巻号一覧
32 巻, 1-2 号
選択された号の論文の5件中1～5を表示しています
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SOICHIRO NOMURA, NOBUYUKI UKEI, SHIROH SAKAIDA, TSUNEYUKI NAKAZAWA1983 年 32 巻 1-2 号 p. 1-7
発行日: 1983年
公開日: 2009/03/27
ジャーナル フリーRecently, β-adrenergic receptor binding has been measured in the brains of various animals by direct receptor binding technic. However, the procedure slightly differs for each animal even among the same species. We tried to characterize β-adrenergic receptor binding in a mouse pallium using 3H-dihydroalprenolol (DHA) as radioligand. The results are as follows (1) 3H-DHA binds to the tissue suspension from mouse pallium in a time dependent manner, but this binding rapidly attains plateau, (2) β-adrenergic agonists and antagonist compete for 3H-DHA binding sites in the same order with known affinity for β-adrenergic receptor, and (3) binding is fully saturated, with high affinity and stereoselectivity for an adrenergic agonist. These findings indicate that 3H-DHA specific binding sites represent the β-adrenergic receptors. We concluded that it is possible to identify the β-adrenergic receptor in mouse pallium applying almost the same conditions as for rat.抄録全体を表示PDF形式でダウンロード (332K) -
MITSUHIRO KAMAKURA1983 年 32 巻 1-2 号 p. 9-24
発行日: 1983年
公開日: 2009/03/27
ジャーナル フリー1008 Japanese males and 891 females are subjected to the measurement of 21 trace elements in their hair, measurement being made mainly by the ICAP method and the interrelationship among these elements are discussed. For these trace elements, 20 element ratios are calculated that are of interest to the author or considered as worth recording, including Ca/Mg, Na/K, Zn/Cd and Hg/Se and the representative values are determined statistically. For each combination of elements, difference due to sex are examined. The ratio of Ca/Mg is found to be influenced minimally by the difference in the age or sex while the ratio of Hg/Se is significantly influenced by the sex. Thus it is shown that some trace elements exhibit similar trend both when alone and when paired with another element while others do not. As for the difference between male and female, Ca/Pb, Cu/Mo, Ca/Cd and Ca/P ratios are significantly higher in female and Hg/Se and Fe/Mn in male. In this paper, academically valid screening levels are mentioned for typical trace element ratios in the hair of Japanese for the first time.抄録全体を表示PDF形式でダウンロード (963K) -
NAOHITO YAMAGUCHI1983 年 32 巻 1-2 号 p. 25-33
発行日: 1983年
公開日: 2009/03/27
ジャーナル フリーThere is an increasing interest in the possible role of psychosocial environment or life stress as an etiological factor of chronic diseases. When the relationship between psychological stress and a disease is to be studied in human populations, epidemiologic methods are most suitable. A case-control study is one of the most useful methods for such studies. However, the study might lead to a false conclusion, unless confounding variables are taken into consideration. In this paper, the natural history of an ill person who visits a medical facility with a disease caused by stress from psychosocial environment was discussed and two confounding variables were successfully identified, which might cause spurious association between stress and disease when a case-control study was conducted using these hospital patients. First, susceptibility to psychological stress might cause a spurious association if the difference in the psychological process of seeking-medical-aid behavior between cases and controls was not taken into consideration. Second, the study also leads to a false conclusion when psychological stress plays a role not in the biological process of the disease but in the psychological process of the diseased people, through which they decide to seek medical care. For these reasons, patients selected from the general population through health examinations are preferable to hospital patients. If the hospital patients are the only available source for the study, controls should be selected with great care so as to avoid such spurious associations.抄録全体を表示PDF形式でダウンロード (570K) -
SHIRO NOZAWA, KATSUMI TSUKAZAKI, SOJU KURIHARA, KAZUYO TADA, MASAYOSHI ...1983 年 32 巻 1-2 号 p. 35-47
発行日: 1983年
公開日: 2009/03/27
ジャーナル フリーUsing 4 epithelial and 3 non-epithelial malignant tumor cell lines established in our laboratory and a newly devised grading recorder, we monitored the cell volume and the daily changes in the constituent cell populations. We found that epithelial tumor cells tended to become remarkably smaller and uniform in culture. Non-epithelial tumor cells had a larger mean cell volume than epithelial tumor cells.抄録全体を表示PDF形式でダウンロード (2437K) -
AKIRA ONO, TORU HIGASHINAKAGAWA, SHUNZO KONDO, TATSUYA NAKAMURA, HIDET ...1983 年 32 巻 1-2 号 p. 49-57
発行日: 1983年
公開日: 2009/03/27
ジャーナル フリーWe report here the appearance of retrovirus-like particles in cultured thymus cells from patients with myasthenia gravis. Cell from five patients with myasthenia gravis were examined. Histologically three were thymomas and two were thymus hyperplasias. The thymus cells were co-cultured for 7 days with allogenic B cells pretreated with mitomycin C. Retrovirus-like particles were demonstrated by electron microscopy in 4 cases of myasthenia gravis. These particles were detected in thymus epithelial cells. In 4 cases of myasthenia gravis examined, reverse transcriptase activity sedimenting at a density of 1.15-1.17 g/cm3 in sucrose density gradients was eluted in the culture fluids. These results suggest that in myasthenic thymuses, retroviruses that can be induced, following a proliferative stimulus, may be involevd in the genesis of thymic disorders, and in the pathogenesis of myasthenia gravis.抄録全体を表示PDF形式でダウンロード (2317K)
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