巻号一覧
33 巻, 4 号
選択された号の論文の5件中1～5を表示しています
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SATORU SHIMA, TOSHINORI KITAMURA, M. R. C. PSYCH, TATSUO SHIKANO, SHOJ ...1984 年 33 巻 4 号 p. 161-165
発行日: 1984年
公開日: 2009/03/27
ジャーナル フリーThe dexamethasone suppression test (DST) was administered to 59 patients with major affective disorders and 19 with other psychiatric disorders. The combinations of two dexamethasone doses (1mg vs 0.5mg) and two cortisol criterion levels (5μg/dl vs 4μg/dl) were adopted. The highest sensitivity (43%) was found with 0.5mg DST at the 4μg/dl criterion level for Major Depression. Our study failed to distinguish Melancholia in DSM III.抄録全体を表示PDF形式でダウンロード (221K) -
HITOSHI HANAUE, TSUTOMU KUROSAWA, YOSHIAKI KITANO, SADAAKI MIYAGAWA, F ...1984 年 33 巻 4 号 p. 167-175
発行日: 1984年
公開日: 2009/03/27
ジャーナル フリーIn 7 postoperative gastric cancer patients, the influence of fat emulsification of N1 (2-tetrahydrofuryl)-5-fluorouracil (FT-207) on lymphatic transport was investigated.
The water in oil type of emulsion of FT-207 (FT-w/o) and enteric coated preparation (FT-G) in 1 gram each calculated in terms of FT-207 were administered orally, and lymph from the thoracic duct fistula prepared in advance and blood from peripheral vein were collected simultaneously with time after the administration to determine the concentrations of FT-207 and 5-fluorouracil.
In FT-w/o, FT-207 concentration showed significantly higher values than those in FT-G in 30-120 minutes after the administration, respectively, both in lymph and blood.
In FT-w/o, 5-FU concentration showed a significantly higher value than that in FT-G in lymph 30-240 minutes and in blood 30-480 minutes after the administration.
Thus, FT-w/o having the excellent activity in lymph and blood transition was considered useful as a adjuvant chemotherapeutic drug for postoperative treatment in gastric cancer.抄録全体を表示PDF形式でダウンロード (491K) -
SEIDO JITSUKAWA, NOBUHIRO DEGUCHI, SHIRO BABA, MASARU MURAI, MASAAKI N ...1984 年 33 巻 4 号 p. 177-184
発行日: 1984年
公開日: 2009/03/27
ジャーナル フリーWith the utilization of new diagnostic techniques consisting of ultrasound sonography (US) and computed tomography (CT) scan, small hypernephromas, previously undetectable by hitherto utilized diagnostic method, have been found with increasing frequency. Herein presented are five such cases of small hepernephroma detected for the past one year or so. Also presented are biological implication of such lesions and the treatment.抄録全体を表示PDF形式でダウンロード (2623K) -
KAORU NAKAMURA1984 年 33 巻 4 号 p. 185-199
発行日: 1984年
公開日: 2009/03/27
ジャーナル フリーIn order to clarify immunological role of bacillus Calmette-Guérin (BCG) in the treatment of bladder cancer, human monocyte-mediated cytotoxicity against human bladder cancer cell lines was determined. The tumor cell lines utilized were: a superficial bladder cancer derived cell line KU7 and an invasive bladder cancer derived cell line T24. Peripheral blood was obtained from 20 healthy volunteers (control group) and 10 patients with bladder cancer. Monocytes were separated from peripheral blood lymphocytes (PBL) by adherence on fetal bovine serum (FBS) coated plastic dishes. Cytolytic effects of monocytes were observed by determining 3H-thymidine (3H-TdR) releasing assay and cytostatic effects were observed by determining 3H-TdR incorporation inhibition assay. The former assay had an inherent disadvantage due to the reutilization of 3H-TdR. Therefore the latter assay was mainly used. The cytostatic effects against T24 in patients with bladder cancer were significantly lower as compared with that from control group (45.6±6.6%, 55.3±9.5%, p<0.05). When KU7 was used as a target, cytostatic effects of monocytes from each source, as determined by the same method, were also observed, however no significant difference in the cytostatic effects was noted. Cytostatic effects against each target of monocytes from control group were then determined, after incubation of the monocytes with BCG of four different strength for varying length of time. The highest cytostatic effect (KU7: 68.4±9.8%, T24: 75.1±10.6%) was observed with 7.5×106 viable units of Tokyo 172 strain BCG with which monocytes from control group and KU7 were cultured for 24 hours. Cytostatic index (C. I.) as calculated by a formula [ 1-cpm (BCG treated monocyte + target) /cpm (untreated monocyte + target)× 100] were 57.5±6.2 (KU7) and 42.7±11.8 (T24) when monocytes from control group were used in comparison with 23.8±8.2 (KU7) and 30.2±17.9 (T24) when monocytes from bladder cancer were used. C. I. of monocytes from control group was significantly higher than that from patients with bladder cancer when KU7 was used as target (p<0.001).
These results indicate a significant role of BCG as a nonspecific immuno modulator and this in vitro study will provide a useful guideline to the treatment of bladder cancer.抄録全体を表示PDF形式でダウンロード (795K) -
KEN MARUMO, MUNEHISA UENO, MASAMICHI HAYAKAWA, SEIDO JITSUKAWA, MASARU ...1984 年 33 巻 4 号 p. 201-209
発行日: 1984年
公開日: 2009/03/27
ジャーナル フリーNatural killer (NK) cells have been demonstrated to be activated by interferon (IFN). However the mechanisms of this activation are still not well known. The aim of this study is to investigate the mechanisms of NKstimulation by IFN against human leukemia cell line K562, human renal cell carcinoma cell line CaKi 1, and human prostatic carcinoma cell line DU145, using the methods of 51Cr-release assay and single cell cytotoxicity assay.
From the results of single cell cytotoxicity assay, frequency of active NK cells among peripheral blood lymphocytes (PBL) against each cell line increased significantly by preincubation of PBL with 2, 000 IU/ml of human beta interferon (HuIFN-β) for 12 hr. Recycling capacity of NK cells was measured combining single cell cytotoxicity assay and 3 hr 51Cr-release assay, using K562 cells as target cells. By this measurement maximal recycling capacity (MRC) increased from 10.9±2.2 to 17.8±2.9 (n=7, p<0.01).
It was concluded that stimulation of PBL with HuIFN-β resulted in increase of active NK cells and recycling capacity, i.e. function of individual NK cells to recycle after killing of the initially encountered tumor cells.抄録全体を表示PDF形式でダウンロード (500K)
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