巻号一覧
53 巻, 2 号
June
選択された号の論文の8件中1～8を表示しています
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COMMEMORATIVE LECTURES
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Ronald M. Evans原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 53-58
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーPDF形式でダウンロード (144K) -
Yasushi Miyashita原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 59-68
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーPDF形式でダウンロード (410K)
REVIEWS
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Masahito Jimbo原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 69-73
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーThe specialty of family medicine arose out of a combination of American public and professional concerns regarding fragmentation of health care and was intended to foster a type of physician with a scope of clinical competence that would allow the patient, not the disease, to be the focus. Family physicians serve as the patient's personal physician and provide entry to the health care system, provide comprehensive care, maintain continuing responsibility for the patient including necessary coordination of care and referral, and provide care appropriate to the patient's physical, emotional, and social needs in the context of family and community. The specialty is currently second only to internal medicine in size, and makes a significant contribution to patient care and medical education. As family medicine looks to the future, some of its challenges include continuing to attract medical students to the specialty, refine research themes, and gain further acceptance in academic medical centers.抄録全体を表示PDF形式でダウンロード (69K) -
Andrew Leask原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 74-77
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーThe cause of fibrotic disease is unknown. We have undertaken transcriptional profiling of dermal fibroblasts cultured from patients with the fibrotic disease scleroderma (systemic sclerosis, SSc) to identify genes overexpressed in fibrosis and have explored their contribution to the fibrotic phenotype. Connective tissue growth factor (CTGF, CCN2), a member of the CCN family of proteins, is overexpressed in SSc fibroblasts. In adult skin, CTGF is not normally expressed in dermal fibroblasts. However, CTGF is induced during the wound healing response and is constitutively overexpressed by fibroblasts present in fibrotic lesions. The overexpression of CTGF present in fibrotic lesions contributes to the phenotype of scleroderma in that CTGF promotes matrix deposition, and fibroblast adhesion and proliferation. In animal models, whereas either TGFβ or CTGF alone produce only a transient fibrotic response, CTGF and TGFβ act together to promote sustained fibrosis. Thus the constitutive overexpression of CTGF by fibroblasts present in fibrotic lesions would be expected to directly contribute to chronic, persistent fibrosis.抄録全体を表示PDF形式でダウンロード (68K) -
Koichi Matsuo, Neelanjan Ray原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 78-84
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーOsteoimmunology is the emerging concept that certain molecules link the skeletal and immune systems. The transcription factor c-Fos, a component of activator protein-1 (AP-1), is essential for osteoclast differentiation. Mice lacking c-Fos are osteopetrotic owing to impaired osteoclast development. Recent studies suggest that in contrast to this positive role in osteoclastogenesis, c-Fos expression inhibits differentiation and activation of mononuclear phagocytes. Here, we focus on the contrasting roles of c-Fos in the bone and immune lineages. Both osteoclasts and mononuclear phagocytes are derived from common myeloid precursors. Osteoclasts resorb bone, whereas macrophages and myeloid dendritic cells phagocytose microbial pathogens, initiating innate and adaptive immunity. Differentiation of the common precursors into either bone or immune lineage is determined by ligand binding to cell-surface receptors, particularly receptor activator of NF-κB (RANK) for osteoclasts, or Toll-like receptors (TLRs) for mononuclear phagocytes. Both RANK and TLRs activate the dimeric transcription factors NF-κB and AP-1. Yet, c-Fos/AP-1 plays a positive role in osteoclasts but a negative role in macrophages and dendritic cells. Further study is necessary to clarify this dual role of c-Fos.抄録全体を表示PDF形式でダウンロード (232K)
ORIGINAL ARTICLES
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Jun Iwamoto, Yohei Otaka, Kazuhiko Kudo, Tsuyoshi Takeda, Mitsuyoshi U ...原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 85-89
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーThe optimal prevention of osteoporotic fractures in the elderly consists of increasing the bone density and preventing falls. We report on the efficacy of training program to promote ambulatory competence in elderly women. Twenty-five elderly women were enrolled in our training program, which is a three-month program consisting of dynamic balance training with Galileo 900 (Novotec, Pforzheim, Germany) once a week, combined with daily static balance (standing on one leg like a flamingo) and resistance (half-squat) trainings. The mean age of the participants was 72.8 years (range, 61-86 years). After 3 months of training, the step length, knee extensor muscle strength, and maximum standing time on one leg were significantly increased, while the walking speed and hip flexor muscle strength were not significantly altered. During the study period, no serious adverse events such as new vertebral fractures or adverse cardiovascular symptoms were observed in any participant. The present preliminary study shows that our training program may have the potential to promote ambulatory competence in elderly women.抄録全体を表示PDF形式でダウンロード (111K) -
Makoto Chuma, Norihisa Saeki, Yoshiya Yamamoto, Tsutomu Ohta, Masahiro ...原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 90-97
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーHepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. To investigate the detailed genetic mechanisms in cancer metastasis, we compared the expression profiles of 20 HCCs with intrahepatic metastasis and 10 HCCs without intrahepatic metastasis using an oligonucleotide array. Of the approximately 12600 genes that were analyzed, we identified 34 genes whose expression levels were significantly correlated with intrahepatic metastasis (P < 0.05). Of these genes, we further investigated the expression of high-mobility group I(Y) [HMG-I(Y)] protein. Real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) confirmed that HMG-I(Y) was up-regulated in HCC with intrahepatic metastasis, compared to its level in HCC without intrahepatic metastasis. Further immunohistochemical examination of HMG-I(Y) revealed a significant over-expression in HCC with intrahepatic metastasis, compared with that in HCC without intrahepatic metastasis (P < 0.05). These results indicate that the molecular signatures of HCC with intrahepatic metastasis and of HCC without intrahepatic metastasis are clearly different. HMG-I(Y) expression was associated with intrahepatic metastasis and may be a predictive marker of HCC intrahepatic metastasis.抄録全体を表示PDF形式でダウンロード (297K) -
Hidetoshi Ishibashi, Mari Kumashiro, Atsushi Iriki原稿種別: Others
専門分野: Others
2004 年 53 巻 2 号 p. 98-102
発行日: 2004年
公開日: 2005/06/17
ジャーナル フリーMany animal species including humans are endowed with the ability to use biological cues and can extract information by observing other individuals. This study explored whether the macaque monkey could use biological cue to find a hidden target. When the experimenter hid food in one hand and crossed and uncrossed hands quickly, the monkey had no difficulty in finding the food and correctly reached for the baited hand. However, when the food was hidden in one of two cups and the cups were shuffled, the monkey could correctly select the baited cup only at an equal level of luck. These results indicate that the macaque monkey could associate the location of food with a biological cue better than a non-biological cue and keep it in memory when the target was unseen.抄録全体を表示PDF形式でダウンロード (89K)
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