巻号一覧
41 巻, 4 号
選択された号の論文の8件中1～8を表示しています
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平井 幸雄, 長谷川 亨, 友国 勝麿1986 年 41 巻 4 号 p. 723-731
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリーGroundwater around Saga city was characterized by determining anionic surfactants, trichloroethylene, tetrachloroethylene, silicic acid, phosphates, nitrite and nitrate, ammonia, sodium, magnesium, calcium, and iron in thirty nine samples of well water.
The remarkable increase in concentrations of both sodium and magnesium from the northern to the southern areas of Saga city suggested the permeation of sea water from Ariake sea located in the south of Saga city. Correspondingly, there was also a remarkable increase in concentrations of inorganic nutrients such as phosphates and ammonia. Nitrite and nitrate concentrations were low, and ammonia and iron concentrations were relatively high in well waters in the southern part of Saga city. This fact indicated that the groundwater in this area existed in a highly anaerobic condition. Concentration of anionic surfactants was generally low. However some well water showed possible contamination of anionic surfactants. Neither trichloroethylene nor tetrachloroethylene was detected.抄録全体を表示PDF形式でダウンロード (1159K) -
豊嶋 英明, 橋本 修二, 岡本 和士, 前田 清, 柳生 聖子, 加藤 孝之, 木沢 仙次, 佐野 正樹, 大脇 淳子1986 年 41 巻 4 号 p. 732-740
発行日: 1986/10/31
公開日: 2009/03/31
ジャーナル フリーTo investigate the effects of daily ingested nutrients on serum levels of HDL constituents, amounts of daily food intake for three consecutive days were measured and serum levels of HDL-cholesterol and apolipoproteins A-I (abbreviated as apo A-I) and A-II (abbreviated as apo A-II) were determined for 48 subjects living in a local community.
Mean HDL cholesterol level was significantly lower in type IIB (46.8±8.3mg/dl, p<0.05) and IV (40.9±9.9mg/dl, p<0.001) hyperlipoproteinemics, accompanied with hypertriglyceridemia, than in normolipoproteinemics (56.4±8.8mg/dl). However, the apo A-I levels were the same as normal (146.8±14.7mg/dl) and apo A-II levels, higher in types IIA and IV than in normal. These findings suggest a different response of lipid and protein parts of HDL to ingested carbohydrates.
HDL cholesterol had a significant negative correlation to the amount of carbohydrate (r=-0.29, p<0.1) and protein (r=-0.34, p<0.05) daily ingested. Apo A-I and apo A-II had a significant negative correlation with carbohydrates (r=-0.51, p<0.01 and r=-0.31, p<0.1, respectively). However, when the intake of nutrients were expressed with the adequacy rate (amount ingested/amount recommended), which were adjusted for differences in individual sex, age, bodily constitution, and work load, HDL cholesterol lost the significant negative correlation with carbohydrate while apo A-I and apo A-II still retained or increased it.
Excessive intake of carbohydrates has been known to accelerate the catabolism of HDL. In our study, it was shown that the increase of daily carbohydrate intake within a normal range mainly decreased the serum apo A-I and A-II levels. Considering the function of HDL in removing cholesterol from peripheral tissues, it was suggested that the intake of carbohydrates might have important effects on the genesis and prevention of atherosclerotic diseases by affecting the constitution of HDL.抄録全体を表示PDF形式でダウンロード (1079K) -
木下 修三, 垣平 博臣, 大谷 由美子, 由井 宏道1986 年 41 巻 4 号 p. 741-745
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリーThe effects of sodium nitrite (NaNO2) were tested on strips of the cardiac muscle prepared from the ventricles of male ICR mice 4, 16 and 78 week-old. The strips were immersed in Ringer solution containing 0.01% NaNO2 and action potentials evoked by repetitive electrical stimulation were recorded by means of conventional microelectrode recording. The results obtained were as follows.
1) In 4 week-old mice: No detectable difference was observed in the action potential responses evoked by 5Hz stimulation at 1.3V in the control (before treatment), treatment (with NaNO2) and recovery periods. At 10Hz, action potentials were evoked once every 2 stimuli in the control and once every stimuli in the treatment. At 20Hz, action potentials were evoked every 3rd stimulus in the control and once every 2nd stimulus in the treatment. The responses thus elevated did not return to the control level during the periods of recovery after wash out of the drug.
2) In 16 week-old mice: The responses were tested at 1.0V and found similar to that of the 4 week-old animals. However, they recovered appreciably during the wash out period.
3) In 78 week-old mice: Action potentials were normally evoked by 1.5V stimuli at 5Hz in the same way as 1) and 2), whereas 2.8V were needed at 10 and 20Hz in the treatment with the drug. The responses was elevated in the treatment, as in 1) and 2), and somewhat reduced in the wash out period.抄録全体を表示PDF形式でダウンロード (625K) -
染谷 孝, 茅原 四郎, 田辺 忠夫1986 年 41 巻 4 号 p. 746-751
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリーOne hundred and forty-six strains of staphylococci were isolated from three exposed skin parts on the arm, forehead and crown of the head of 42 female junior college students. Isolated staphylococci were identified as the following ten species; S. aureus, S. simulans, S. xylosus, S. cohnii, S. haemolyticus, S. saprophyticus, S. warneri, S. hominis, S. capitis, S. epidermidis and unideitified staphylococci. Ninety-six percent of the isolated strains were coagulase negative staphylococci which were subdivided into 85% of S. epidermidis species group, 6% of S. saprophyticus species group and 3% of S. simulans as indicated by Kloos with the nuclear DNA homology of Staphylococcus species.
The sensitivity tests were carried out to isolated skin staphylococci with five antibacterial agents. PCG resistant staphylococci were 46 (32%) of 146 strains, but high PCG resistant strains were not isolated. Staphylococci resistant to four other agents, KM, DOXY, EM, and CP were 4 (2.7%), 12 (8.2%), 11 (7.5%), and 6 (4.1%) strains respectively, and 9 of the EM resistances and 2 of the CP resistances were high resistant strains of MIC≥100μg/ml.
The same staphylococci of 146 strains were reinvestigated with a distribution of drug resistance in the above ten species. Comparisons were attempted with three divided groups of staphylococcal species; 62 strains of S. epidermidis, 38 strains of S. capitis and 46 strains of the remaining eight species. PCG resistant strains were recognized in 44% of the S. epidermidis and 37% of the eight species, but PCG resistant S. capitis was only recognized in 5% of the tested strains, corresponding to 1/4-1/5 of the distribution ratios of the other two groups. Though KM resistant strains distributed in an equal ratio to each of the three groups, DOXY, EM, and CP resistant strains of S. epidermidis and S. capitis were only 1/3, 1/7 and 1/3 of the distribution ratios of eight species. These results suggest that drug resistances are not evenly acquired and transferred among the species of skin Staphylococcus.抄録全体を表示PDF形式でダウンロード (785K) -
性・年齢別の解析村田 勝敬, 荒記 俊一, 横山 和仁1986 年 41 巻 4 号 p. 752-763
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリー悪性新生物死亡に及ぼす性・年齢別の地域生態学的因子の影響を明らかにするために46都道府県(日本)の社会生活統計指標(20指標)を説明変数とし,悪性新生物(胃,肺,乳房,子宮,白血病および全悪性新生物)死亡率を目的変数とする重回帰分析(逐次変数選択法)を5年間隔で2回実施した。これらの説明変数は以前の我々の解析(因子分析)により8群の基本的な地域生態学的因子に分類されていた。
以下の4因子が2年次とも特定の性・年齢群の悪性新生物死亡率(カッコ内)に有意な影響を与えたリスクファクターとして抽出された。1)都市居住(高年女子の胃,肺,乳房および子宮の悪性新生物と高年男女および中年女子の全悪性新生物)。2)地方居住(中年男子の白血病と全悪性新生物および女子学童の白血病)。3)低所得(中高年女子の子宮,中年女子および高年男子の肺,および高年男子の全悪性新生物)。4)高齢人口(中年男子の胃悪性新生物,女子乳幼児の白血病,および若年および高年男子の全悪性新生物)。
性・年齢別の全悪性新生物死亡率は,肺悪性新生物および白血病と共に,高年男子で5年間に有意な上昇を示した。46都道府県内の市部における肺,乳房,子宮および全悪性新生物の訂正死亡率は郡部と比べ2年次とも有意に高かった。抄録全体を表示PDF形式でダウンロード (1177K) -
平池 秀和, 木村 美恵子, 糸川 嘉則1986 年 41 巻 4 号 p. 764-768
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリーEndogenous K vitamins (VKs) in human placentae were detected and identified by high-performance liquid chromatography (HPLC) with fluorometric detection using post-column reduction. Phylloquinone (K1) and menaquinones (K2: MK-4, 6, 7) were found in human placentae.
The recovery rates of this assay were assessed by adding known amounts of VKs to the sample. Between 60% and 65% of added K1 and MK-4, 6, 7 were recoverd from the placentae by this assay method.
The mean placenta concentration of K1 in 13 normal placenta with normal diet was 1.22ng/g (range: 0.55-2.29), MK-4 was 1.14ng/g (range: 0.38-2.04), MK-6 was 0.13ng/g (range: not detected-0.61), MK-7 was 1.04ng/g (range: 0.36-2.55). These data were corrected by recovery rates. The detection limits of K1 and MK-4 in placentae were 0.1ng/g, and those of MK-6 and MK-7 were 0.2ng/g.
Two pregnant women ate fermented soybeans (NATTO) on alternate days for one month before delivery. Their placentae contained a high density of MK-7 (6.69 and 14.95ng/g), because MK-7 is abundant in fermented soybeans.
These results may be helpful to elucidate the cause of a neonatal hemorrhagic disease occuring two or three days after birth which appears to be at least in part responsive to vitamin K therapy.抄録全体を表示PDF形式でダウンロード (571K) -
村上 憲司, 西山 敬太郎, 樋口 富彦1986 年 41 巻 4 号 p. 769-774
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリーラットに5%フタル酸ジブチル(DBP)含有粉末飼料を35∼45日間与えた結果,成長抑制,肝肥大,精巣萎縮が認められた。又,同時に肝ミトコンドリアの呼吸抑制が認められた。この呼吸抑制はコハク酸およびピルビン酸脱水素酵素の活性低下によるものであった。
このようなDBPのミトコンドリアに及ぼす影響はin vitroでも確認された。即ちin vivoで観察された呼吸活性の低下と同程度の低下はDBP100μM以下の濃度で認められ,又同様にコハク酸脱水素酵素活性の低下は150μMで認められた。
又,亜ミトコンドリア粒子を用いた実験結果から,DBPは容易にミトコンドリア内に入り,コハク酸の膜透過には変化を与えず,コハク酸脱水素酵素活性に直接作用することが示された。抄録全体を表示PDF形式でダウンロード (721K) -
村上 憲司, 西山 敬太郎, 樋口 富彦1986 年 41 巻 4 号 p. 775-781
発行日: 1986/10/31
公開日: 2009/02/17
ジャーナル フリーラットにフタル酸ジブチル(DBP),フタル酸モノブチル(MBP),フタル酸(PA)およびフタル酸ジ-2-エチルヘキシル(DEHP)の各々0.5%又は5%含有粉末飼料を34∼36日間与え,各化合物の毒性比較を行った。
DBP,MBPおよびDEHPの5%投与群では,成長抑制,肝肥大,精巣萎縮,肝ミトコンドリアのコハク酸およびピルビン酸脱水素酵素活性低下,血清生化学検査における異常所見,肝および精巣の組織変化がみられた。このような変化の一部は0.5%投与群にも軽度ながら認められた。しかしPAは5%投与群でも何らの変化もみられなかった。
肝細胞の電顕所見においてはMBPよりもDBP投与による影響の方が著しかった。又,in vitroにおいて,DBPは正常ミトコンドリアのコハク酸脱水素酵素活性を著しく低下させたが,MBPにはそのような作用が認められなかった。呼吸活性に対しても両化合物間に同様の相違がみられた。
以上の成績はDBPの経口毒性が代謝産物であるMBPおよびその後続酸化物によるものの他に,少なくとも肝に対しては,未代謝のDBP自体による影響も存在することを示している。抄録全体を表示PDF形式でダウンロード (698K)
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