巻号一覧
29 巻, 1 号
選択された号の論文の4件中1～4を表示しています
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YOICHI TAKABAYASHI, KUNIZO KATAOKA, SHUN MATSUKI1980 年 29 巻 1 号 p. 1-8
発行日: 1980年
公開日: 2009/03/27
ジャーナル フリーKetogenesis is a kind of physiological and biochemical imbalance between glycogenolysis, gluconeogenesis and lipolysis, which are delicately regulated by several hormones. The purpose of these experiments in rats is whether the administration of epinephrine, which has potent actions on glycogenolysis and lipolysis, can make the similar ketogenic state as glucagon or anti-insulin serum and how α- or β-adrenergic blockade acts against the rapid effect of epinephrine. As a result, the three hour infusion of epinephrine raised up plasma glucose rapidly and plasma ketones gradually and increased the ketogenic capacity of liver. On this time liver glycogen was exhausted almost completely and liver carnitine was elevated to the same level of fasted rats. The additional administration of α-adrenergic blockade blunted the effect of epinephrine on plasma glucose, plasma ketones and ketogenic capacity of the liver. On the other hand, the additional administration of β-adrenergic blockade aggravated plasma glucose furthermore and had less effect against epinephrine on plasma ketones and ketogenic capacity of the liver. The elevated liver carnitine with epinephrine was not affected by either α- or β-adrenergic blockade. From these findings, we concluded that the rapid ketogenic effect of epinephrine is mainly mediated by a-adrenergic effect of it.抄録全体を表示PDF形式でダウンロード (429K) -
HIROSHI TAKAMI, OSAHIKO ABE1980 年 29 巻 1 号 p. 9-17
発行日: 1980年
公開日: 2009/03/27
ジャーナル フリーThe cytoplasmic proteins of rat liver following exposure to the hepato-carcinogen, 3'-methyl-4-dimethylaminoazobenzen (3'-MDAB) were separated by a two-dimensional gel system using isoelectric focusing in the first dimension and sodium dodecyl sulfate (SDS) gel electrophoresis in the second dimension. After commencement of administration of the carcinogen, the rats were sacrificed at 14 weeks (hepatoma A) just after the occurrence of hepatomas, 16 weeks (hepatoma B), and 22 weeks (hepatoma C), respectively. All three hepatomas have six protein spots that have not been found in normal liver; i.e., 35/7.8 and 20/7.3 (molecular weight × 10-3/isoelectric point) as repre-sentative proteins. Some proteins 72/6.8, 72/6.3, 65/7.3, and 44/7.8 which were present in hepatoma, were found in large amounts in accordance with the tumor growth. The patterns of spots of cytoplasmic proteins in liver showed alterations during the course of carcinogenesis, and finally those of hepatoma C were very different from those of normal liver. These changes in composition of cytoplasmic proteins reflect earlier changes in the rate of synthesis of individual protein species.抄録全体を表示PDF形式でダウンロード (6437K) -
HIROHISA SATO1980 年 29 巻 1 号 p. 19-38
発行日: 1980年
公開日: 2009/03/27
ジャーナル フリーThe kininase activity in the seminal plasma was identified with kininase II (angiotensin-converting enzyme) by thin layer chromatography and its activity of infertile patients was significantly lower than in normozoospermic patients. The amount of proteinase inhibitor in the seminal plasma was 7.0 ± 0.9 trypsin inhibitor unit/ml, however no correlation was found between its activity and semen quality.
The effects of bradykinin and kallikrein on the velocity and motility of washed human spermatozoa were measured by multiple exposure photography method. The addition bradykinin at each concentration of 0.1ng/ml and 1.0ng/ml to the washed spermatozoa resulted in an increase of velocity and motility. The same effect as bradykinin on the spermatozoa was found in the presence of 0.1 KU/ml and 1.0 KU/ml of kallikrein.
In order to determine the effect of kallikrein on the concentrations of seminal fluid components, infertile men were treated orally for 6 months. Following determinations of volume, motility and sperm density, the concen-trations of kininase II, proteinase inhibitor, lactate dehydrogenase and acid phosphatase were measured. Sperm motility and density were increased dur-ing treatment. Mean values of the parameters in the ejaculate unchanged, with the exception of kininase II, which exhibited significantly higher con-centration under treatment.
Of a total of 131 men treated, 23 pregnancies (17.6%) is established be-tween the first and the sixth month.
Thus, present work shows that the components of kallikrein-kinin system participate in spermatogenesis and sperm motility.抄録全体を表示PDF形式でダウンロード (2116K) -
TOSHIHIKO ARAI, SADAO KOMATSU, YOKO KOMATSU, YUTAKA TAKASHIMA, HARUO K ...1980 年 29 巻 1 号 p. 39-45
発行日: 1980年
公開日: 2009/03/27
ジャーナル フリーWe surveyed antibiotic resistances of fecal Escherichia coli strains from healthy human in Tokyo in 1978 and their conjugative R plasmids. Approxi-mately 50% of healthy human had streptomycin/tetracycline resistant E. coli strains in their intestines. In addition, 34%, 28% and 17% of them had ampicillin, kanamycin, and chloramphenicol resistant strains, respectively. Coincidences of various resistance markers of these isolated strains were higher in the closer markers in the linear order of Km-Sm-Tc-Ap-Cm. Incidences of the single drug resistant conjugative R plasmids in the strains selected by tetracycline, streptomycin, kanamycin and ampicillin were found to be high in these years, but the multiple drug resistant conjugative R plasmids were found to be still predominant in the strains selected by chloramphenicol even though the incidences of these strains had been decreasing. These results might be caused by the present selective chemotherapeutic environments.抄録全体を表示PDF形式でダウンロード (347K)
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