巻号一覧
35 巻, 4 号
選択された号の論文の7件中1～7を表示しています
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Joseph H. M. Hilgers, Ph. C. Hageman1986 年 35 巻 4 号 p. 235-244
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーA short review is presented on the usefulness of monoclonal antibodies against human milkfat globule membranes in pathology and clinical chemistry for the Cancer Clinic, with particular reference to antibodies reacting with the so-called MAM-3 and MAM-6 groups, as defined by a series of antibodies generated in the Netherlands Cancer Institute.抄録全体を表示PDF形式でダウンロード (486K) -
金子 剛, 藤野 豊美, 中嶋 英雄, 原科 孝雄, 清泉 貴志, 山本 浩, 小野 勇1986 年 35 巻 4 号 p. 245-266
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーOur basic concept of reconstruction after cancer surgery is presented. The goal of plastic and reconstructive surgery in this field is to maintain the patient's quality of life by giving him back what he lost by cancer itself or cancer surgery. From this point of view, primary reconstruction could be widely indicated not only for functional reconstruction but also for morphological reconstruction such as breast reconstruction and safety of this procedure is discussed. The problem of concealing cancer recurrence by flap is also discussed and we concluded that the possibility of hiding a recurrence is very low whereas this procedure could be beneficial to the patient as a palliative treatment providing psychological relief. At Keio University Hospital and her affiliated hospitals, 259 cases of recon-structive procedures using flaps are reviewed. Of these flaps 129 cases are free flaps transfers with microvascular anastomosis and 83% of these flaps are applied in the head and neck region. In other regions, pedicled musculocutaneous and fasciocutaneous flaps are mainly used. In our series free jejunum transfer is the main method for pharyngoesophageal reconstruction and repair of the oral mucosa. The flap selection for reconstruction of other sites, i.e., the scalp, the orbita, the mandible, the skin of the face and neck, the cheek (after total maxil-lectomy), cervical and thoracic esophagus, chest wall, breast and the skin of the groin, perineun and penis is individually reviewed. A few examples of clinical applications are presented.抄録全体を表示PDF形式でダウンロード (3430K) -
藤井 正人, 犬山 征夫, 田中 寿一, 高岡 哲朗, 細田 兵之助1986 年 35 巻 4 号 p. 267-275
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーBoth Cisplatin (CDDP) and Peplomycin (PEP) are effective for head and neck cancer, and the combined therapy of the two drugs exerts effective syner-gistic effects. In the present study, the mechanism of the synergism was examined from a pharmacokinetic aspect. First, the pharmacokinetics of CDDP was studied. CDDP was transformed into protein-bound CDDP in the blood. The half life of CDDP in the alpha phase (up to 2 hours after administration) was 0.99 hour; in the beta phase (up to 150.65 hours after administration) it was 150.65 hours. CDDP was proved to persist in the blood in the form of protein-bound CDDP. The in vitro study revealed that the anti-tumor activity of CDDP against the HeLa cells in plasma decreased with time. This indicated that only non-protein-bound CDDP had an anti-tumor effect. Based upon the above findings, we performed an in vitro experiment to determine if PEP could have some promoting effect on the release of non-protein-bound CDDP, which has anti-tumor activity, from protein-bound CDDP. No such effect was observed. The binding between CDDP and plasma protein appeared to be irreversible, and a mechanism that concurrently used PEP may release non-protein-bound CDDP from protein-bound CDDP was denied.抄録全体を表示PDF形式でダウンロード (244K) -
中村 聰1986 年 35 巻 4 号 p. 276-290
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーThe antigenic heterogeneity of a long term cultured cell line has not been clearly demonstrated. In the present study, monoclonal antibodies (MoAbs) to an established cell line KU-2 derived from a human renal cell carcinoma were used to analyze antigenic variation of KU-2 and its subclones. Characterization of thus produced MoAbs was attempted by determining the binding ability to other established cell lines, by enzyme linked immunosorbent assay (ELISA) and immunohistochemical studies with indirect immunofluorescence technique to find cell surface antigens on KU-2. Five MoAbs (ARC-1, ARC-2, ARC-3, ARC-7, ARC-8) were obtained. With these MoAbs three different antigenic determinants were detected on KU-2. According to the degree of expression of these three antigenic determinants, the presence of antigenic variants of KU-2 subclones was demonstrated. Among these MoAbs, ARC-1 showed high specificity for KU-2, and the antigenic determinant detected by ARC-1 was proven to be shared by each KU-2 subclone.抄録全体を表示PDF形式でダウンロード (2925K) -
Louis M. Aledort1986 年 35 巻 4 号 p. 291-297
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーRecent advances in AIDS research are briefly reviewed. AIDS is now known to be a devastating disease, which is transmitted heterosexually as well as homo-sexually. It is also transfusion-transmitted disease. The causative retrovirus has been identified and now named HIV. Two major approaches to prevent trans-mission of HIV are recommended, ma'_e contraception and elimination of HIV from blood products.抄録全体を表示PDF形式でダウンロード (315K) -
Yonosuke Watanabe1986 年 35 巻 4 号 p. 311-313
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーPDF形式でダウンロード (295K) -
Osahiko Abe1986 年 35 巻 4 号 p. 314-315
発行日: 1986年
公開日: 2009/03/27
ジャーナル フリーPDF形式でダウンロード (318K)
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