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Volume 91, Issue 4
Displaying 1-17 of 17 articles from this issue
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KOJI HOZAWA1988 Volume 91 Issue 4 Pages 497-501,643
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSTo overcome the difficulty to observe the eustachian tube of the patient with otitis media with effusion, an animal model of otitis media with effusion was induced by the inoculation of soluble immune complex into guinea pig's bulla and its eustachian tube was studied by an immunohistochemical technique. Most of the secretory cells of the additional glands of the eustachian tube were stained with alcian blue and PAS reaction, whereas in the mucous membrane of the eustachian tube such stained cells were approximately one out of ten epithelial cells. On the other hand, dolichos bifrolus agglutinin (DBA) or ulex europaeus agglutinin (UEA-I) positive cells were mainly located in the mucous membrane of the eustachian tube. The inoculation of an immune complex resulted in an aseptic serous effusion and brought about the quantitative as well as qualitative changes in the secretory activity of the eustachian tube. Alcianophilic or UEA-I positive cells increased in number especially in the cartilagenous portion and the pharyngeal orfice of the eustachian tube, however, the increase of such cells was not evident in the bony potion and tympanic orfice of the eustachian tube. In contrast, the DBA positive cells decreased in number since 7th day after injection. These findings indicate that the several kinds of secretory cells with different secretory components showed different distribution in the eustachian tube, which increase or decrease in number in response to inflammation in the middle ear.View full abstractDownload PDF (5413K) -
KISHIKO SUGIYAMA, ISAO TAKIMOTO, SHIGERU INAFUKU, TEIJI TANAHASHI1988 Volume 91 Issue 4 Pages 502-508,643
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSA case of Wolfram syndrome associated with dysphagia is described hereinafter. In 1938, Wolfram reported four patients with diabetes mellitus and optic atrophy. Since then, this syndrome has been recorded over 100 cases, often in association with diabetes insipidus and deafness. Various symptoms are shown in this syndrome, dysphagia or vertigo is however rarely seen. Atrophy of hypothalamic nuclei that progresses gradually, degeneration of the optic nerve, its chiasm and tract, and totally unexpected degeneration of the pons and cerebellum are considered as the pathogenesis of this syndrome.
The patient, twenty-seven year-old female, has been suffering from optic atrophy since the age of fourteen and diabetes mellitus since the age of twenty-three. Dysphagia has developed since the age of seventeen. Dysphagia and dysequilibrium revealed brain stem lesion. As the treatment for dysphagia, cricopharyngeal myotomy was fairly effective. The specimen of the muscle obtained in the operation revealed neurogenic atrophy of muscle.View full abstractDownload PDF (5256K) -
HLA CLASS I AND II SPECIFICITIES OF JAPANESE CEDAR POLLINOSISYUKO KITAO, YASUAKI SADANAGA, MASASHI UNO, NAGAAKI ON, KEISUKE MASUYAM ...1988 Volume 91 Issue 4 Pages 509-515,643
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThirty six patients with Japanese cedar (J.C.) pollinosis and 66 normal controls were investigated for clarifing the specificities of HLA class I (A, B, C, ) and II (DR, DQW, DRW) antigens. The patients consisted of 20 patients allergic to J.C. alone and 16 patients allergic to J.C. and other antigens such as housedust mite and/or orchard grass simultaneously. The diagnosis of the disease was made by clinical symptoms, skin test and nasal provocation test with J.C. and serum IgE antibody titer to J.C. All of the patients were positive to all of these tests, and all of the controls were negative to the tests.
The results were as follows.
1. The incidence of HLA-DQW3 was more higher in the 36 patients than that in the 66 controls.
(Patients: 86.1%, Controls: 65.2%, P<0.05, Pc<0.1)
2. The incidence of HLA-A26 was more higher in 20 patients allergic to J.C. alone than that in the 66 controls.
(Patients: 45%, Controls: 16.7%, P<0.01, Pc<0.05)
3. The incidence of HLA DQW3 was more higher in the 16 patients allergic to multiple antigens contained J.C. than that in the 66 controls.
(Patients: 93.8%, Controls: 65.2%, P<0.05, Pc<0.1)
4. In the patients group, all of the individuals who had HLA-A26 had HLA-DQW3.
From the results obtained, it is considered that there may be a linkage disequilibrium relationship between HLA-A26 and HLA DQW3 in the patients. And it is suggested that the genes concerning with J.C. pollinosis may be located the locus of HLA-DQW3 or close to it.View full abstractDownload PDF (515K) -
HLA CLASS I AND II SPECIFICITIES OF ORCHARD GRASS POLLINOSISYUKO KITAO, YASUAKI SADANAGA, MASASHI UNO, NAGAAKI ON, KEISUKE MASUYAM ...1988 Volume 91 Issue 4 Pages 516-520,643
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSNineteen patients with orchard grass (O.G.) pollinosis and 66 normal controls were investigated for clarifing the specificities of HLA class I (A. B, C) and II (DR, DQW, DRW) antigens. The patients consisted of 3 patients allergic to O.G. alone and 16 patients allergic to O.G. and other antigens such as Japasese cedar, housedust mite and/or ragweed simultaneously. The diagnosis was made by clinical symptoms, skin test and nasal provocation test with O.G. and serum IgE antibody titer to O.G.
All of the patients were positive to all of these tests, and all of the controls were negative to the tests.
The results were as follows.
1. The incidence of HLA-A26 was more higher in the 19 patients allergic to O.G. than that in the 66 controls.
(Patient: 52.6%, Controls: 16.7%, P<0.05, Pc<0.025)
2. The incidence of HLA-DQW3 was more higher in the 19 patients allergic to O.G. than that in the 66 controls.
(Patient: 100%, Controls: 65.2%, P<0.01, Pc<0.02)
3. These results were same as those in Japanese cedar pollinosis. And all of the patients allergic to O.G. who had HLA-A26 were allergic to Japasese cedar.
From the results obtained, it is considered that the resemblance in HLA types may explain a tendency to be sensitized multiply with antigens such as orchard grass and Japanese cedar.
From the aspect of biological function in HLA, it is considered that HLA DQW3 antigens which is one of class II antigens may play more important role in the patients of orchard grass pollinosis than HLA-A26 antigen.View full abstractDownload PDF (470K) -
MEASUREMENT WITH MIDDLE EAR ANALYSERHIROSHI WADA, TOSHIMITSU KOBAYASHI1988 Volume 91 Issue 4 Pages 521-527,645
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSAs the reliability of the conventional tympanometer is insufficient except for the diagnosis of the otitis media with effusion, an attempt is made to develop a new middle ear analyser, which will give us more detailed information. The acoustical and dynamical investigation makes it possible to develop a probe tip which shows the similar dynamical characteristics to the theoretical ones. This probe tip enables the middle ear analyser to measure the absolute variation of the sound pressure level and the phase of the human middle ear with sweep frequency.
The dynamical characteristics of the normal middle ear were measured by this midle ear analyser. At the same time, by applying the combination of the impedance theory of the tube with the kinetic and strain energy theory, the equation of the middle ear corresponding to the output of the middle ear analyser was induced. In this paper, the emphasis was put upon the mechanism of the middle ear analyser and the results of the measurement. The theoretical analysis will be discussed in detail on another occasion.
The results showed that the differences of the ear-drum and ossicular chain condition gave sensitive effect to the sound pressure level curves, although the audiograms of the subjects were nearly the same as the others. This middle ear analyser would have clinical applicability.View full abstractDownload PDF (555K) -
EVOKED ELECTROMYOGRAPHIC INVESTIGATIONSHINJI KITANI, HIROSHI OKAMURA, NAOAKI YANAGIHARA1988 Volume 91 Issue 4 Pages 528-531,645
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSFunctional distribution of the extratemporal portion of the facial nerve was investigated in man using intraoperative evoked electromyograghy of the facial muscle. The investigation was performed on the patients who received the parotid tumor surgery of the partial selective neurectomy for the facial spasms. The extratemporal facial nerve was carefully dissected until the fourth branching was identified. An electrical stimulation (the intensity: 2 volts, the duration: 0.1msec) was given first to the facial nerve trunk and then each discrete branch. Using bipolar needle electrodes the evoked EMG was recorded from the frontalis, orbicularis oculi, orbicularis oris and depressor labii inferioris muscles, respectively. The nerve fibers innervating the frontalis muscle existed only in the upper major branch, and the nerve fibers innervating the depressor labii inferioris muscle only in the lower major branch. The orbicularis oris muscle was innervated by both upper and lower branches. The orbicularis oculi muscle was innervated only by the upper branch in six patients, while in other five patients that was innervated by both upper and lower branches. The branches in the parotid gland innervated several facial muscles. These findings gave important bases on the repair of the extratemporal facial nerve in the parotid surgery.View full abstractDownload PDF (440K) -
YASUHARA HORIUCHI, YASUHIRO KASE, HIROAKI HUNAI, JUN YANO, TATUJIROU U ...1988 Volume 91 Issue 4 Pages 532-538,645
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIt is well known that the amount of bleeding of sinusectomy for chronic sinusitis is relatively large and differs much from case to case. The amount of bleeding during sinusectomy under local anesthesia was evaluated in 140 cases (251sides). Our routine sinusectomy consists of CaldwellLuc operation, transantral ethmoidectomy and endonasal surgery. The various factors influencing the amount of bleeding were investigated and the causes and definition for excessive bleeding were determined.
The averaged amount of the bleeding was 195g. The durations of sinusectomy, degrees of intranasal finding, pre-operative CT findings in regard to ventilation status, and morbid findings in the maxillary sinus were all related with statistical significance to the amount of bleeding. On the contrary, sex, height, body weight, blood pressure, the thickness of the anterior wall of the maxillary sinus and the area of the maxillary sinus in axial CT sections were not related to the amount of bleeding. The excessive bleeding was defined as the bleeding more than 400g on the basis of analysis of our operative records. The excessive bleeding was seen in 10% of all the cases. Causes for the excessive bleeding were determined retrospectively from the our operative records. Such surgical steps for the posterior aspect of the lateral nasal walls as ethmoidectomy and enlargement of the membranous portion were the common causes (37%) for the excessive bleeding.View full abstractDownload PDF (1090K) -
YOSHIHARU HIROTA, YAYOI SHIMIZU, TOSHITAKA IINUMA1988 Volume 91 Issue 4 Pages 539-546,645
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSTwenty cases of nasal bone fractures were evaluated as to the types of fractures based upon HRCT findings. Conventional X-Ray films for nasal bones were analyzed and compared with HRCT findings. Nasal bone fractures were classified into lateral and frontal fractures. HRCT images were evaluated in three planes including upper, middle and lower portions of the nasal bone. Fractures favored males of teens. Lateral fracture gave rise to the fractures of the nasal bone opposite to the external force, loosening of the ipsilateral nasomaxillary sutures and fractures of the frontal process of the maxilla.
Conventional X-Ray films were reevaluated after HRCT evaluation and indications of nasal bone fractures were determined. In addition to the discontinuity of the nasal dorsum, fracture lines parallel to and beneath the nasal dorsum and indistinct fracture lines along the nasomaxillary sutures are the indications of nasal bone fractures by conventional X-Ray films.View full abstractDownload PDF (3811K) -
YASUHIRO KASE, NOBUO KITAHARA, YASUHARU HORIUCHI, HIROAKI HUNAI, TATUJ ...1988 Volume 91 Issue 4 Pages 547-552,647
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe understanding of the CT artifact is important in diagnosing the various sinus lesions. We investigated several conditions causing thickening of maxillary sinus walls on CT. In unilateral sinusitis by conventional plane films of Waters-view the walls of the affected maxillary sinus showed a tendency (7/13 cases) to be thicker than those of non affected sides, suggesting the thickening is real, at least in part, and caused by inflammation. On the other hand, this tendency of sinus wall thickening in the affected sinuses is greater (12/13 cases) by CT. This indicates that CT artifacts may play a role in wall thickening. Specimens of anterior walls of the maxillary sinuses were obtained by sinusectomies in 14 sides. The actual thickness of the walls evaluated and compared with that of CT images. The thickness by CT was greater in all the 14 sides, confirming the CT artifact. This CT artifact was more influenced in sinuses of sinusitis than in normal sinuses. CT number of soft tissues in the maxillary sinuses showed a tendency to correlate with the apparent thickess of the anterior wall on CT. Phantom studies are in progress to more clarify this CT artifact.View full abstractDownload PDF (3790K) -
JUN KAWAKUBO, KAZUAKI OKIKURA, YOSHIKO AIKA1988 Volume 91 Issue 4 Pages 553-560,647
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSIn a through medical check up of engineering & construction and ordinary workers, 2702 and 110 people respectively, laryngeal fiberscopy was performed for 97 suspicious cases that were picked up by indirect laryngoscopy. Endoscopically guided biopsies were emploved to some of those cases.
Glottic abnormalities were found in 53 cases of 97 suspicious people, namely 1.9% of all examined.
Those 53 cases were 5 cases of laryngeal carcinoma (T1), 4 of either Keratosis, Papilloma or benign squamous hyperplasia, 12 of vocal cord polyp, 2 of vocal cord haematoma, 12 of chorditis, 7 of Reinke's edema and 3 of others. Each percentage was 0.18%, 0.14%, 0.43%, 0.07%, 0.43%, 0.25% & 0.11% respectively.
All but one of chorditis and Reinke's edema belong to engineering & construction group.
As for 1248 males over 50 year-old belonging to engineering & construction workers, the detection rate of laryngeal cancer was as high as 0.4% and about same rate reported in references of people with hoarseness.
Accordingly, the way of life in the engineering & construction workers, such as vocal abuse, smoking, drinking and so on, might be a cause of high detection rate of laryngeal cancer. This is why we should like to emphasize the necessity of medical check up, particularly laryngeal examination, for the engineering & construction workers.View full abstractDownload PDF (2643K) -
SUMIKO KOYAMA, JIN OKUBO, HIDEJI OKUNO, ISAMU WATANABE1988 Volume 91 Issue 4 Pages 561-569,647
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSPaget's disease of bone is an idiopathic disorder characterized by the excessive resorption and deposition of bone in a focal distribution. Although the disease is commonly diagnosed in western countries, it is rarely found in Japan. No description of Paget's disease affecting temporal bones with hearing loss, tinnitus, or vertigo has been available for reference in the Japanese literature up to 1987.
We reported a 48 year old man of Paget's disease complaining of progressive hearing loss in both ears and tinnitus of 7 years' duration. He gave no history of ear disease. Both ear canals were clean with no evidence of stenosis and the tympanic membrane was mobile, bilaterally. There was what appeared to be a Schwartze sign noted. His pure tone audiogram showed severe hearing loss of mixed type, for which he wore a hearing aid.
He was studied by Tomography (Front-Posterior projection) and CT scan (Horizontal section). Both petrous apices and margins of the internal auditory canals were demineralized and indistinct. The cochlea and semicircular canals were visualized; however their margins were indistinct. Skull X-ray examination revealed the presence of Cotton-Wool-Patch Appearance. On chemical analysis of blood and urine, serum AL-P and urinary OH-proline level were elevated. Such findings were consistent with Paget's disease. It has been reported that an increased blood flow through pagetic bone gives rise to a vascular shunt that could be one of the causes of sensorineural hearing loss. Furthermore, an elevated temperature in the area of pagetic bone due to an increased blood flow has been described.
In this paper, causes of conductive deafness, sensorineural hearing loss, and vestibular dysfunctions associated with this disease were discussed. Our study of oxygen tension of the middle ear space of this patient was presented. Measured by a PO2 sensor inserted into the tympanic cavity through the Eustachian tube, the partial oxygen pressure of the tympanic cavity was found to be 61 Torr in this patient with Paget's disease, whereas those of normal adults were 53.65±6.52 Torr (N: 10), suggesting an active gas transport mechanism in pagetic ears with its increased blood flow.View full abstractDownload PDF (4660K) -
ANALYSIS OF BIOPSIED MATERIALSKOUICHIROU TSUTSUMI1988 Volume 91 Issue 4 Pages 570-579,647
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
JOURNAL FREE ACCESSThe present study consists of 20 biopsy cases of supraglottic squamous cell carcinoma (SCC). Hematoxylin-eosin (H.E) stained specimens were first reviewed, and immunohistochemical and lectin histochemical stainings were done by the Avidin-Biotin Complex method using anti-basement membrane antibodies (Type IV collagen, Laminin), anti-Keratin antibodies (polyclonal, monoclonal) and lectins (PNA: Arachis hypogaea, UEA-I: Ulex europeus I). The data were analyzed in each group by the x2-test and multivariative statistical analysis (Quantification II). The results were as follows:
1. Keratinization (Patial Correlation Coefficiency: PCC; 0.53652) of the tumors and immunoreactivity of Type IV collagen (PCC; 0.46019) contributed greatly to the metastasis of regional lymph nodes (by the theory of Quantification II: Correlation ratio; 0.80808). In cases with moderately differentiated SCC and positive immunoreactivity of Type IV collagen, the metastasis to regional lymph nodes was rare.
2. Mitosis (PCC; 0.84277) of the tumor cells markedly contributed to the T-classification (by the theory of Quantification II: Correlation ratio; 0.79347). In cases of T1 & T2 group, mitosis was not frequent.
3. A significant correlation was found between the invasion of tumors and immunoreactivity of Type IV collagen and Laminin. In cases with mild invasion, immunoreactivity of Type IV collagen was positive (100%). In cases with marked invasion, immunoreactivity of Type IV collagen was negative (100%).
4. A significant correlation was observed between keratinization and reactivity of polyclonal Keratin and PNA lectin. In cases with moderately differentiated SCC, reactivity of PNA was positive (100%).
5. A significant correlation was noted between cellular atypism and reactivity of UEA-I lectin. In cases with low grade cellular atypism, positive tumor cells of UEA-I were present (75%).
From the above results, it was concluded that there was also a correlation between the morphological patterns of tumors stained by the H.E. method and the immunohistochemical and lectin histochemical observations. By means of combination of selected factors, supraglottic carcinomas could be clearly differentiated into two groups.View full abstractDownload PDF (2111K) -
1988 Volume 91 Issue 4 Pages 580-589
Published: April 20, 1988
Released on J-STAGE: December 22, 2010
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1988 Volume 91 Issue 4 Pages 589-600
Published: April 20, 1988
Released on J-STAGE: December 22, 2010
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1988 Volume 91 Issue 4 Pages 600-615
Published: April 20, 1988
Released on J-STAGE: December 22, 2010
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1988 Volume 91 Issue 4 Pages 615-628
Published: April 20, 1988
Released on J-STAGE: December 22, 2010
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[in Japanese]1988 Volume 91 Issue 4 Pages 630-633
Published: April 20, 1988
Released on J-STAGE: October 22, 2010
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