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23 巻, 6 号
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大塚 嘉則1969 年 23 巻 6 号 p. 501-513
発行日: 1969/02/28
公開日: 2009/02/17
ジャーナル フリーThe present study was designed primarily in order to determine the effect of oral administration of Oil Yellow OB which had fed to rats at dietary levels of 0.75, and 0.5 per cent for three months and at 2.0, 1.0, 0.5, 0.25, and 0.1 per cent for two years. Single oral administrations was also done on mice.
Throughout the study the animals were weighed weekly and physical conditions observed. Autopsies were performed on animals which died as well as which were sacrificed. Tissues were fixed for histopathologic examinations.
Results were as follows:
1. In a single oral administration of Oil Yellow OB, the total mortality of the mice that were given the maximum doses of 3.8gm. per kilo. was 40 per cent. The LD50 value was not obtainable due to its insolubility.
Remarkable changes in liver were observed in all animals sacrificed after 10 days: the main changes observed were one or more of diffuse liver cell enlargement, excessive mitosis, and focal necrosis.
2. Rats which were fed Oil Yellow OB at 0.75 and 0.5 per cent of the diet had a marked weight loss. In the liver, irregular arrangement and enlargement of the liver cells, sometimes accompanying mitosis, were observed in the early stages, followed by massive necrosis and collapse in the later atage.
Thrombi were often observed in portal vessels.
3. In long term feeding studies, rats which were fed Oil Yellow OB in over 0.25 per cent of the diet showed high mortality, appetite loss and marked growth inhibition, whereas the dose of 0.1 per cent level produced no appreciable effect except slight growth retardstion. In the liver, marked changes were observed in doses of more than 0.25 per cent, while there were slight changes at 0.1 per cent. The main change was centrolobular necrosis which was followed by fibrosis and cirrhosis. Nodular hyperplasia of liver cells was sometimes observed, and atypical proliferation was present in one rat which was fed at a 0.25 per cent level and sacrificed at the 53rd week.Changes were also present in the heart and kidney in some cases.抄録全体を表示PDF形式でダウンロード (12501K) -
筋労働負荷による変動高桑 栄松, 大中 吉人, 斉藤 和雄, 安栄 鉄男, 井守 輝一, 小峰 妙子1969 年 23 巻 6 号 p. 514-518
発行日: 1969/02/28
公開日: 2009/02/17
ジャーナル フリーOur previous studies on the evaluation of mental stress by means of the TAF-test and experiments on TAF in relation to the brain waves indicated that the TAF may be a reasonable indicator of the state of central nervous activities. As to physical fatigue, the present studies have been carried out so as to know to what extent the change in TAF could be caused by muscular work.
By the use of ergometer, three kinds of muscular works (light-work for 300 minutes, heavy-work for 30 minutes and long middle-work for 120 minutes) were given to 22 healthy male students at three-day rest intervals.
Before and after the work load, the examinees were administered the TAF-test, brain-wave (α-wave) recording, knee-reflex and several other physiological function tests, and the expiratory gases were analyzed to measure the intensity of the load.
The results obtained were as follows:
1. Following the work-administration, the function of concentration maintenance (TAF-L) lowered in the heavy and long-middle works, while it increased in the light work.
2. The lowering in TAF after the work-administration significantly correlated with the volume of oxygen consumed in muscular work, that is, the greater the latter the greater the former.
3. In the extent over 650ml/min, of O2 consumption, the increase showed a significant correlation with that of the alpha-wave appearance in the brain waves.
4. The threshold value of knee-reflex significantly increased after the work-administration in all three kinds of physical loads using ergometer.抄録全体を表示PDF形式でダウンロード (555K) -
特に脂質代謝について河原林 忠男, 黒島 農汎, 中田 秀彦, 大野 都美恵, 速水 修, 猪熊 ミツエ1969 年 23 巻 6 号 p. 519-526
発行日: 1969/02/28
公開日: 2009/02/17
ジャーナル フリー最近肥満児に関する生理化学的および疫学的研究が数多く報告されているが,寒冷地における肥満児に関する系統的研家はほとんど行なわれていない。われわれは寒冷地肥満児の実態を明らかにする目的で旭川市の肥満児を対象に脂質代謝を中心に検討を行なった。
12才から14才の中学生男子で北海道に出生,旭川に居住している者から「青少年体力標準表」(水野,1968)により肥満児(22名)を抽出し,対照児(26名)とともに6月下旬から7月中旬にかけて早朝空腹時皮厚を測定,また採血を行ない血漿中の遊離脂肪酸(FFA),中性脂肪(TG),尿酸の測定を行なった。
肩甲骨下,上腕部,腹部皮厚は肥満児においては対照児に比して著しく大であった。
血中のFFAレベルは507±46.6μEq/Lit.で,対照児の549±56.4μEq/Lit.との間に有意の差がみられなかった。また尿酸も肥満児(7.0±0.36mg/dl)と対照児(6.3±0.27mg/dl)の間で差がみられなかった。
しかしながら肥満児においては皮厚と血中FFAレベルの間に相関の傾向がみられ,特にFFAレベルと肩甲骨下皮厚および(肩甲骨下皮厚+上腕部皮厚)/2の間には有意に正の相関がみられた。
血中TGのレベルは肥満児では104±14.1mg/dlと対照児の51±3.5mg/dlに比べて有意に高かった。
従来の報告は一様に小児肥満においては血中のFFA, TGレベルが高いと述べているが,われわれの結果ではFFAレベルは両群の間で全く差異が認められず,寒冷地における脂質代謝の特異性という点から興味ある知見と考えられ,今後さらに検討されるべきである。
血中の尿酸レベルは脂質代謝と密接な関係のあることが知られており,成人肥満では血中レベルの上昇が報告されているが,小児肥満では従来報告がなく,われわれの結果では両群の間に差を認めなかった。抄録全体を表示PDF形式でダウンロード (829K) -
変化騒音のTAF並びに体位変換による脳超音波減衰に及ぼす影響高桑 栄松, 井守 輝一, 斉藤 和雄, 高橋 正, 曽根 徳郎, 小峰 妙子1969 年 23 巻 6 号 p. 527-529
発行日: 1969/02/28
公開日: 2009/02/17
ジャーナル フリーThe present experimental studies were made to clarify the relationship between the changes of CUSA due to postural change and the lowering in TAF under exposure to variable noise as a stress stimulus. The variable noise used was composed of band noise and white noise smaller than 90 phon which randomly varied in cycle, decibel and duration.
Nine healthy male students were exposed to the unpleasant variable noise for two hours, and the TAF-test and the measurement of change of CUSA due to postural change were made both before and after the exposure.
The results obtained were as follows:
1) Exposure to variable noise caused a significant lowering in TAF-L in each examinee, as reported in our privious papers.
2) The changes of CUSA due to postural change after the exposure to variable noise increased significantly in comparison with the values before the exposure.
3) A significant correlation was observed between the lowering in TAF-L and the increase in the change of CUSA due to postural change, that is, the greater the lowering of TAF-L, the greater the incrcase of the change of CUSA.
These facts suggested that the mechanism of cerebral circulation in postural change may be put under the control of the autonomic nervous system in a stress state due to noise exposure, that is corresponding with the lowering of TAF.抄録全体を表示PDF形式でダウンロード (376K) -
高橋 透, 山下 節義, 西尾 雅七1969 年 23 巻 6 号 p. 530-538
発行日: 1969/02/28
公開日: 2009/02/17
ジャーナル フリーIn the period from April to July, 1967, 1234 rear-end collisions occurred in Kyoto Prefecture. Injuries and circumstances of 1053 drivers of the automobiles collided from behind were investigated with the questionaire method by mail, excluding death cases and motor-cycle accidents. Recovery rate was 74%.
The results were summarized as follows:
1. Rear-end collisions accounted for more than 20% of all vehicle-to-vehicle accidents in the period, and mostly occurred while the automobiles stopped at the intersections in the urban areas. Among the drivers investigated, 32% were professional drivers.
2. More than 68% of the drivers had physical complaints due to the accidents, symptoms and signs were various, some of them appeared even after the latent period.
3. A variety of diagnosis were given and treatments were also various, indicating the lack of the therapeutic principle.
4. Rests of patients indicated by physicians were frequently (up to 31%) interrupted by the early return of the patients to their social lives. The patients often could not afford sufficient hospitalization.
Importance of socio-economical factors lying behind the traffic accidents was discussed. Necessity of medical research institution for traffic accidents, public arbitration organization and social security system for the victims of traffic accidents were emphasized.抄録全体を表示PDF形式でダウンロード (1259K) -
梶原 三郎1969 年 23 巻 6 号 p. 539-543
発行日: 1969/02/28
公開日: 2009/02/17
ジャーナル フリーPDF形式でダウンロード (804K)
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