Studies on experimental asthma have been carried out by various methods. The author used a modified Friebel's device, in which guinea pigs were kept and could breathe in natural posture.
Dyspnea was produced by inhalation of nebulized Histamine, Acetylcholine, and Serotonine solutions or Horse-scrum.
Degree of dyspnea was estimated dirided into 5 grades by respiration curves.
Adequate drugs and their optimal concentrations to produce moderate dyspnea suitable for the experiment were investigated and determined, namely 0.5-1.0mg/ml of Histamine or 2.0mg/ml of Acetylcholine was inhaled for 3-5 minuter (0.1-0.3ml) in summer, 1.0-1.5mg/ml and 2.5-3.0mg/ml respectively in winter.
Investigations were preformed not only with bronchial response but also with skin reaction. There were no significant correlation between them.
The author proved that animals sensitized with .Horse-serum manifested an increased sensitivity both in Histamine skin test and Acetylcholine inhalation test.
It was found also that serial daily cold baths (20°C) lowered Histamine sensitivity in a week, but little change was noted by warm baths (40°C).
After 2 weeks the sensitivity was elevated in both cases and in 3-4 weeks it was decreased.
Acetylcholine sensitivity decreased in 2 weeks in warm harm bath group.
Both bronchial and cutaneous sensitivity to Histamine and Acetylcholine fell in winter (December, January and February) and rose in summer (June, July and August).
Therefore bronchial and cutaneous sensitivity to Histamine and Acetylcholine, chemical mediators of allergic reaction, changer various postnatal conditions.

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1) An objective method which included the determination of muscle strength, range of passive joint motion, and also activities of daily living, was used to evaluate physical abilities and disabilities of hemiplegic patients along the course of rehabilitation. The data obtained by this method was statically analysed. 92 patients, who had suffered from a cerebrovascular accident more than 3 months previously, were examined and treated on one month rehabilitation course with balneotherapy.
The results were promissing in spite of the short duration of the treatment.
Group A (patients with duration of hemipiegia for 3-6 months after the cerebrovascular accident) showed 78.6% of the normal A. D. L. at the end of the treatment while the control group showed only 64.4% of normal.
Group A showed a gain of 48.7% in the improvement of A. D. L., group B (duration of hemiplegia for 6-12 months after onset) 40.8%, and group C (over 1 year after the cerebrovascular accident) only 31.6%.
The relationship between the improvement in A. D. L. and the time intervall between the start of the treatment and the onset of the cerebrovascular accident proved statically significant, namely, the earlier was the start of the rehabilitation, the better was the clinical improvement.
The improvement in muscle strength was not so marked as in A. D. L.
The ralationships between improvement in A. D. L., in muscle strength and in the range of passive joint motion all proved statistically significant.
Patients who were under 59 years of age gained significantly more improvement in A. D. L. and muscle strength than the patients who were over 60 years of age. It seems to the authors that this derives from a diminished will of the patient to recover and a decrease in the amount of exercise in the older aged group.
Concerning the range of passive joint motion, group A showed improvement of 47.1%, group B 46.1%, and group C 35.2%. Regarding these remarkable improvements, there was no difference between the older age group and the younger age group. It seems to the authors that the improvement of the range of passive motion of joints derives from the relief from the pain by spa treatment, which resulted from contracture and other pathologic changes around the joints.
The authors conclude that, along with some favorable effects of balneotherapy on the basic disorders of the cerebrovascular accident, an utility of balneotherapy in the rehabilitation of hemiplegic patients lies in this improvement in the range of passive motion of joints as mentioned above which must have favorable effect on active exercise.
2) Improvement in A. D. L. of 21 stroke patients (cerebral hemorrhage -7 cases; thrombosis -8 cases; unclassified -6 cases.) to whom passive exercise of the affected site of extremities was introduced shortly after a stroke, was examined similarly as mentioned above.
In the cases of cerebral thrombosis, passive movement was begun 2 hours after the stroke, and in the cases of cerebral hemorrhage or unclassified cause, 2-3 days thereafter.
Among 6 fatal cases, 5 died within a week after the stroke when the passive movement was not yet introduced.
Among 15 survived patients, 11 cases (73%) got over 75% of normal A. D. L., and only 2 cases (13.3%) remained under 25%.
No case of the second attack was seen through the course of rehabilitation.
3) The repeatedly evoked E. M. G. was studied before and after a thermal bath of Kageyu (simple thermal spring), and plateau level changes were compared with impovement in A. D. L., M. S., and R. P. J. M.
Plateau level changes by thermal bath are considered to be determined by α and γ system conditions, and the improvements of A. D. L. by the spa treatment could not be interpreted by the E. M. G. changes.

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It is a well-known fact that the death rate from cerebrovascular accident has been highest in Japan since 1951. About 160, 000 persons died of cerebrovascular accident during the year 1962 in Japan. The mortality of cerebrovascular stroke being about 50%, it follows that the number of hemiplegic patients will increase by 160, 000 every year. Recently people are much concerned over the rehabilitation of hemiplegic patients and that is why we are making a report on the results obtained from physical therapy such as hot-spring bathing, therapeutic exercise, etc.
Cerebral hemorrhage, thrombosis and embolism are considered to be causative of hemiplegia, 34 cases resulting from cerebral hemorrhage, and 64 cases from cerebral infarction, the latter being much larger than the former in number, The duration from the stroke to admission for rehabilitation was less than a month in 9 cases (9.2%), 1 to 3 months in 27 cases (27.6%), 3 to 6 months in 31 cases (31.6%) and so within 6 months in 67 cases (68.4%). According to our method for evaluation, the ability of movement of the patients at the time of admission was more than 5 in their lower extremities, that is, they could manage to ambulate, but slow of recovery in their upper extremities.
Nine cases of hemiplegia who had not bathed since cerebrovascular stroke were made to bathe by the electric hoist apparatus at 37° to 38°C for 10 minutes, Of 9 cases, 6 showed a slight rise of blood pressure immediately after bathing, but all nine cases showed a fall in blood pressure below the pre-bathing value after 90 minutes. Of these cases, the one who was made to bathe at the earliest date from stroke did so 24 days after the stroke. It seems that there are no risk in making a patient bathe at an early date from the stroke.
Observation was made of the effects of luke-warm bath, electric bath, massage and active exercise of the upper limbs on blood pressure and plecysmogram. It was found that blood pressure fell after luke-warm and electric bathing, but that it slightly rose after massage and active exercise. As to the effects on the plecysmogram, it may be said that all four mentioned above will act effectively on blood circulation, among which the electric bath is most effective.
The effect of rehabilitation was most remarkable in 19 cases, remarkable in 27 cases, slight in 32 cases, invariant in 18 cases, death in 2 cases, showing effectiveness in 46 cases, 47.2%. Invariant cases included those who had been admitted after they had recovered their movement almost completely. The recovery was better in the cerebral hemorrhage than in cerebral infarction and the recovery was better in the lower limds than in the upper limbs, The larger of cases in which rehabilitation was most effective and remarkable were those in whom the rehabilitation was instituted soon after the stroke, but there were cases in whom the rehabilitation proved effective even though the program was instituted over a year after the stroke, which is suggestive of the importance of rehabilitation. No definite relation seems to be present between the age of patients and the effect of rehabilitation, nor there seems to be any definite relation present between serum cholesterol and such laboratory findings as the function of kidney and the eyeground. The electromyograms taken before and after rehabilitation showed that there were signs of improvement in all cases, though different in all cases, though different in degree. It can be verified from the electromyograms the improvement was better in the lower limbs than in the upper limbs.
The replies to the inquiries on prognosis sent to 104 patients who were discharged from this hospital and the National Narugo Hospital from 1955 to 1962 were received from 79 persons, Compared with the condition at the time of discharge, 32 cases showed some improvement, 20 cases slight improvement, 17 cases invariant, 5 cases recurrence and 5 cases of death. Of the five cases of

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