After oral or intravenous administration of ¹⁴C-dibutyl phthalate into male mice, radioactivity was found to be rapidly distributed in the organs and tissues by whole body autoradiography. In particular, a high level of radioactivity was found in the liver and kidneys within the first hour after intravenous injection of ¹⁴C-DBP and rapidly decreased thereafter. In these male mice, the urine and feces level of radioactivity after intravenous injection of ¹⁴C-DBP reached a peak at 30min and 1hr, respectively, and then declined rapidly. However, the feces level of radioactivity after oral administration of ¹⁴C-DBP reached a peak at 6hr and then decreased gradually.
From the above results, it was suggested that orally or intravenously administered ¹⁴C-DBP into male mice was readily absorbed from the gastrointestinal tract and rapidly excreted in the urine and feces.

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新潟県新発田市A地区(農山村,積雪地帯)に在住する婦人を対象として,血色素量を測定したところ,12g/dl未満の低血色素量を示す者が24.4%も認められた。この率は,WHOの勧告値5%をはるかに上回るものであった。ここに,A地区婦人における貧血の予防と改善のための公衆衛生活動が積極的に行なわれるべきであるというニードが生まれた。
貧血の発生要因を病態生理学的な立場から検討してみると,鉄欠乏性貧血であることが示唆された。
次に,貧血発生の社会医学的要因を横断研究(多変量解析法を含む)と縦断研究とから検討してみると,肥満度,鉄の摂取量,労働強度,家族構成,収入,妊娠回数の6要因がA地区婦人における貧血の発生に大きい影響をおよぼしていることが解った。
以上の結果から,A地区婦人の貧血発生は,女性特有の生理的現象を背景として,農家の兼業化促進のしわよせによる労働過重と,それによる人体の栄養の需要と消耗に対して,十分な栄養補給がおよばないことによると考えられ,栄養摂取状態の改善,農村婦人の労働改善,適切なる家族計画の指導を骨子とした公衆衛生活動を,市役所保健課,保健所,医師会,県立病院,A地区住民組織が一体となって実施した。
1970年におけるA地区婦人の貧血(全血比重1.050未満,血色素量12g/dl未満,ヘマトクリット値36%未満のいずれかに該当する者を貧血と判定した)の有病率は30∼40%であったが,1974年には20∼30%に減少した。これは貧血の予防と改善のための公衆衛生活動の効果であると評価された。

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亜硫酸エアゾールを吸入した際の反応としてのマウスの呼吸数の変化を研究し,亜硫酸ガスの場合と比較した。重亜硫酸ソーダ又は重亜硫酸カリウムのエアゾールへの曝露に際しては,その反応パターンは亜硫酸ガスの反応パターンと極めて類似していた。重亜硫酸ソーダと重亜硫酸カリウムとの間には,呼吸数の最大減少度で測った刺激性について差がなかった。これに対して,亜硫酸ソーダ又は亜硫酸カリウムは,単に無作用であるばかりでなく,亜硫酸ガスの刺激性にも影響をあたえることはなかった。ある濃度の亜硫酸ガスによってその刺激に対する感受性を失ったマウスは,同じ濃度の重亜硫酸ソーダに対してはもはや反応を示さなかった。
亜硫酸ガス及びその塩類の刺激性は,鼻腔粘膜において生じた重亜硫酸イオンの還元性によるものであり,共存する陽イオンには関係がないと結論することができる。

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塩化メチル水銀の免疫能に及ぼす影響をdd系雄性マウス(体重20±2g)を使用して観察した。1群10匹のマウスに種々の濃度の塩化メチル水銀を1回または数回経口投与し,羊血球を抗原としてメチル水銀投与との時期的関係を考慮しながら免疫した。免疫後経時的に採血し,又摘脾を行ない,血清の血球凝集素価,溶血素価を,脾臓中の抗体産生細胞数を各々測定して次のような結果を得た。
1. 比較的低濃度の塩化メチル水銀を急性あるいは亜急性に投与されたマウスの抗体産生能にはほとんど変化が見出されなかった。
2. しかし比較的多量で体重減少や神経症状が発現する直前のメチル水銀濃度でマウスの抗体産生能が影響されることが判明した。
3. その場合,メチル水銀投与と抗原刺激の時期的関係によりメチル水銀が抗体産生に促進的に働いたり,逆に抑制的に作用したりする傾向があることがわかった。すなわち,抗原刺激前にメチル水銀が投与されると免疫反応の初期に抑制がみられ,抗原刺激後にメチル水銀が投与されると免疫反応の中期から後期にかけて促進がみられた。
4. メチル水銀は血清中のγ-グロブリンに直接作用する可能性は少なく,むしろ脾細胞中での免疫応答過程に作用するものと思われる。なおcAMPを介しての作用の可能性について考察した。

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The increase of urinary δ-aminolevulinic acid in lead poisoning is well observed. In this paper, the effects of lead acetate on the activities of Δ⁴-reductase and 5β-reductase to cortisol, cortisone, testosterone and Δ⁴-androstene-3, 17-dione and of dehydrogenase to 3α-hydroxysteroid and 3β-hydroxysteroid were examined. To measure the activities, 12, 000×g and 105, 000×g supernatant of rat liver were used.
The Δ⁴-reductase activity to cortisol and testosterone showed a significant decrease twenty-four hours after the administration of lead acetate, but that to testosterone showed a remarkable increase seventy-two hours after the administration of lead acetate.
The 5β-reductase activity to testosterone decreased significantly twenty-four hours after the administration of lead acetate, but increased seventy-two hours after administration of lead acetate. No significant difference was found in Δ⁴-androstene-3, 17-dione.
From these results, it was suggested that steroid 5β-reductase activity was an important factor in affecting the heme synthesis in lead poisoning.

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By the clinico-epidemiological approach considering sex and age, ABO blood group and cancer family history data have been examined for 1779 patients with stomach cancer. The results obtained are as follows:
In the group of stomach cancer patients with two or more cancer families among their parents and sibs, the percentage of the patients of blood group A is significantly higher than the percentage in the group of control people.
When sex and age differences about the former are considered, the rate of blood group A is more prevalent in young male than in young female patients under 50 years old, but more prevalent in old female than in old male patients 50 and over.
In the group of young male stomach cancer patients under 50 with one stomach cancer family, the percentage of the patients of blood group A is significantly higher than the finding of the control.
These findings also are understood from the analyses of sex ratio considering the age group differences.
In the group of young stomach cancer patients with two or more cancer families even in no relation to blood groups, the sex ratio is significantly high in comparison with the sex ratio of all the young patients' group.
Concerning to the clinical pictures such as original sites in the stomach and histological patterns, there are no noticeable differences between the stomach cancer patients of blood group A with two or more cancer families and all the stomach cancer patients. But when the age difference is considered, the rate of pyloric antrum cancer is more prevalent in the old patients of the former, and by the morphological examination, it is found that there are some multiple polyposis cancers on the pyloric antrum.
Then seeking out the multiple polyposis cancers on the pyloric gland area about 512 cases of early stomach cancers and relatively early stomach cancers whose cancer infiltrations are confined within the submucosa layer, we have found 12 cases of multiple polyposis cancers. Nine cases out of 12 cases are old patients of blood group A, of which, 7 cases are patients with cancer family history.
When comparing the original organs of cancer regarding the family cancer patients between the group of stomach cancer patients with one cancer family and the group of stomach cancer patients with two or more cancer families, the rate of the organ cancers, i.e. stomach, uterus, liver and biliary passages, is significantly higher in the latter than in the former.
In both groups of the double cancer patients together with stomach cancer and other organ cancer, and the multiple stomach cancer patients (though being restricted to the early stomach cancer cases), both percentages of the patients of blood group A are relatively high as compared to the percentage of the control.

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In Japan a nationwide survey of school children's physical growth has been carried out by the Ministry of Education every year since 1900 except the years of World War II. An attempt was made to elucidate the growth acceleration in height by making use of the statistical date of the above-mentioned survey. The maximum growth age (MGA) in height was taken as an indicator of the growth acceleration. The results were as follows:
1. MGA in height was found to be gradually going down since before the war. The growth acceleration in the prewar years was found to fit a straight line. In the postwar years, the growth acceleration of boys born in the 1950's proceeded along the regression line based on the prewar acceleration rate.
2. Lowering of MGA in height of boys and girls born after the war was found to fit Gompertz and logistic curves. The postwar growth acceleration with its point of reference at the end of the war was remarkable: MGA in height went down by 2.0 years for boys and 1.5 years for girls in 25 years. This period, however, should be regarded as a convalescent stage after the repression of growth due to the war.
3. If the postwar growth acceleration was to be taken as a part of the whole phenomenon in gradual progress since before the war, as it actually was, the rate of acceleration for boys was 0.2 year per 10 years.
4. In the case of girls, the growth acceleration in the prewar years was slower than that of boys, and the progress in the postwar years surpassed the regression line based on the prewar rate. The prewar slower rate for girls as compared to boys can be attributed to a situation peculiar to Japanese social background. In the prewar days, girls' place was lower than boys' in both social and home life and this fact may have affected repressively on the physical growth of girls.
5. The growth acceleration is likely to proceed for some time to come but a prediction on the phenomenon must wait for further investigation.

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