巻号一覧
50 巻, 3 号
選択された号の論文の11件中1～11を表示しています
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Arnold J. Levine2001 年 50 巻 3 号 p. 129-133
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーPDF形式でダウンロード (437K) -
Yusuke Nakamura2001 年 50 巻 3 号 p. 134-140
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーPDF形式でダウンロード (6177K) -
Shiaki Kawada2001 年 50 巻 3 号 p. 141
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーPDF形式でダウンロード (39K) -
Kazuhiro Chiba, Yoshiaki Toyama2001 年 50 巻 3 号 p. 142-151
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe outstanding achievements of two renowned spine surgeons, who are alumni of the Department of Orthopaedic Surgery, Keio University, are described. Anterior decompression followed by fusion and laminectomy had been the standard techniques for cervical myelopathy due to disc her-niation, spondylosis and ossification of the posterior longitudinal ligament. However, both techniques were not without certain comorbidities. Dr. Kiyoshi Hirabayashi devised an epoch-making expansive open-door laminoplasty, in which both sufficient posterior decompression and preservation of cervical stability are achieved simultaneously with reduced risk of such complications. Dr. Sadahisa Hijikata is the pioneer of a totally new concept treatment, percutaneous nucleotomy, for lumbar disc herniation, one of the most prevailing diseases that cause low back pain and sciatica. He devised this technique to avoid prolonged conservative treatment with associated suffering of the patients and to minimize the chance of morbidity that is occasionally associated with an open surgery. This technique, together with chemonucleolysis, has led to the establishment of intradical or intermediate treatments which lie be-tween conservative and surgical treatments. Both techniques have not only brought the relief of pain and suffering in numerous patients, but have also opened the door to the development of many new modified procedures and technologies. Most importantly, these two techniques still remain as the most viable choice among various similar modifications. The rationale, indictions, technique as well as the present status and future perspective for these two innovative yet fundamental techniques are intro-duced and discussed.抄録全体を表示PDF形式でダウンロード (2922K) -
Tomoaki Hinohara2001 年 50 巻 3 号 p. 152-160
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーSince the introduction of PTCA in 1977, PCI has evolved significantly. PCI treatment has become main-stream for the treatment of CAD. In addition to signif-icant improvements of basic PTCA equipment, new generation procedures such as DCA, Rotablator and most significantly stents, have improved the outcome of PCI procedures. Although restenosis remains one of the major limitations of this procedure, new approaches including radiation have improved its outcome. Excit-ing technologies such as drug-eluting stents will have significant impact on outcome. It is likely the indica-tions for PCI will continue to expand and PCI will become more effective in the future. Evidence-based medicine will play a more important role to evaluate and guide PCI procedures in the future.抄録全体を表示PDF形式でダウンロード (4107K) -
Hideo Matsumoto, Kyosuke Fujikawa2001 年 50 巻 3 号 p. 161-166
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe features of the Leeds-Keio artificial ligament, which was developed as a collaborative project between the University of Leeds in the UK and Keio University, are introduced. The ligament is made of polyester, and has a mesh structure. The diameter of the polyester fibers is 22μm. The lig-ament has a tensile strength sufficient for anterior cruciate ligament (ACL) reconstruction, and fatigue tests have shown satisfactory durability of the ligament. The stiffness of the Leeds-Keio artificial liga-ment is about 200 N/mm, which is similar to the natural ACL. A combination of a bone plug and sta-pling is used for the bone fixation, taking into consideration the strength in both the initial mechanical fixation and the long term fixation. From an animal study, it was shown that fibrous tissue was induced around the artificial ligament, and the collagen fibers became aligned in the longitudinal direction of the ligament. For the clinical experience, one-hundred and thirty five cases were reviewed. The Lachaman sign disappeared in 87.4%, and the pivot shift sign disappeared in 88.1%. Side-to-side dif-ference of anterior displacement of the knee, measured with a KT-2000 knee arthrometer at 30 degrees of flexion, was less than 3 mm in 85.9%. More than 90% of the patients experienced full range of motion. Thus, from the clinical results, it can be concluded that reasonable stability was obtained with the operation. If the Leeds-Keio artificial ligament may not be the perfect substitute for the ACL, both experimental and clinical studies indicate that it represents a major forward step in the history of knee ligament surgery.抄録全体を表示PDF形式でダウンロード (3457K) -
Toshiharu Furukawa, Masahiko Watanabe, Soji Ozawa, Yoshihide Otani, Go ...2001 年 50 巻 3 号 p. 167-174
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーMinimally invasive surgery, has rapidly changed the performance of surgical practice in a wide range of surgical specialities in the last decade of the 20th century. The marked progress in endoscopic surgery has been conducted especially in general and digestive surgery. The Department of Surgery, School of Medicine, Keio University has contributed to the development and establishment of endoscopic surgery in every subspeciality of general and digestive surgery. Our achievements include the development of original methods for laparoscopic wedge gastrectomy and endoscopic thyroi-dectomy, establishment of surgical techniques in endoscopic surgery for esophageal, gastric, colorectal and hepatobiliary diseases, and the introduction of robotics and tele-communicative technologies to endoscopic surgery.抄録全体を表示PDF形式でダウンロード (3718K) -
Tatsuya Murai, Mineko Baba, Ayako Ro, Naoko Murai, Yoshihiro Matsuo, A ...2001 年 50 巻 3 号 p. 175-181
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe Tokyo Metropolitan Government has a medical examiner system, in which all cadavers classified as “unusual death” in the city of Tokyo should be examined, and if necessary, autopsied to determine the cause of death. Of about 10, 000 unusual deaths examined per year, two thirds are usu-ally determined to have died of natural causes. The most common cause of sudden natural death is ischemic heart disease, especially acute myocardial infarction. Pathological examination, however, proves acute myocardial ischemia in only one third of autopsies. Subarachnoid hemorrhage and intra-cerebral hemorrhage, acute myocarditis and cardiomyopathies and aortic dissection/aneurysm as well as pulmonary thromboembolism are frequent causes of death in medical examiner cases. Both patholog-ical and socio-medical problems associated with these diseases are discussed. (Keio J Med 50 (3): 175-181, September 2001)抄録全体を表示PDF形式でダウンロード (2157K) -
Takahiro Sasaki, Junnichi Hamada, Mamoru Shibata, Nobuo Araki, Yasuo F ...2001 年 50 巻 3 号 p. 182-187
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーWe examined the relationship between nitric oxide (NO) production and delayed neuronal death (DND), in the rat hippocampus induced by 21 minutes of transient global ischemia produced by the occlusion of both of the common carotid arteries combined with systemic hypotension. NO pro-duction during ischemia and reperfusion was investigated by quantifying the nitrite (NO2-) levels of the in vivo microdialysis samples collected every 3 minutes from the hippocampus. To determine the origin of NO production, we studied the effects of the focal administration of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of the constitutive NO synthase (NOS). We also carried out systemic administration of a selective neuronal NOS inhibitor, 7-nitroindazole (7-NI). Rats were grouped as follows: group 1 (n=22), vehicle; group 2 (n=19), L-NAME; group 3 (n=12), 7-NI; and group 4 (n=12), a sham operation. The role of NO in the hippocampal DND was investigated histo-logically one week after ischemia. The level of NO production was significantly decreased in groups 2 and 3 as compared to group 1 in which NO production was significantly increased (p<0.05). The density of remaining neurons in the CAI area was significantly reduced only in group 1 (p<0.01). Taken together, it can be concluded that NO production by neuronal NOS during ischemia and reperfusion resulted in DND in the CAI region of the rat hippocampus.抄録全体を表示PDF形式でダウンロード (1586K) -
William D. James2001 年 50 巻 3 号 p. 188-191
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe skin is a well-known reflection of internal disease states. It provides the astute clinician with clues that lead to the diagnosis of systemic illness. While skin disease is rarely life-threatening, serious morbidity and mortality may be avoided by early recognition of subtle cutaneous signs signaling internal problems. The recent literature was reviewed to glean new findings that either added new associations to older syndromes or described completely new diseases. While entire books are written regarding the “Skin Signs of Internal Disease”, this article focuses only on the newest of such findings.抄録全体を表示PDF形式でダウンロード (1146K) -
Nigel W. Daw, Christopher J. Beaver2001 年 50 巻 3 号 p. 192-197
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThere is a shift in ocular dominance of cells recorded in the visual cortex which occurs after closure of one eye during a critical period lasting from eye opening to puberty. Three criteria distin-guish factors that are crucially related to ocular dominance plasticity: 1) the factor should be more concentrated or active at the peak of the critical period; 2) dark rearing, which makes the cortex less plastic early in the critical period and more plastic late in the critical period, should have a similar effect on the factor, and 3) antagonists or inhibitors of the factor should block ocular dominance plasticity. The second criterion can be used to distinguish activity-related factors that may simply increase or de-crease with development from factors that are more specifically related to plasticity. Two factors cur-rently fulfill these criteria, namely N-methyl-D-asparate (NMDA) receptors and protein kinase A (PKA). PKA and NMDA receptors are linked through calcium, since calcium influx through the NMDA receptor increases the production of cyclic AMP by calcium-sensitive adenylate cyclase, which in turn activates PKA. PKA is specifically involved, since protein kinase G and protein kinase C antagonists do not inhibit ocular dominance plasticity. However, NMDA agonists and PKA activators by themselves are not known to bring back plasticity. Thus there may be two or more pathways for ocular dominance plasticity acting in parallel with each other: for example, metabotropic glutamate receptors may act in parallel with NMDA receptors to change calcium levels within the cell.抄録全体を表示PDF形式でダウンロード (444K)
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