巻号一覧
50 巻, 1 号
選択された号の論文の10件中1～10を表示しています
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2001 年 50 巻 1 号 p. 1-4
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーPDF形式でダウンロード (3674K) -
Naoki Aikawa2001 年 50 巻 1 号 p. 5-6
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーPDF形式でダウンロード (152K) -
Atsuo Koto2001 年 50 巻 1 号 p. 7
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーPDF形式でダウンロード (41K) -
Kenichi Takemasa2001 年 50 巻 1 号 p. 8-12
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーJapanese medicine enthusiastically adopted many aspects of Western medicine, especially German, during and after Japan's modernization. After the war, the policy giving priority to German medicine changed greatly, and American medicine replaced German medicine in postwar days. Some people, however, questionwhether it is proper to get medical information one-sidedly from a single country. Faced with the situation of whether German or American medicine should occupythe domi-nant position in Japan, some doctors chose to establish ties with French medicine. Professor Taiei Miura (1901-1995) re-established an intimate relationship, broken off during the war, in the medical field between Japan and France.Much information was to be learned from French medicine, particu-larly in clinical neurology and psychiatry. In this essay, we relate the details of how Miura became interested in French medicine, went to study in France, then contributed greatly to Franco-Japanese friendship.抄録全体を表示PDF形式でダウンロード (1268K) -
Akimichi Kaneko2001 年 50 巻 1 号 p. 13-19
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe transduction in photoreceptors and chemoreceptors has common mechanisms. In photoreceptors, activation of rhodopsin by light triggers the enzymatic cascade mediated by a G-pro-tein, transducin. In olfactory cells activation of the receptor molecule by odorant triggers the enzymatic cascade mediated by aG-protein, Golf. In taste receptor cells biochemical studies have also suggesteda metabotropic transduction hypothesis, but we recently identified a cationic channel that was directly gated by a bitter taste substance. By reviewing these recent studies carried out in our laboratory in the last 10 years, the transduction machinery in these sensory receptor cells are summarized.抄録全体を表示PDF形式でダウンロード (3950K) -
Issaku Ueda2001 年 50 巻 1 号 p. 20-25
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーAnesthesia was a blessing to humankind. It is a miracle that simple molecules such as chloroform (CHCl3). diethyl ether (CH3⋅CH2⋅O⋅CH2⋅CH3), or nitrous oxide (N2O) induce a state of unconsciousness where patients can tolerate surgery. The diversity of the structures of these molecules indicates that there are no common receptors. The action of anesthetics is nonspecific and physical. After the demonstration by Meyer and Overton that anesthetic potencies correlate to their solubility into olive oil, the nonspecific lipid theories monopolized anesthesia theories for almost a century. The dominance of lipid theories invited repulsions against the nonspecificity idea. Protein theories that stress receptor bindings became the top mode. Nevertheless, the wide varieties of anesthetic molecules and the wide varieties of responding systems are difficult to reconcile with the specific interaction concept. This article discusses the recent progress and controversies on the molecular mechanisms of anesthesia. Anesthetics are unique drugs in pharmacology. They affect all macro-molecules. The only comparable drugs are disinfectants. Both are nonspecific drugs. We use alcohols and phenols to wipe off the injection sites. We do not use penicillin or any other antibiotics for this purpose, because they are specific binders. Interestingly, these two nonspecific drugs opened the window for the modern medicine.抄録全体を表示PDF形式でダウンロード (548K) -
Hiroaki Shizuya, Hosein Kouros-Mehr2001 年 50 巻 1 号 p. 26-30
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe development of the Bacterial Artificial Chromosome (BAC) system was driven in part by the Human Genome Project as a means to construct genomic DNA libraries and physical maps for genomic sequencing. The BAC system is based on the well-characterized Escherichia coli F-factor, a low copy plasmid that exists in a supercoiled circular form in host cells. The structural features of the F-factor allow stable maintenance of individual human DNA clones as well as easymanipulation of the cloned DNA. BACs are currently used in a wide array of applications from genome sequencing to gene discovery. This paper describes the key elements in the development of the BAC system and its current notable applications.抄録全体を表示PDF形式でダウンロード (456K) -
Hak Chang2001 年 50 巻 1 号 p. 31-34
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーThe subdermal plexus of the face was angiographically investigated using ten fresh cadavers injected with a radio-opaque lead oxide-gelatin mixture over the entire body. The subdermal vessels were unique in each region of the face, and the author classified the vessels into three kinds according to their running forms, shape of their skin territories, and arrangement of the territories. A kind of line by anastomoses of the subdermal vessels which are mutually adjacent or by the quite elongated sub-dermal vessels was observed. The line depicted by those vessels almost coincided with the relaxed skin tension lines. The author believes that when local flaps in the face are utilized, the flaps should bebetter designed along the line to obtain better blood supply and aesthetic outcome.抄録全体を表示PDF形式でダウンロード (2334K) -
Mark W. Fear, Sarah J. Hatsell, Irene M. Leigh, David P. Kelsell2001 年 50 巻 1 号 p. 35-38
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーRecent genetic analysis of the genodermatoses, in particular the palmoplantar kerato-dermas, has identified the important role of proteins involved in the regulation and formation of epi-dermal cell junctions. There are four major types of junction, of which three have been demonstrated to be important in skin, and in which component proteins such as desmoplakin and connexins are mutated in epidermal disease. These are the gap junctions, desmosomes and adherens junctions. These junctions are responsible for cell-cell adhesion and communication, key properties to maintain the normal cellular phenotype and tissue architecture.抄録全体を表示PDF形式でダウンロード (3036K) -
Richard S. Blumberg2001 年 50 巻 1 号 p. 39-44
発行日: 2001年
公開日: 2009/06/16
ジャーナル フリーIn summary, CD1d is expressed in a polarized manner in biochemically distinct forms on human and rodent IECs. Functional studies in rodents would suggest that activation of CD1d-NK-T-related pathways leads to the generation of immunoregulatory factors that are both anti-inflammatory and barrier-enhancing; characteristics that would be quite beneficial to the perturbations associated with IBD. Our studies would suggest that activation of CD1d on IECs in either an NK-Tdependent or -independent fashion leads to the production of cytokines such as IL-10, which can directly regulate IEC barrier function in an autocrine manner. It is therefore possible that glycolipid antigens, perhaps derived from luminal microbial antigens, may either directly stimulate CDld on IECs or indirectly stimulate IECs through presentation of these glycolipid antigens to local CDld-restricted T cells such as the NK-T cell. These studies further suggest that NK-T cells may be a novel type of immunoregulatory cell relevant to IBD pathogenesis. 23 How these insights relate to immunotherapeutic approaches in IBD remains to be established. However, it is becoming increasingly clear that rationalizing IBD therapy around the sequence of immunologic events associated with IBD pathogenesis is extremely important (Table 1).抄録全体を表示PDF形式でダウンロード (4247K)
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