巻号一覧
43 巻, 2 号
選択された号の論文の7件中1～7を表示しています
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山口 寿夫1994 年 43 巻 2 号 p. 63-74
発行日: 1994年
公開日: 2009/03/27
ジャーナル フリーCalcium is the most widely distributed and inevitably important bivalent ion which has an intimate relation both to functions and structures in living organisms. However, studies on the structural and functional alterations induced under a low calcium condition have been ignored. In the last two decades, to clarify the role of ionized calcium in biology, the morpho-functional alterations in various organs and tissues under a low calcium condition provoked by calcium chelating drugs have been examined. In this paper, the range of results obtained through our experiments will be reviewed and the almost miraculous roles of the calcium ion in biology will be discussed. Most of the presented results offer just the beginning of a new era of the research in this field, therefore further continuous studies can be expected.抄録全体を表示PDF形式でダウンロード (9275K) -
Thomas N Wise1994 年 43 巻 2 号 p. 75-78
発行日: 1994年
公開日: 2009/03/27
ジャーナル フリーAnxiety, depression and insomnia are common conditions among medically ill patients. Such disorders may be reactions to the hospital environment, categorical psychiatric disorders or symptoms of the medical condition. Treatment includes both psychotherapy and rational psychopharmacology that considers both the route ofadministration and side effects of the agent utilized.抄録全体を表示PDF形式でダウンロード (376K) -
Britta Ostermeyer Shoaib, Bernard M Patten, Dick S Calkins1994 年 43 巻 2 号 p. 79-87
発行日: 1994年
公開日: 2009/03/27
ジャーナル フリーWe evaluated 100 referred women with breast implants (n=97) or silicone fluid injections (n=3) into breasts who developed various symptoms. All reported symptoms occurred at a median latency period of 6 years (range 0-24 years) after implantation or injection of silicone. Commonest symptoms were weakness (95%), fatigability (95%), myalgia (90%), morning stiffness (89%), arthralgia (81%), memory loss (81%), sensory loss (77%), headache (73%) and dry eyes and dry mouth (72%). Laboratory results revealed abnormal levels of serum immunoglobulins or complement in 57% and autoantibodies in 78%. Sural nerve biopsy was abnormal in 80% with the major finding of loss of myelinated fibers in 79%. Biceps muscle biopsy was abnormal in 58% with the major finding of neurogenic atrophy in 27%. Ninetysix patients underwent implant removal; 60% of the patients were found to have one or both implants ruptured with silicone spilled into tissue. At time of removal, a pectoralis major muscle biopsy was taken which was abnormal in 89% with the major finding of neurogenic atrophy in 55%. Biopsy of implant capsule was abnormal in 94% showing foreign body giant cells containing retractile material consistent with silicone in 69% whether or not the elastomer shell was ruptured. Silicone can cause a systemic autoimmune disease with a variety of symptoms probably due to a global activation of the immune system. Since our patients had objective laboratory and histologic findings together with a high rate of mechanical implant failure, further investigations are necessary.抄録全体を表示PDF形式でダウンロード (2317K) -
伊藤 義彰1994 年 43 巻 2 号 p. 88-93
発行日: 1994年
公開日: 2009/03/27
ジャーナル フリーThe reduction of blood flow occurring after global cerebral ischemia, designated as delayed postischemic hypoperfusion, is a consquence of various pathological processes. Employing a cardiac arrest model in cats, we evalulated the possible role of thromboxane A2 (TXA2) in reducing the cerebral blood flow (CBF) after transient global ischemia. Twenty cats were divided into two groups, a cardiac arrest group (N=13) and a sham operation group (N=7). Following thoracotomy, cardiac arrest was induced for 30 seconds. The TXA2 receptor antagonist, BAY u3405, was injected at 60 minutes after recirculation. The CBF, brain tissue PO2 (BrPO2), brain tissue pH (BrpH) and mean arterial blood pressure (MABP) were measured continuously. The CBF decreased to 89.6% at 60 minutes after the arrest, suggesting postischemic hypoperfusion. Injection of BAY u3405 significantly increased the CBF and BrPO2, whereas BrpH and MABP remained unchanged. In the sham operation group, the CBF, BrPO2, BrpH and MABP did not change significantly during 10 minutes after drug injection, although the BrPO2 was increased mildly at 10 minutes after the injection. Since the thromboxane A2 antagonist improved the CBF only after the cardiac arrest, thromboxane A2 is thought to be one of the factors causing postischemic hypoperfusion.抄録全体を表示PDF形式でダウンロード (428K) -
泉 義雄, 福内 靖男, 厚東 篤生, 中島 伸二1994 年 43 巻 2 号 p. 94-97
発行日: 1994年
公開日: 2009/03/27
ジャーナル フリーA 27-year-old-woman with paramyotonia congenita was reported. She began to suffer from myotonia since infancy. Myotonia was aggravated by cold, but with intense cooling myotonia did not change to flaccid paralysis. Four generations of her family showed the same symptoms that suggested autosomal dominant inheritance. Neurological examinations revealed no impairments of mental function, cranial nerves and sensory system. Muscular atrophy or hypertrophy was not observed. Percussion myotonia of the tongue and thenar muscles could be elicited at room temperature. Myotonia was aggravated by cold. An oral intake of potassium chloride (7 grammes) did not provoke any muscle weakness or flaccid paralysis. Routine laboratory data and findings of head CT scan, cerebrospinal fluid and electroencephalogram were normal. The nosological distinction between paramyotonia congenita and hyperkalemic periodic paralysis has been debated since 1956. Paralysis induced by cold is thought to be a feature of paramyotonia congenita, thus raising a possible relationships to hyperkalemic periodic paralysis. In our case cold paralysis never occurred spontaneously and could not be provoked by immersion in ice water or by potassium loading. This finding confirms the existence of paramyotonia congenita without cold paralysis and may provide a nosological distinction between paramyotonia congenita and hyperkalemic periodic paralysis.抄録全体を表示PDF形式でダウンロード (2001K) -
Harold Chen1994 年 43 巻 2 号 p. 98-107
発行日: 1994年
公開日: 2009/08/24
ジャーナル フリーIn view of recent advancement in the field of medical genetics, one approach to work-up a dysmorphic patient is to focus on how to study the patient clinically, cytogenetically, and molecularly. A clear understanding about major and minor anomalies, classification and terminologies of errors of morphogenesis, history taking, physical examination, laboratory studies including molecular cytogenetic techniques, genomic imprinting, uniparental disomy, and mosaicism is essential. Several clinical cases from my own experience are provided to illustrate my approach to work-up of dysmorphic patients. Case 1 was a newborn with multiple congenital anomalies (MCA) and a de novo dup (1) (pter→q25::q12→qter). Fluorescent in situ hybridization (FISH) unequivocally identified the duplicated region. Case 2 was a stillborn who had frontonasal dysplasia, arrhinencephaly, and other MCA with 46, XX, -7, +der(7), t(2;7) (q31;q36)mat. Her MCA were due to combined effect of trisomy 2q and monosomy 7q. This case helped to define the physical mapping of the critical region for a mild form of holoprosencephaly to 7q36. Case 3 had a classic de Lange phenotype with genital abnormality and sex reversal (46, XX male). Presence of SRY suggests X-Y interchange during paternal meiosis I. Case 4 was a female with primary amenorrhea, short stature, and 45, X/46, X, idic(Y)/47, X, idic(Y), idic(Y). This case demonstrates the need for molecular analyses to confirm the cytogenetic interpretations and allowed the refinement of the breakpoint in the isodicentric Y and karyotype/phenotype correlations. Case 5 & 6 were half sibs with ambiguous genitalia, minor somatic abnormalities, and dup (X) (p21.2→p22.11)mat. Limited extent of the Xp duplication in these cases allows assignment of the X-linked sex-reversal (SRVX) locus to Xp21.2→p22.11.抄録全体を表示PDF形式でダウンロード (7548K) -
1994 年 43 巻 2 号 p. 130
発行日: 1994年
公開日: 2009/03/27
ジャーナル フリーPDF形式でダウンロード (13K)
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