巻号一覧
48 巻, 3 号
選択された号の論文の6件中1～6を表示しています
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Katsuhiko Mikoshiba1999 年 48 巻 3 号 p. 111-123
発行日: 1999年
公開日: 2009/03/27
ジャーナル フリーIn summary, as I mentioned, I have long be focusing on the cerebellum. I first talked about the IP3 receptor in relation to the Purkinje cells. Ca2+ release through IP3 receptor regulates the fertilization, cell division, and dorso-ventral axis formation. It is also involved in learning and memory system.
Gene called Zic is expressed in granule cells that make synaptic contact with Purkinje cells. Zic1 is one of the genes important in cerebellar pattern formation. Zic2 is essential in making our brain. Zic3 is important in the right and left axis formation. Purkinje cell and granule cell positioning are really nicely determined. But we now have two genes that determine the positioning, that may help to form a very nice and beautiful structure of the cerebellum. The principles and evidences obtained through the study of the cerebellum are found to be applied to other part of the brain, presumably because the cerebellum is phylogenetically old and plays an important information processing for motor movement.抄録全体を表示PDF形式でダウンロード (32573K) -
John K. Olynyk1999 年 48 巻 3 号 p. 124-131
発行日: 1999年
公開日: 2009/03/27
ジャーナル フリーHepatitis C is the commonest form of chronic viral hepatitis in most western countries. A significant proportion of patients develop cirrhosis, hepatic failure and hepatocellular carcinoma. The results of controlled trials have shown that interferon α is an effective treatment for hepatitis C. Treatment results in normalization of elevated transaminase levels in up to 50% of patients, although only 15-25% of patients have a sustained response. Recent studies have shown that iron influences the response of chronic hepatitis C to treatment and the natural history of hepatitis C. The mechanisms responsible for the effects of iron are not clear but emerging data suggest that the cellular location of iron within the liver lobule and the subsequent effects on immune function are likely to be critical determinants for these effects. It is likely that therapies for chronic hepatitis C which either remove iron or interfere with the action of iron at the cellular level may not only prove useful clinically but may also elucidate further the mechanisms of cellular injury in this disease.抄録全体を表示PDF形式でダウンロード (7243K) -
Tuula Tamminen, Pälvi Kaukonen1999 年 48 巻 3 号 p. 132-139
発行日: 1999年
公開日: 2009/03/27
ジャーナル フリーThis article describes a new integrated child psychiatric family ward treatment model at the Tampere University Hospital. Theoretically, the treatment is based on an integration of systems and psychoanalytical theories as well as behavioral approach. A centerpiece of the model is a 3-week treatment period for the whole family at the family day ward. The work of the multidisciplinary team on the ward focuses on family relationships, on representational level, and on the interactional behavior of the family. Interaction and relationships are also used as tools, including a reflective working model and sharing concrete interaction with the family. So far, the family ward has offered 165 family treatment periods for 113 different families. Altogether in 63% of the total treatment periods one or both parents have had mental illness and in 15% of the total treatment periods there have been serious custody disputes with accusations of sexual abuse of the child. Helping these multi-problem families is a special challenge for our treatment model and at the moment we are developing new methods for assessment and support of parenthood.抄録全体を表示PDF形式でダウンロード (610K) -
Richard A. Shiells1999 年 48 巻 3 号 p. 140-146
発行日: 1999年
公開日: 2009/03/27
ジャーナル フリーRetinal ON-bipolar cells possess a metabotropic glutamate receptor linked to the control of a cGMP cascade, which functions to generate high synaptic amplification of rod signals under darkadapted conditions. We report that a major component of light adaptation of the rod visual system results from a reduction in gain in synaptic transmission from rods to ON-bipolar cells, initiated by Ca2+-loading when the cGMP-activated channels of the postsynaptic cell open with light. When intracellular Ca2+-buffering was reduced adaptation was induced in ON-bipolar cells by background light too weak to significantly desensitize rods, a property absent in OFF-bipolar cells. Desensitization of ON-bipolar cell flash responses was induced by raising intracellular free Ca2+.抄録全体を表示PDF形式でダウンロード (663K) -
Yutaka Sakurai, Noriko Hattori, Takefumi Kondo, Koji Teruya, Naoki Shi ...1999 年 48 巻 3 号 p. 147-150
発行日: 1999年
公開日: 2009/03/27
ジャーナル フリーSubjective health and alcohol intake are important predictors of mortality. There have been few epidemiological studies, however, of the relationship between alcohol consumption and subjective health among the Japanese. The purpose of this study is to investigate the association between alcohol consumption and subjective health. The study subjects were 2, 020 Japanese male employees, who were free from serious disease conditions. The data on subjective health and alcohol consumption were obtained by means of self-reported questionnaire. The subjects who responded “poor health” in the answer to the question about the subjective health status were considered to be in ill-health. Ethanol intake per day was calculated by multiplying the frequency of drinking by the ethanol intake per drinking occasion and summing up for each alcoholic beverage. Age, smoking status, physical activity, and sleeping hours were treated as confounding factors. As a result, subjects who consumed 25-36 or 49g ethanol or more per day had a significantly lower risk of self-rated ill-health compared with those who had never drunk, and a significantly inverse trend was found independent of age, smoking status, physical activity, and sleeping hours. In conclusion, moderate drinkers have a lower risk of self-rated ill-health among Japanese male employees investigated.抄録全体を表示PDF形式でダウンロード (361K) -
Tilo Held, Ian R. H. Falloon1999 年 48 巻 3 号 p. 151-154
発行日: 1999年
公開日: 2009/03/27
ジャーナル フリーFamily therapy of schizophrenia has long been conceived and practised under etiological premises. Familial disturbances as pathological regression/fixation (psychoanalytical) and individuation-impairing family dynamics (systemic) were addressed directly in the hope of “curing” the disorder. The efforts to prove the viability of the concepts and/or the efficacy of the therapeutic approach were largely unsuccessful. Newer strategies of family therapy of schizophrenia are both more precise in their theoretical assumptions and more performing in the pursuit of their therapeutic goals. We analyse the basis of modern family therapy in the “Expressed-Emotions (EE)”-research and propose a newer, more adequate understanding of the EE phenomenon. From our own studies and from a general review of relevant studies we derive an understanding of the rationale of family work and family therapy of schizophrenia. We discuss the results of a meta-analysis on the active ingredients and the conditions of efficacy of family interventions.抄録全体を表示PDF形式でダウンロード (2879K)
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