巻号一覧
34 巻, 4 号
選択された号の論文の6件中1～6を表示しています
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YASUO UEMURA1985 年 34 巻 4 号 p. 195
発行日: 1985年
公開日: 2009/03/27
ジャーナル フリーPDF形式でダウンロード (62K) -
DAVID E. BELL1985 年 34 巻 4 号 p. 196-197
発行日: 1985年
公開日: 2009/03/27
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HIROMICHI ISHIKAWA1985 年 34 巻 4 号 p. 199-210
発行日: 1985年
公開日: 2009/03/27
ジャーナル フリーLethally X-irradiated F1 hybrid mice of some strains do not accept bone marrow transplants from one or another of the parental strains, and normal unirradiated F1 mice often exert resistance against the graft-vs-host reaction (GvHR)-associated immunosuppression induced by lymphocytes from a certain parental strain. Moreover, normal F1 mouse spleen cells can respond to parental antigen coded for by the major histocompatibility complex (MHC) and generate cytotoxic T lymphocytes, which specifically kill target cells bearing the homozygous parental MHC antigens, in primary in vitro cultures. All of these phenomena are apparently a violation of the basic law of classical transplantation immunity in which the co-dominant phenotypic expression of histocompatibility gene products in F1 hybrid animals has been established. Therefore, the study on the mechanisms of these phenomena, called hybrid resistance (HyR), embraces many important yet unexplained aspects of transplantation immunity, and offers current immunology an intriguing issue to be explored.
To explore complex genetic events that lead to HyR at cellular level, we have studied in detail the in vitro primary F1 anti-parental cytotoxic responses as well as the F1 resistance against parental lymphocyte-induced GvHR by using various kinds of inbred mouse strains carrying well-characterized genetic background. The regulation of both types of the HyR was found to be controlled in appearance by genes located either in the MHC or non-MHC regions. However, our careful experiments have demonstrated that, in most cases, neither the MHC haplotype alone nor the non-MHC background alone can foretell whether a certain F1 mouse strain exerts the HyR or not. In a certain F1 mouse strain, it has been demonstrated that conspicuous combined action of the MHC and non-MHC genes determines the HyR. Implications of this key observation with respect to the immunologic significance of the HyR, together with the discovery of a new mouse minor H-42 histocompatibility locus, are described in detail in the present review article.抄録全体を表示PDF形式でダウンロード (863K) -
WITH SPECIAL REFERENCE TO THE INFLUENCE OF NEUROLEPTIC ADMINISTRATION ON THE LONG-TERM PROGNOSISGOHEI YAGI, HITOSHI ITOH1985 年 34 巻 4 号 p. 211-219
発行日: 1985年
公開日: 2009/03/27
ジャーナル フリーAlthough it is believed that tardive dyskinesia (TD) is reversible in its early stages, little is known about the long-term effects of the subsequent administration of neuroleptics (NLP). Twenty cases of TD (four men and 16 women, aged 35 to 84, mean 52) who had first been diagnosed between 1968 and 1976, were followed up for an average of 10 years. By 1983, in nine cases (including one patient who died), TD had disappeared; it persisted in six cases (one patient died), and recurred following remission in five (two patients died). After the onset of TD, the administration of NLP was discontinued in eight cases, decreased in six, maintained at the same level in four and increased in two. In most patients whose age at onset was below 60, TD was reversible regardless of the NLP administration pattern. On the other hand, TD persisted in most cases in which the onset age was 60 or more, despite the large numbers in which NLP was discontinued. Nevertheless, recurrence of TD was occasionally observed among the reversible cases, and, in two of these, the condition became persistent. It is, therefore, speculated that the long-term outcome of TD is determined mainly by the age at onset. However, if the continued administration of NLP is combined with aging, reversible TD observed among young patients may recur or become persistent.抄録全体を表示PDF形式でダウンロード (454K) -
AKIRA KONOHANA, YO KAWAKUBO, SHINGO TAJIMA, KEIJIRO KITAMURA, TAKEJI N ...1985 年 34 巻 4 号 p. 221-226
発行日: 1985年
公開日: 2009/03/27
ジャーナル フリーA 40-year-old Japanese male with diabetic scleredema was reported. Histochemical examination revealed that the alcian blue and colloidal iron strains were positive in the dermis, especially in the lower dermis. The biochemical analyses of the 3 horizontally sliced layers of scleredema skin revealed that (1) glycosaminoglycan content was low in the upper and middle dermis, which was chiefly due to the decrease in hyaluronic acid, (2) dermatan sulfate content was constant among the 3 layers, (3) the content of collagen in the upper and middle dermis was higher, and (4) the ratio of type I/type III collagen in the whole involved skin was normal. From these results, we speculate that the increase in collagen content in the upper and middle dermis may be essential for the pathophysiology of the disease.抄録全体を表示PDF形式でダウンロード (2771K) -
EFFECT OF HIGH-DOSE INTRAVENOUS IMMUNOGLOBULINHIROSHI MURAKAMI, MASAO KIKUCHI, KEISUKE TOYAMA, YASUO IKEDA1985 年 34 巻 4 号 p. 227-232
発行日: 1985年
公開日: 2009/03/27
ジャーナル フリーWe have recently observed a case of autoimmune neutropenia and thrombocytopenia of a fifteen-year-old girl. Prednisone was first given, leading to complete remission of thrombocytopenia, but without effect on neutrophil count. Severe thrombocytopenia recurred, however, after repeated upper respiratory infection and the high-dose intravenous immunoglobulin (HDIVIgG) at a dosage of 0.4 g/kg/day was administered for 5 days. There was almost no increase in platelet count, but the neutrophil count became normalized. Prior to splenectomy, HDIVIgG therapy was again performed at a dosage of 0.6g/kg/day. Both platelets and neutrophils were dramatically increased. These observations may help us to understand the mechanism of action of HDIVIgG.抄録全体を表示PDF形式でダウンロード (285K)
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