巻号一覧
37 巻, 4 号
選択された号の論文の7件中1～7を表示しています
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渡辺 正友1982 年 37 巻 4 号 p. 673-685
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーThe cytogenetic effects of aspirin and acetaminophen were studied on in vitro human lymphocytes. Cells were exposed to either aspirin (0, 75, 150 and 300μg/ml groups) or acetaminophen (0, 200, 400 and 600μg/ml groups) for the entire 72-hour culture period. Corresponding groups served as the controls.
It was found that the mitotic indices decreased as the aspirin and acetaminophen dosages increased. However, the occurrence of anomalies such as polyploidy or aneuploidy was not related to treatment with either drug. In contrast, when compared with the control groups, significant increases in chromatid and isochromatid gaps and breakages were noted for cells treated with both of the drugs. In the case of aspirin, the frequency of chromatid gaps was greater than that of isochromatid gaps, while in the case of acetaminophen, the frequency of the latter accounted for the greater proportion of chromosomal anomalies.
Neither changes in preferential sites for gaps or breakage, nor changes in satellite association frequency were observed in cells exposed to either drug.抄録全体を表示PDF形式でダウンロード (2973K) -
河野 俊一, 中川 秀昭, 栂 博久, 山本 三郎, 大村 外志隆1982 年 37 巻 4 号 p. 686-693
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーRespiratory function tests and arterial blood gas analyses were performed on 53 firebrick-makers exposed to diatomaceous earth dust and on 40 healthy farmers who served as the control group (group C).
The experimental subjects were ranging from 40 to 55 years of age. The brick-makers were subdivided into two groups based on chest X ray findings; group A of 22 brick-makers with pneumoconiosis and group B, 31 healthy brick-makers.
There were no significant differences among the three groups in the mean ages, heights, weights, indices of obesity or years as a smoker. There were no significant difference between groups A and B in the mean years of exposure to dust.
The following results were obtained:
1. The mean values of forced vital capacity/predictive vital capacity (% VC) and flow at 25% of forced vital capacity/height (V25/ht) of group A were significantly lower than those of group C, and those of foeced vital capacity (FVC), % VC, forced expiratory volume in 1 second (FEV1) and V25/ht of group B were significantly lower than those of group C.
2. There were no significant differences in the mean values of pH, PaO2 and AaDO2 between groups A and B, but there was in the case of PaCO2.
3. The relationships between AaDO2 and the obesity index, years as a smoker, V25/ht for group A and B were examined by, multiple regression analysis. Negative partial correlation coefficients were obtained for AaDO2 and V25/ht. Correlations between AaDO2 and the obesity index, years as a smoker were positive and significant.
Based on the results, it is reasonable to say that respiratory function tests are more sensitive than arterial blood gas analyses. It may also be concluded that the variables whitch caused an increase in AaDO2 were the obesity index, years as a smoker and V25/ht in brick-makers exposed to dust.抄録全体を表示PDF形式でダウンロード (988K) -
深瀬 治, 橋本 清澄1982 年 37 巻 4 号 p. 694-700
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーオゾン繰り返し暴露のマウス及びラット肺及びラット皮膚コラーゲンへの影響を検討した。0.2-1.7ppmオゾン5日暴露を行ったマウス肺では, オゾンの影響の指標として用いられる還元型グルタチオン量は濃度に比例して増加したが, コラーゲン量は変化しなかった。マウス肺コラーゲン量の有意の増加は1.0ppmオゾン40日の暴露で起り, 増加したコラーゲンは, 暴露終了後還元型グルタチオンより緩やかに減少した。マウス及びラット肺コラーゲンの大部分は0.5M塩化ナトリウム, 0.5M酢酸, 及び0.2Mシステアミン溶液に不溶で, その不溶解性は, ラットに1.0ppmオゾン10週まで暴露しても変らなかった。また, 1.0ppmオゾン10週暴露したラット皮膚コラーゲンは, その溶解性及び量に変化が見られなかった。抄録全体を表示PDF形式でダウンロード (846K) -
第7報 空中ブドウ球菌および人の身体の常在ブドウ球菌が産生する DNase 活性寺山 和幸, 平田 史子, 大野 秀樹, 河原 林忠男, 横田 正義, 青井 陽, 中田 秀彦1982 年 37 巻 4 号 p. 701-706
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーA quantitative analysis of the deoxyribonuclease (DNase) activity in airborne staphylococci dispersed by healthy volunteers and in resident staphylococci collected from them compared the production of coagulase. The results were as follows:
1. DNase activities in airborne coagulase-positive staphylococci (CPS) were almost the same as in a standard Staphylococcus aureus strain (FDA 209 P). In 84% of airborne coagulase-negative staphylococci (CNS), DNase activities were observed accounting, however, for less than 10% of those in CPS.
2. DNase activities in airborne CNS decreased markedly after 30min incubation at 100°C. This suggests that DNase in airborne CNS is different from the heat resistant DNase in Staphylococcus aureus.
3. The level of DNase activity in resident CNS was remarkably lower than in resident CPS. In 13 CNS strains isolated from the nose and skin, however, the values were similar to those of CPS. DNase in these staphylococci were heat-resistant. Thus, they may be mutants of Staphylococcus aureus which have lost the ability to produce coagulase.抄録全体を表示PDF形式でダウンロード (779K) -
蔵崎 正明, 伊藤 敬三, 斎藤 健, 斎藤 和雄1982 年 37 巻 4 号 p. 707-713
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーHuman erythrocyte catalase was assayed by the Sinha method (1972), which is simple and easy in comparison with the methods usually employed. The method was reproducible. However, using this assay method, the hemoglobin content in lysate samples should be adjusted to uniform concentrations. Nomral activity levels of erythrocyte catalase were determined for 122 normal healthy Japanese adults -69 males and 53 females. The mean±standard deviation was 7.90±1.33 (K(0)/gHb/dl), and the distribution was nearly normal. There was no significant difference with regard to sex. The results indicate that this assay can provide a source of important and basic data in clinical examinations.抄録全体を表示PDF形式でダウンロード (790K) -
鈴木 雅子, 青山 英康1982 年 37 巻 4 号 p. 714-721
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーRecently, it has been reported that the intake of fiber constituents can prevent chronic diseases including ishemic heart disease and diabetes. In this experiment, the inhibitory effects of fiber contained in rice bran were demonstrated when tar dyes were given to rats.
The results were as follows:
1) The fibrous contents of rice bran included 15.8% hemicellulose, 7.4% cellulose, and 4% lignin.
2) For 18 months, rats were fed a diet containing 5% of one of 11 the tar dyes or one containing 5% the dye and 5% of rice bran fiber. The survival rate at the end of the test was much greater for the latter group.
3) Comparisons of weight gains during the first 4 weeks following the start of the experiment revealed that the group given only the tar dye was markedly retarted in growth, while the group given both the fiber and the dye had normal growth.
4) Comparisons of tumor development during the test period disclosed abdominal lymphosarcoma in two rats among the dye only group. Both rats survived until the end of the test, but no tumor development at all was observed in the dye + fiber group.抄録全体を表示PDF形式でダウンロード (882K) -
今井 正之, 吉田 克己, 冨田 泰子, 笠間 一男, 北畠 正義1982 年 37 巻 4 号 p. 722-728
発行日: 1982/10/30
公開日: 2009/02/17
ジャーナル フリーThe prevalence of respiratory diseases, and bronchial asthma in particular has increased in Yokkaichi with the worsening in air pollution during the period of 1961 to 1962.
A Public Relief System was established in 1965 in order to assist sufferers.
It was revised in 1973 based on laws to deal with Compensation for Victims of Environmental Pollution.
The fiscal year 1980 was the year in which pollution victims were to be re-examined.
The results of medical examinations of 488 bronchial asthma victims in the Yokkaichi area were examined and the following results were obtained:
1) The onset of asthma coincided with periods when there was marked air pollution in Yokkaichi.
2) Asthma due to allergic reactions was found in most younger victims age group (under 39 years old) and infectious asthma in many older victims (over 40 years old).
3) Asthma caused by environmental pollution is characteristic of advanced age and is often complicated by clinical symptoms such as chronic cough and the discharge of sputum.
A low percentage have eosinophilia and low show positive intradermal reactions to house dust.
4) According to auscultation and lung function tests, symptoms appeared to be reversible in many of younger cases, but attacks were repeated or symptoms indicated permanent damage in most of the advanced age group.抄録全体を表示PDF形式でダウンロード (933K)
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