巻号一覧
37 巻, 2 号
選択された号の論文の6件中1～6を表示しています
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William R. Vogler1988 年 37 巻 2 号 p. 122-131
発行日: 1988年
公開日: 2009/03/27
ジャーナル フリーAlthough advances have been made in the treatment of acute myelogenous leukemia, the 5 year survival for all patients ranges from 4-14%. Survival is increased for those patients obtaining a complete remission. Although the majority of patients are more than 60 years of age, many studies report median ages of less than 50. Exclusion of elderly patients improves results, but treatment of the older population remains a major problem. Allogeneic bone marrow transplantation is restricted to the younger population and thus has no impact on the problem. Prognostic variables at diagnosis which are important in the elderly included: elevated leucocyte count, increased anemia, anticedent hematologic disorder, underlying pulmonary disease, bleeding, and abnormal cytogenetics. The importance of cytokinetic measurements is controversial. Approaches to treating the elderly patients have included using less intensive chemotherapy programs, more intensive chemotherapy to shorten the period of aplasia, and alternate drug therapy. These approaches have not significantly increased the remission rate. Studies have indicated that the elderly fail to achieve remission because of death due to infection occuring during the induction period. Prophylactic antimicrobial programs and clinical trials addressing the prompt treatment of infections offer an approach which could improve the remission rates in the elderly.抄録全体を表示PDF形式でダウンロード (530K) -
田中 耕太郎, 後藤 文男, 五味 慎太郎, 高嶋 修太郎, 美原 盤1988 年 37 巻 2 号 p. 132-143
発行日: 1988年
公開日: 2009/03/27
ジャーナル フリーThe potential influence of the cerebral circulation on measurements of the cerebral glucose metabolic rate by the 14C-deoxyglucose (DG) method originally developed by Sokoloff et al. was evaluated. Their definition of the transport rate constants for hexose by the Michaelis-Menten equation is expected to be theoretically valid as long as the cerebral extraction fraction of glucose (E) remains below 0.18. However, the present computer-simulation study revealed that E may be higher than 0.18 at a cerebral plasma flow (F) of less than 0.70ml/g/min, if Vmax (the maximum transendothelial transport rate of glucose)=F+2 or Vmax=3.5xF+0.7 is assumed based on the studies of Cremer et al. or Gjedde and Diemer. The definition of the transport rate constants for hexose was therefore modified using an exponential equation to incorporate the flow factor. A comparison was made between Sokoloff et al.'s method and the modified method employing the flow-dependent rate constants as defined above. It became clear that Sokoloff et al.'s method using the normal rate constants can significantly overestimate the glucose metabolic rate at a cerebral plasma flow (F) of less than 0.10ml/g/min, while only a minimal error was noted at F higher than 0.30ml/g/min. These findings suggest that any application of the 14C-DG method to the brain suffering from low perfusion should be carefully designed.抄録全体を表示PDF形式でダウンロード (469K) -
都築 達, 藤岡 正, 福田 宏之, 大木 和明, 川崎 順久, 紀太 康一1988 年 37 巻 2 号 p. 144-154
発行日: 1988年
公開日: 2009/03/27
ジャーナル フリーThis study was performed mainly to clarify the vibratory mode in the muscle layer of the vocal fold, and also to observe how the muscle layer affects the vocal fold vibration itself during phonation. Experimental sound was produced with the use of canine larynges. As contrasting media, lead pellets were inserted into various areas of the vocal fold-under the epithelium, inner layers, and in the deep inner (muscle) layer. To collect various data on this experiment, we used an X-ray stroboscope developed at our laboratory, driven by a trigger from a laryngostroboscope. Experimental sound was produced in each of the following conditions: (1) when all internal laryngeal muscles were activated, (2) when all internal laryngeal muscles except the crico-thyroid were activated, (3) when only the cricothyroid was activated. Pellet movements were taken fluorocinematographically and later analyzed with a film motion analyzer. In all of the above three cases, regular movements were not observed in the pellets inserted into the muscle layers. From these above-mentioned results, it was concluded that the muscle layer might not necessarily play an important role as a vibratory body for producing sound while, on the other hand, the motion of the epithelium membrane of the vocal fold may be more essential in producing sound.抄録全体を表示PDF形式でダウンロード (1907K) -
Peter W. Heald, Richard L. Edelson1988 年 37 巻 2 号 p. 155-167
発行日: 1988年
公開日: 2009/03/27
ジャーナル フリーPhotopheresis is a relatively safe and technically simple modality for immunomodulation. The extracorporeal activation of a drug with UVA constitutes a novel form of drug delivery. The usefulness of this system in erythrodermic CTCL is well established. Immunomodulating therapy can thus be conducted outside the host where controlled conditions permit cellular manipulations not possible in the intact patient. Indeed, if one wished, as we did, to develop a system capable of stimulating an immunological response to damage, reinfused lymphocytes, the use of an extracorporeally photo-activated drug presents a distinctive special advantage. Because the only blood components immediately impacted by the photoactivated drug will be those in the extracorporeal system, mononuclear leukocytes localized to the reticuloendothelial system will be uninhibited by the drug. Therefore, unlike with classical chemotherapy which exposes the total body to the effects of the drugs, photopheresis leaves the reticuloendothelial system intact and capable of responding to the reinfused cells. This system is an excellent paradigm for future immunomodulating therapies of malignant diseases.抄録全体を表示PDF形式でダウンロード (2360K) -
Per Brandtzaeg1988 年 37 巻 2 号 p. 168-176
発行日: 1988年
公開日: 2009/03/27
ジャーナル フリーPDF形式でダウンロード (372K) -
碧井 猛, 岡田 太皓, 皆川 公延1988 年 37 巻 2 号 p. 177-182
発行日: 1988年
公開日: 2009/03/27
ジャーナル フリーThis study deals with the first preliminary survey on a childhood population in Japan for rare (heritable) chromosome fragile site requiring bromodeoxyuridine (BrdU) in the culture medium for expression. A 12-year-old girl with BrdU requiring chromatid-type fragile site at 10q25 has been detected in a heterozygous fashion among 32 children who have no phenotypical abnormality.抄録全体を表示PDF形式でダウンロード (662K)
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