巻号一覧
40 巻, 3 号
選択された号の論文の8件中1～8を表示しています
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Harold Kalant1991 年 40 巻 3 号 p. 113-117
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーThe primary enzymatic steps in ethanol metabolism to acetaldehyde, acetate and CO2+ water have been known for many decades, but only a few clinical implications were recognized, such as the risk of malnutrition due to use of alcohol as a source of calories, and the use of disulfiram and other ALDH blockers in the treatment of alcoholism. In the last four decades, however, further understanding of alcohol metabolism has led to recognition of the changes secondary to altered NAD:NADH ratio; to ethanol oxidation by, and induction of, the microsomal cytochrome P450HEl system; to fatty acid ethyl ester formation; to the increase in hepatic O2 consumption; and to the formation of acetaldehyde-protein adducts and antibodies to these. This new knowledge has led to important progress in relation to the pathogenesis and treatment of alcoholic liver disease, and to potentially valuable new diagnostic procedures for detecting heavy drinking and incipient alcoholic tissue damage. These advances demonstrate strikingly how basic research into fundamental biological processes can yield important and unanticipated practical benefits.抄録全体を表示PDF形式でダウンロード (3406K) -
船曳 孝彦, 杉上 勝美, 松原 俊樹, 天野 洋, 落合 正宏1991 年 40 巻 3 号 p. 118-122
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーPancreaticobiliary maljunction is frequently associated with biliary carcinoma, whether or not there is choledochal dilatation. In this anomalous condition, pancreatic juice regurgitates and the mixture of bile and pancreatic juice stagnates in the biliary tree. In cystic choledochal dilatation, cancers arise, mainly in the dilated bile ducts, while in patients not having cystic dilatation, tumors arise in the gallbladder.
Gallbladder bile and/or bile duct bile from fifteen cases of pancreaticobiliary maljunction, including five cancer patients, was analysed biochemically and compared with control bile from 6 patients with a normal pancreaticobiliary junction. Bile levels of pancreatic enzymes were extremely high in the anomalous junction group. In the bile duct bile from patients with cystic choledochal dilatation with pancreaticobiliary maljunction, the concentrations of deoxycholic acid (DCA), lithocholic acid (LCA) and unconjugated bile acid fractions were increased regardless of the presence of cancer. Increases of these bile acid fractions, which are known to have a cancer-promoting effect, were also seen in gallbladder bile from the cancer patients without cystic dilatation.抄録全体を表示PDF形式でダウンロード (3231K) -
榎本 耕治, 藤原 潔, 池田 正, 加藤 繁次, 阿部 令彦1991 年 40 巻 3 号 p. 123-128
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーTo assess chemoendocrine therapy in the adjuvant treatment of patients with Stage II or III breast cancer, 228 patients were enrolled in a 12-month trial period from January 1982 to January 1983. One hundred ninety evaluable patients were followed up for five years. The regimen in this trial consisted of intravenous administration of 13mg of mitomycin C per m2 during the operation and 6.5mg of the same drug per m2 on the first day, and oral administration of 600mg of tegafur per m2 alone or supplemented with 13mg of tamoxifen per m2 for two years. No survival advantage was observed with addition of tamoxifen to tegafur in terms of five-year survival (88.7% vs 86.6% for Stage H and 69.9% vs 82.2% for Stage III). However, there was a significant prolongation of relapse-free survival among patients receiving tegafur and tamoxifen as compared with those who received tegafur alone: 72.9% vs 55.8% (p=0.098 in the logrank test).抄録全体を表示PDF形式でダウンロード (352K) -
木下 文彦, 八木 剛平, 猪俣 ともみ, 神庭 重信1991 年 40 巻 3 号 p. 129-131
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーThis study was undertaken to clarify a clinically effective coping style of 13 schizophrenic patients during recovery from an acute psychotic state. Sixteen recovered depressives served as the control group. A comparison of the coping behavior profile between the two groups revealed that changes in physical activity were significantly more frequent in the schizophrenics (62%) than in the depressives (25%).抄録全体を表示PDF形式でダウンロード (191K) -
池内 幸一1991 年 40 巻 3 号 p. 132-138
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーAugmentation of anti-tumor effect of interleukin 2 (IL-2) with sizofiran (SPG) was demonstrated with in vivo and in vitro experiments. C3H/He mice with subcutaneously inoculated X5563 tumor were used as experimental models. IL-2 at a dose of 2×104units per mouse by subcutaneous injection, and/or SPG at a dose of 0.1 g per mouse by intramuscular injection were given every other day for a total of ten times. Tumor infiltrating lymphocytes (TIL) were investigated with the avidin-biotin peroxidase complex method. Cytotoxic activity of mice spleen cells after the therapies against YAC-1, X5563 and MH134 were tested with 51Cr release assay. IL-2 or SPG alone suppressed tumor growth in vivo, although not significantly. Combination therapy with IL-2 and SPG suppressed tumor growth in vivo significantly (p=0.04). Mice treated with the combination survived longer than the mice treated with the single drug (p<0.05) and the controls (p<0.001). Immunohistologically, more TILs were seen in the combination group than the other groups. In the cytotoxicity study, 3 days after initiation of the therapies, augmentation of natural killer (NK) activity was greater by the combination than by IL-2 or SPG alone. After incubation with IL-2, the spleen cells from mice treated with the combination showed higher cytotoxicity against X5563 or MH134 tumors than those treated with the single drug or controls. Obtained results suggested that combination therapy with IL-2 and SPG effectively induced NK cells and lymphokine-activated killer cells in vivo and may lead to greater clinical benefit in the treatment of malignancies.抄録全体を表示PDF形式でダウンロード (3762K) -
斎藤 英胤, 森實 敏夫, 渡辺 哲, 加川 建弘, 宮口 信吾, 熊谷 直樹, 土本 寛二, 土屋 雅春1991 年 40 巻 3 号 p. 139-145
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーChanges of nucleotide sequences and expressions of cellular oncogenes in human hepatoma cell lines, PLC/PRF/5, HCC-M and HCC-T cells, were examined by Southern and Northern blot analyses. The probes used are DNA fragment of myc, N-, H-, K-ras, fos, fms, raf, erb-A, erb-B, and erb-B2 genes and synthetic oligonucleotides corresponding to the part of N-, H-, K-ras genes. The results are as follows. DNA amplification and rearrangement were not detected in these three human hepatoma cell lines. Point mutations at codons 12, 13, and 61 in N- and K-ras genes were not demonstrated in these cell lines. N-, H-, K-ras and myc transcripts were detected in these three cell lines. However, fos gene transcript was detected only in PLC/PRF/5 and HCC-M cells which were derived from hepatitis B related hepatocellular carcinoma and having integrated hepatitis B virus (HBV) DNA. These data showed that there are no specific proto-oncogene expression into RNA except for myc and ras genes, nor DNA rearrangement in these 3 human hepatoma cell lines with regards to at least 10 different oncogenes examined and suggest the relationship between fos gene expression and integration of HBV DNA in host cell DNA.抄録全体を表示PDF形式でダウンロード (6853K) -
Margareta B Møller1991 年 40 巻 3 号 p. 146-150
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーSome patients have vertigo that is more or less constant, associated with varying degrees of nausea, and only relieved by bedrest. This disorder, named disabling positional vertigo (DPV), was found to be caused by a blood vessel or vessels compressing the eighth cranial nerve in its intracranial portion, and it can be relieved by microvascular decompression (MVD) of the nerve. Important in the differential diagnosis of DPV are a detailed history, the results of audiometry (10 to 15 dB interaural threshold difference or a small mid-frequency notch), acoustic middle ear reflex response testing (may be abnormal), and recordings of brainstem auditory evoked potentials (BAEP). BAEP in such cases show increased conduction time in the auditory nerve and/or prolonged latency of wave V recorded from the contralateral ear, possibly the result of brainstem compression. Abnormalities on vestibular testing often do not reflect the severity of the illness. Forty-one patients who underwent MVD to treat DPV in one year at the author's institution have been followed for 4.5 to 5.5 years. By self-evaluation, 20 had excellent and 10 good results of the operation. The success of this procedure is even higher today, since it was found that very small blood vessels, including veins, can cause DPV; thus all vessels touching the nerve are now managed. Complications of MVD are rare. The most frequent, hearing loss, occurred in only one patient in this series.抄録全体を表示PDF形式でダウンロード (1166K) -
Aage R Møller1991 年 40 巻 3 号 p. 151-159
発行日: 1991年
公開日: 2009/03/27
ジャーナル フリーThe author's experiences over the past 6 to 8 years in using the type of neuromonitoring described in this paper during operations in the skull base have shown that this type of monitoring not only decreases the risks for permanent neurological deficits but also makes the work of the surgeon easier and gives the surgeon a sense of security because neural structures that are not visible with the operating microscope can be identified using this method and injuries can be detected instantaneously.抄録全体を表示PDF形式でダウンロード (4066K)
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