The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
21 巻, 2 号
選択された号の論文の5件中1~5を表示しています
  • HIROSHI MIZUMOTO
    1972 年 21 巻 2 号 p. 57-71
    発行日: 1972年
    公開日: 2009/03/27
    ジャーナル フリー
    The endometrial cells were taken by modified disposable nylon brush. Cells were observed around the time of implantation. Cytomorphological changes and DNA synthesis were studied.
  • I. HEMIPLEGIC AMYOTROPHY: ITS CLINICAL AND ETIOLOGICAL CONSIDERATIONS
    KOJI SHIGENO
    1972 年 21 巻 2 号 p. 73-88
    発行日: 1972年
    公開日: 2009/03/27
    ジャーナル フリー
    From the results of this study, the author considers the conclusions listed below to be most relevant.
    (1) Sixty-nine per cent of the 100 hemiplegic patients in this study had some degree of muscle atrophy in the involved upper extremities.
    (2) Hemiplegic amyotrophy is muscle atrophy resulting from a central origin.
    (3) Important factors in the etiology of hemiplegic amyotrophy are the interrelationships of vasomotor system dysfunctions and disturbances of the central trophic system of the muscle and/or peripheral nerves.
    (4) The locations of the above-mentioned systems have not been exactly determined, but the author believes that these areas play as important a role in inducing hemiplegic amyotrophy as does the parietal lobe.
    (5) Hemispheric dominance is an important factor in inducing hemiplegic amyotrophy.
    (6) The relationship of hemiplegic amyotrophy to severity of motor im-pairment suggests that (in addition to the possible close proximity of the vaso-motor and central trophic systems to the pyramidal tract) lower motor neurons, involved by upper motor neurons, may possibly induce denervation atrophy.
    To approach the problem of peripheral motor neuron impairment, a follow-ing paper will deal with the author's examinations of hemiplegic patients by means of measuring motor nerve conduction velocities of ulnar nerves, the results of which will be compared with the patients' clinical data.
  • II. MOTOR NERVE CONDUCTION VELOCITY OF THE ULNAR NERVES IN HEMIPLEGIC PATIENTS
    KOJI SHIGENO
    1972 年 21 巻 2 号 p. 89-104
    発行日: 1972年
    公開日: 2009/03/27
    ジャーナル フリー
    (1) MCV of the ulnar nerve was measured to investigate the effects of CVD on peripheral nerves.
    (2) MCV of the ulnar nerve was found to be significantly lower in the involved extremities of hemiplegic patients.
    (3) No relationship was found between hemiplegic amyotrophy and de-crease in ulnar MCV.
    (4) Correlation of the MCV of the ulnar nerve with clinical findings was made.
    (5) The possible factors causing lowered MCV of the ulnar nerve in hemi-plegic patients were commented upon.
    (6) The author's hypotheses as to the etiology of hemiplegic amyotrophy and decrease in ulnar MCV in the involved extremity of the hemiplegic patient were offered.
  • Case Report
    TAKAAKI FUJII
    1972 年 21 巻 2 号 p. 105-111
    発行日: 1972年
    公開日: 2009/03/27
    ジャーナル フリー
    A 25-year-old female case developed severe toxicoderma associated with liver damage after receiving acetylsalicylic acid, sulpyrin and chloramphenicol for upper respiratory infection. Despite treatment with glycylrrhizin, reduced glutathione, ascorbic acid and betamethasone as well as drip infusion of fluids for 11 days, her skin symptoms did not improve and the liver damage was aug-mented. Following administration of large doses of vitamin E (800-1000mg/day) and topical application of vitamin E ointment for 3 weeks, her skin symptoms disappeared completely and 11 weeks after the therapy findings of the liver function tests returned to almost normal.
  • TADAKATSU SHIMAMURA
    1972 年 21 巻 2 号 p. 113-126
    発行日: 1972年
    公開日: 2009/03/27
    ジャーナル フリー
    The immunoglobulin contents and antibody activities were measured in the serum and intestinal tracts of germfree mice after an oral immunization with live vibrio organisms, and, further, the relationship between so-called coproantibody and immunoglobulins in the intestinal tracts of them was studied. All three classes of immunoglobulins, IgG, IgM and IgA, were not detected in the intestinal tracts of untreated germfree mice, but some amounts of IgG and IgM were observed in the serum. After the immunization, predominant response of IgG stood out in the serum of them, and IgA was the only immunoglobulin detected in the intestinal tracts. Agglutinin activities in the intestinal tracts appeared earlier than that in the serum. Complement-dependent anti-bacterial antibodies were found in the serum from an early stage after the immunization, but never in the intestinal tracts. In the separate pattern of the intestinal contents by Sephadex G-200 gel filtration and DEAE cellulose chromatography, so-called coproantibody was always found in association with IgA. Absorption of the intestinal contents with intact vibrio organisms brought on a parallel decrease of their activities between IgA and coproantibody in the sample. Furthermore, a concentration of IgA through Sephadex G-200 gel filtration resulted in an elevated activity of coproantibody in the sample. These results suggest that socalled coproantibody against vibrio is an antibody mainly belonging to IgA class.
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