巻号一覧
59 巻, 2 号
選択された号の論文の5件中1～5を表示しています
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REVIEW
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Yonehiro Kanemura2010 年 59 巻 2 号 p. 35-45
発行日: 2010/06/25
公開日: 2010/07/07
ジャーナル フリーRegenerative medicine using human stem cells is one of the newest and most promising fields for treating various intractable diseases and damaged organs. For clinical applications, choosing which human stem cells to use, i.e. according to tissue of origin and progenitor type, is a critical issue. Neural stem/progenitor cells (NSPCs) hold promise for treating various neurological diseases. We have shown that the transporter protein ABCB1 is predominantly expressed in immature human fetal NSPCs, and thus could be used as a phenotypic marker to investigate and monitor NSPCs in culture. We describe our proposed model for the in vitro proliferative process of aggregated human NSPCs and show that neurosphere enlargement and NSPC proliferation are mutually reinforcing. We have established that human neurospheres contain a heterogeneous cell population, knowledge that will contribute to the development of human neurospheres with desirable characteristics for clinical applications. Furthermore, decidua-derived mesenchymal cells (DMCs), which we isolated from human placenta, have unique properties as mesenchymal stem cells. They also generate a pericellular matrix (PCM-DM) that supports the growth and pluripotency of human embryonic stem cells and induced pluripotent stem cells (hiPS) cells. The newly developed re-programming techniques for generating hiPS cells should greatly contribute to cell therapies using human pluripotent stem cells, including those derived from DMCs. Our DMC-derived hiPS cells are a promising candidate source of allogeneic hiPS cells for clinical applications. We hope our findings will contribute to the development of cell-culture systems for generating human allogeneic stem cells for clinical use in regenerative medicine.抄録全体を表示PDF形式でダウンロード (979K)
LECTURE
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Nobuyo Hatanaka, Shinichi Matsumoto, Yuji Tanaka, Masahiro Kami2010 年 59 巻 2 号 p. 46-51
発行日: 2010/06/25
公開日: 2010/07/07
ジャーナル フリーIslet cell transplantation is a minimally invasive procedure which effectively controls blood glucose level for diabetic patients but is considered as experimental. After islet transplantation, type 1 diabetic patients could become insulin free with stable glycemic control. But for long term effects, only stable glycemic control was maintained and not insulin free status. In 2004 Kyoto University performed the first Japanese islet cell transplant using non-heart beating donor. Of note, due to the lack of cadaveric donors in Japan, the same group performed the world's first successful case of living donor islet transplantation in 2005. Both patients achieved transit insulin-independence; however excellent glycemic control was able to be maintained for a prolonged period. Even though the series of islet transplants at Kyoto University showed promising results, the leading scientist did not continue his research in Japan. This was because it is extremely difficult to implement newly developed treatment as a standard therapy in Japan.抄録全体を表示PDF形式でダウンロード (347K) -
9. Revisiting the Blueprint for Reform of Medical Education in JapanR. Harsha Rao, Kanchan H. Rao2010 年 59 巻 2 号 p. 52-63
発行日: 2010/06/25
公開日: 2010/07/07
ジャーナル フリーReform of medical education at Keio University has been underway since 2003. We measure the progress made since then in five specific categories that span fifteen recommendations presented in our“Blueprint for Reform” at the outset of the effort. These are effectiveness of leadership, curriculum reform, recognition of teaching, clinical competence, and comprehensive training in general internal medicine (GIM). First, effective leadership is being sustained through a succession of Deans, although a potentially crippling loss of leadership in the Department of Medical Education must be offset through timely appointment. Second, curriculum reform is awaiting the implementation in 2012 of an integrated, organ system-based curriculum with an emphasis on ward clerkships, but the introduction of PBL has been delayed indefinitely. Third, teaching is being recognized through the use of student feedback to reward good teachers and through funds for six full-time equivalent salaries dedicated to medical education, but promotions still depend exclusively on research, without consideration of teaching ability. Fourth, clinical skills training is still lacking, although enthusiasm for it seems to be building, thanks to the presence on the wards of a (still miniscule) cadre of dedicated teachers. Finally, exposure to GIM remains non-existent; however, visionary leadership in a newly-independent Emergency Department and the wide variety of medical problems seen there provide a remarkable opportunity to craft a uniquely Japanese solution to the problem. The changes implemented to date are impressive, and we remain enthusiastic about the future, even as we recognize the magnitude of the task that lies ahead.抄録全体を表示PDF形式でダウンロード (424K)
CASE REPORT
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Atsutoshi Tsuji, Michiko Sasaki, Toru Ishii, Seiji Sato, Hideaki Kanki ...2010 年 59 巻 2 号 p. 64-68
発行日: 2010/06/25
公開日: 2010/07/07
ジャーナル フリーThis report describes the long-term (23 years) follow-up of a pediatric patient with acute lymphoblastic leukemia and eosinophilia who underwent multiple valve replacements. An 8-year-old boy with this complex disease was admitted in January 1984 and treated with 6-week course of vincristine, L-asparaginase, and prednisolone, which induced complete remission. He developed atrioventricular valvular insufficiency and infectious endocarditis at 13.5 and 17.3 years of ages, respectively, with progressive development of congestive heart failure. At 18.6 years of age, he underwent prosthetic valve replacement of both atrioventricular valves; the mitral valve was replaced with a mechanical prosthetic valve and tricuspid valve with a bioprosthetic valve. Histopathological examination of the ventricular endomyocardium showed extensive fibrous degeneration and persistent infiltration of eosinophils and lymphocytes. The right-side prosthesis was replaced twice, at 22.4 and 29 years of ages, due to degeneration of bioleaflets and thrombosis of the mechanical valve, respectively. Although he tolerated all surgical procedures, he developed liver cancer at 31 years of age and died. Autopsy could not be performed. The present study indicates that a subset of patients in complete remission of acute lymphoblastic leukemia and eosinophilia can show persistent myocardial eosinophilic infiltration and are at risk of late cardiac disease.抄録全体を表示PDF形式でダウンロード (508K)
ERRATUM
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2010 年 59 巻 2 号 p. 77
発行日: 2010/06/25
公開日: 2010/07/24
ジャーナル フリーPDF形式でダウンロード (87K)
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