In the present study, we compare a new carbon dioxide (CO
2) absorbent, Yabashi lime
® with a conventional CO
2 absorbent, Sodasorb
® as a control CO
2 absorbent for Compound A (CA) and Carbon monoxide (CO) productions. Four dogs were anesthetized with sevoflurane. Each dog was anesthetized with four preparations, Yabashi lime
® with high or low-flow rate of oxygen and control CO
2 absorbent with high or low-flow rate. CA and CO concentrations in the anesthetic circuit, canister temperature and carbooxyhemoglobin (COHb) concentration in the blood were measured. Yabashi lime
® did not produce CA. Control CO
2 absorbent generated CA, and its concentration was significantly higher in low-flow rate than a high-flow rate. CO was generated only in low-flow rate groups, but there was no significance between Yabashi lime
® groups and control CO
2 absorbent groups. However, the CO concentration in the circuit could not be detected (≤5ppm), and no change was found in COHb level. Canister temperature was significantly higher in low-flow rate groups than high-flow rate groups. Furthermore, in low-flow rate groups, the lower layer of canister temperature in control CO
2 absorbent group was significantly higher than Yabashi lime
® group. CA and CO productions are thought to be related to the composition of CO
2 absorbent, flow rate and canister temperature. Though CO concentration is equal, it might be safer to use Yabashi lime
® with sevoflurane anesthesia in dogs than conventional CO
2 absorbent at the point of CA production.
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