気管支喘息32例を対象に, ヨードゾル吸入療法を行い, その効果について換気機能および臨床症状の面から比較検討した。
1. ヨードゾル吸入30分後の換気機能の検討では, いずれの換気パラメータ値も吸入前値に比べ増加の傾向を示し, この傾向は, %V₅₀および%V₂₅においてより高度であった。しかし, いずれの換気パラメータ値の増加においても, 吸入前値に比べ有意の差は見られなかった。
2. 朝, 夕, 2回, 2週間のヨードゾル吸入療法により全ての換気パラメータ値の増加が観察された。この増加は, 特に%MMF, %V₅₀及び%V₂₅においてより高度であり, %V₅₀では吸入前値に比べ有意の増加を示した (p<0.05)。
これらの換気パラメータ値の改善は, ヨードゾル吸入療法が小ないし細気管支領域の狭窄ないし閉塞に対してより有効であることを示している。
3. ヨードゾル吸入療法の臨床効果は, 32例中24例 (75.0%) で観察された。

抄録全体を表示

温泉療法の臨床効果は, 個々の温泉療法の臨床効果と, それらの組み合わせ及び周囲の環境因子の影響を含めた, 総合的な温泉療法の臨床効果に分けられる。当院へ入院し, 1-3か月間の温泉療法を受けた重症難治性気管支喘息36例を対象に温泉プール水泳訓練, ヨードゾル吸入療法および鉱泥湿布療法などの個々の温泉療法と, またそれらを組み合わせた総合的温泉療法の換気機能に及ぼす影響について検討した。
個々の温泉療法の換気機能に及ぼす影響を比較してみると, 一回の温泉療法での改善率は, 全般的には鉱泥湿布療法が最も良く, 次いでヨードゾル吸入療法, 温泉プール水泳訓練の順であることが明らかにされた。
総合的温泉療法によって各換気パラメーターとも治療開始1か月目で明らかな増加傾向を示したが, 2か月目にはややその増加傾向は鈍り, むしろ治療開始3か月目に最も著明な増加が観察された。また, その増加率は, V₂₅で最も高く, ついでV₅₀, MMFの順であり, 小ないしは細気管支領域の換気障害を示す換気パラメーターの改善がより高度であることが示唆された。

抄録全体を表示

Although acupuncture is considered to have normalizing effects on the physical metabolism in addition to analgesic action, the precise mechanisms of its action are still uncertain, it is also widely applied to treatment of arthralgia.
In this study, effects of acupuncture on 18 patients with knee osteo-arthritis (OA) were examined using gas analysis of the synovial fluid. Acupuncture needles were inserted into the “Zusanli” (F₆ 9) and “Xuehai” (F₁ 10) of the involved side and electrical stimulation with square wave pulses at 1Hz was applied through the needles for 30min. Two ml of synovial fluid was sampled from the knee joint using a heparinized syringe before and after the acupuncture, and partial pressures of CO₂ (PCO₂) and O₂ (PO₂) as well as pH of the samples were measured immediately by a gas analyzer, ABL30 (Radiometer, Copenhagen). Base excess (BE), total CO₂ density (TCO₂) and bicarbonate density (HCO₃) were calculated from these values using the equation of Siggaard-Andersen.
After the acupuncture, a significant (p<0.05) elevation of PO₂ in synovial fluid was observed, but no significant change was observed in PCO₂, pH, BE, TCO₂, and HCO₃. A significant (p<0.05) negative correlation was seen between the elevation of PO₂ and lowering of PCO₂ (r=0.4682). These results suggest that acupuncture may increase the local blood flow around the joint and thus may stimulate the metabolism and replacement of gas in synovial fluid. From the above, it is suggested that acupuncture is useful for treating arthralgia such as osteo-arthritis.

抄録全体を表示

We studied the effect of bath products consisting of sodium bicarbonate and sodium sulfate on living subjects when these products are used with herbal ginseng extract as a trial for a new bath product; changes in dynamic circulation were used as indicators.
Experiments were conducted from December 1990 to February 1991 on 20 subjects consisting of healthy male adults (35.6±8.9 years).
Two types of bath products were used. One consists of sodium bicarbonate and sodium sulfate and the other was the combination of the former with ginseng extracted by alcohol. Twenty five grams of each product was dissolved in 200 liters of water.
As indicators of dynamic circulation, skin surface temperature on thorax, abdomen, dorsal side of hand and dorsum of foot, volume of blood flow in leg skin (on tibia), deep body temperature in frontal region and right calf, electrocardiograph, blood pressure, and the volume of the pulsewave in the right index finger and big toe were measured. After the experiment, each subject's opinion was gathered through a questionnaire.
The experiment was performed in an air conditioned room (26°C and 50% humidity) with bathing at 41°C for 10 minutes. The value of each indicator was measured before bathing and 15, 30, 45, and 60min after bathing.
Although no significant differences in measured values were found between the two kinds of bathing, we observed faster decrease in skin temperature and faster lowering of blood flow rate in the ginseng bath group as compared with the control group. We also noted a decreased difference in pulsewave height between upper and lower extremities after bathing in the ginseng bath group, but not in the control group. This response was observed solely in the ginseng bath group because a significant increase in pulsewave height occurred in the big toe while no increase is observed in the fingers in contrast to the control group.
Faster decrease in blood flow rate in the skin and increase in pulsewave height caused by the exposure to the same temperature imply increased heat conducting distance and interruption of heat transfer from deep areas to the skin. We therefore conclude that ginseng bathing is effective in keeping the body warm. The results of inquiries after bathing indicated that many subjects felt that ginseng bathing tended to warm their bodies.
As a result of using ginseng extracted by alcohol with bath products consisting of sodium bicarbonate and sodium sulfate, differences in peripheral vessel resistance between extremities tended to decrease after bathing. We consider that this is due to the improved general circulation throughout the whole body.

抄録全体を表示

人工二酸化炭素浴剤浴での二酸化炭素の経皮吸収に関してウサギを用いて検討した。標識化合物として NaH¹⁴CO₃ を用い, コハク酸溶液との混合により製造した人工二酸化炭素泉浴 (40℃) をウサギ腹部に適用した。適用時の二酸化炭素濃度は約50ppmであった。適用後, 経時的 (0, 5, 10, 15, 20分後) に血液及び呼気中の二酸化炭素を採取した。また, 適用20分後の主要組織中濃度も測定した。
被験液適用5分後の血液及び呼気中にすでに放射能が検出され, 時間経過とともに漸次増加し, 適用20分後の血中濃度は22.0ng/g, 呼気中の二酸化炭素量は9.39μgに達した。適用20分後の主要組織中にも放射能が検出され, 適用20分後までの経皮吸収量は24.49μg, その吸収速度は244.9μg/m²/min (142.9μ1/m²/min) であった。温湯に溶解した二酸化炭素はウサギ皮膚より速やかに吸収され, ついで速やかに呼気中へ排泄されることがわかった。

抄録全体を表示

The purpose of this study was to clarify the effect of warm water bathing (40°C) of the hand on the psychologic sweating measured in the opposite palm. The subjects were 2 males and 4 females, aged 38±10 years (26-58 years). The psychologic sweating was estimated by the apparatus developed by Sakaguchi et al (Sakaguchi, M. et al BME 26: 213, 1988). The room temperature was 27 to 28°C and the relative humidity was 60 to 70%. The sensor was attached using adhesive tape on the right palm. Then the psychologic sweating was measured after deep respiration, mental arithmetic, hand grip, bathing in warm water of 40°C at the level of left wrist. The results showed that the mean values of palmar sweating were 15.6 for deep respiration, 16.8 for mental arithmetic, 15.5 for hand grip and 0 for warm water bathing.
Above results suggest that local water bathing of moderate temperature induces a decrease of psychologic sweating, probably due to relaxing effect of the cerebrum.

抄録全体を表示