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Volume 109, Issue 6
Displaying 1-6 of 6 articles from this issue
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Yuichiro Kuratomi, Masahiko Katayama, Kazuki Kidera, Seiichiro Hayashi ...2006 Volume 109 Issue 6 Pages 517-523
Published: June 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSLaminin γ2 chain (LN γ2), expressed in human cancer cells and correlated with cancer malignancy, is cleaved by proteases and secreted into circulation. We measured the blood concentration of LN γ2 in patients with head and neck cancer by an immuno-fluorescence assay using monoclonal antibodies against human LN γ2. The normal blood concentration of LN γ2 was estimated to be less than 50ng/ml. Among 60 patients with head and neck cancer, 40 (67%) showed normal LN γ2 concentration less than 50ng/ml and 20 (33%) increased concentration exceeding 50ng/ml. The relative ratio of the number of patients who showed increased LN γ2 concentration correlated with the clinical stages of cancer. The blood concentration of LN γ2 in 24 who initially showed normal concentrations did not change after radical treatments. Five who initially showed increased LN γ2 concentration showed decreased concentration of less than 50ng/ml after radical treatment. Four showed increased LN γ2 concentration after treatment, and presented residual cancer, which killed them. Three of the 4 patients showed marked increase in LN γ2 concentration exceeding 100ng/ml and developed multiple distant metastases to the lung, liver, bone, and skin. The blood concentration of LN γ2 in patients with head and neck cancer may thus indicate the amount of highly malignant cancer cells expressing LN γ2. The blood concentration of LN γ2 could therefore serve as a new tumor marker that might indicate the malignancy of and efficacy of treatments for head and neck cancer.View full abstractDownload PDF (515K) -
Mutsumi Sugiura, Yukio Ohmae, Manabu Mogitate, Yurika Kimura, Nao Maki ...2006 Volume 109 Issue 6 Pages 524-529
Published: June 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSRecent studies suggest that gastroesophageal reflux disease (GERD) may be a cause of globus sensation. However, it is difficult to examine the reflux of acidic gastric contents directly. We hypothesized that the esophageal clearance capacity against reflux acid may be responsible for the clinical symptoms of GERD. The purpose of this study was to investigate the bolus residue and reflux in the esophagus during swallowing in elderly patients and to discuss the relationship between globus sensation and esophageal clearance abnormalities. Videopharyngoesophageal examinations in the prone position were performed in 156 elderly patients with globus sensation (average age: 74.7 years old). Esophageal clearance in the prone position was classified into 4 subgroups according to the movement of a contrast bolus: Group 1, normal; group 2, retension in esophagus; group 3, reflux of contrast bolus within esophagus; group 4, reflux of contrast bolus into pharyngo-laryngeal regions. Group 1 contained 36 cases (23.1%), group 2 contained 8 cases (5.1%), group 3 contained 79 cases (50.6%), and group 4 contained 33 cases (21.2%). Overall, the reflux of a contrast bolus in the esophagus was observed in 112 cases (71.8%). We concluded that decreased esophageal clearance in elderly subjects affects the defense mechanism against acid exposure and may be a risk factor for the appearance of globus sensation. Videopharyngoesophageal examination in the prone position may be an easy and valuable method for evaluating the function of esophageal clearance.View full abstractDownload PDF (1730K) -
Masayuki Tomifuji, Akihiro Shiotani, Takuji Takaoka, Yuko Mori, Takeka ...2006 Volume 109 Issue 6 Pages 530-534
Published: June 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSTotal laryngectomy or laryngopharyngectomy are commonly performed for the treatment of laryngeal cancer or hypopharyngeal cancer. However pharyngocutaneous fistula and cervical esophageal stenosis have been reported as postoperative complications of these procedures.
We used a silicon pharyngeal tube in cases that developed pharyngocutaneous fistula and cervical esophageal stenosis. The pharyngeal tube was useful for controlling aspiration pneumonia and for starting oral feeding in a case of pharyngocutaneous fistula after a total laryngectomy. It was also helpful for starting oral feeding in a case with cervical esophageal stenosis after total laryngopharyngectomy and free jejunum interposition. This patient was able to maintain a good quality of life until re-operation. Adverse effects from the insertion of the tube included a foreign body sensation and pharyngeal pain that was tolerable with the use of NSAIDs for a short time. Silicon pharyngeal tubes are useful for the treatment of pharyngocutaneous fistula and cervical esophageal stenosis.View full abstractDownload PDF (1859K) -
The Effect of Corrective Make up TrainingSaiko Sugiura, Yasushi Fujimoto, Seiichi Nakata, Tsutomu Nakashima2006 Volume 109 Issue 6 Pages 535-537
Published: June 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSFacial appearance is very important for personal identity, and some patients suffer long-term stress as a result of disfigurement caused by facial nerve paralysis and wounds. The psychological aspect of the disease has important implications for the optimal management of patients. In such cases, while aggressive rehabilitation including cosmetic surgery may be useful, cosmetics are also effective for covering visible signs of the disease. A patient who had undergone an operation for a sinonasal tumor was instructed by an expert beautician in the application of make up to correct her facial imbalance and wounds. The 60-item General Health Questionnaire (GHQ60) and the European quality of life 5 dimensions (EQ-5D) VAS were administered before the first application and one month afterwards. The GHQ60 and EQ-5D VAS scores improved after the make up instruction. We suggest that corrective make up training is an effective measure for reducing the psychological load of patients with head and neck tumors.View full abstractDownload PDF (680K) -
[in Japanese]2006 Volume 109 Issue 6 Pages 548-551
Published: June 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSDownload PDF (1059K) -
[in Japanese]2006 Volume 109 Issue 6 Pages 552-553
Published: June 20, 2006
Released on J-STAGE: December 25, 2008
JOURNAL FREE ACCESSDownload PDF (139K)
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