduction and when activated, stimulate calcium levels in olfactory receptor cells. Little is known however, about the causal mechanism. We studied calcium kinetics in mouse olfactory reseptor cells after odorant stimuli.
Olfactory receptor cells were isolated from female BALB/c mice, treted with trypsin, and stained with Fura-2/AM. Changes in intracelluler Ca2+ concentrations in stained cells were measured with a fluorescent microscopic image-processing device (ARGUS-50; Hamamatsu Photonix, Japan). We found that intracelluler Ca2+ concentra-tions rose after exposure to a set of odorants, including 3-ethoxy-4-hydroxy-benzaldehyde, caprylic acid, heptanoic acid, nonanoic acid, eugenol, phenethyl alcohol, and n-amyl acetate. Adding 2', 5'-dideoxyadenosine, a cAMP inhibitor, beforehand suppressed olfactory receptor cell reponse to odorants. Intracellular Ca2+ concentrations increased substantially in response to stimulation by odorants in calcium-free Ringer's solution, but only a slight increase was seen in intracellular calcium concentration in response stimulation by a high concentration of K+ (145.6 mM) in calcium-free Ringer's solution. The increase in intracellular Ca2+ concentration after odorant stimuli was suppressed when olfactory receptor cells were pretreated with ryanodine, which releases Ca2+ from intracel. lular stores.
These findings suggest that elevated Ca2+ concentrations may be involved in releasing Ca2+ from intracellular calcium stores in mouse olfactory receptor cells, in which cAMP functions as a secondary messenger in olfactory signal transduction.View full abstractDownload PDF (2811K)
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