1) The serum agglutination reaction, bacterial culture from organs, precipitin test with tissue antigen, and pathological findings in the experimental brucellosis of guinea pigs, rabbits, and mice were investigated, and some descriptions were made about the specificity of the thermoprecipitin test with bacterial antigen.
2) Serum agglutinin titers were found between 1:40 and 1:5120, but were not always parallel to the degree of histological changes of organs.
3) The thermoprecipitin test with bacterial antigen showed specific positive reactions against anti-brucella rabbit immune serum. The precipitin test with tissue antigen extracted from lymph nodes and various organs of the experimentally infected guinea pigs has also been proved to be positive against antibrucella rabbit immune serum, though in lower titers compared with the test with bacterial antigen. This precipitin test with tissue antigen may be an important factor in the diagnosis of brucellosis, if investigated more in details as regard to the specificity.
4) The precipitin test with tissue antigen showed the same cross reaction as the agglutination reaction against the three kinds of anti-brucella rabbit immune serum.
5) The characteristic features of pathological findings of the experimental brucellosis are shown in the formation of suppurative and non-suppurative granulomata, and also in a remarkable proliferative reaction of the reticuloendothelial system as the septic histological reaction.
6) The Hodgkin's disease in man and the experimental brucellosis have been both proved to be positive in the precipitin test with tissue antigen against antibrucella rabbit immune serum, and have a striking resemblance in the histological picture of organs. Moreover, in many cases of the Hodgkin's disease brucella strains were isolated from lymph nodes and various organs. The foregoing facts lead us to believe from the etiological point of view that the Hodgkin's disease may be a certain type of brucella infections.
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