In post-genome era, the greatest challenge of post-genome research is how we can apply genomic outcome to practical field like clinical medicine through discovering effective findings from its complex and meta-molecular network. From the viewpoint of reducing health care cost, preventive medicine that can avoid diseases should be essential target. Balneology that contains preventive medicine in part through unspecified bio-modulation effect should be a principal field of genome science based application. Balneology has expectations to be applied to practical clinical field or health promotion through translational research to modern medicine or health science. This translational research needs establishment of bridging knowledge and its bi-directional migration as the essence of translation. Integration of in silico knowledge among balneology, modern medicine, and genomic science is the fundamental basis of this translation. Single knowledge architecture that has anatomically hierarchical structure, logical conceptual unit and its supportive evidences makes integration logically seamless and establishes smooth translation. This paper reports knowledge architecture in balneologic translational research and its prototype.
It is well known that spa therapy is quite useful for the so-called life-style related diseases. It is therefore speculated that the number of aged people to be cared by the public insurance of elderly care may be less in spa districts than in non spa districts. As a matter of fact it was demonstrated in Oita prefecture that the number of aged people qualified for receiving the care was significantly less in Beppu city and Yufuin town which are well known as spa resort than in the surrounding non spa city or towns. This report is the result tallied up on the data from 38 prefectures all over Japan, regarding the number of aged people and hot springs. Although the ratio of number of aged people qualified for receiving the care to all aged people over 65 y-o is quite different among both the prefectures and the cities or towns under the same prefecture, the tendency of lower ratio in spa cities or towns than in the others was observed. It suggests the more prospective study is necessary on the effects of spa bathing on ADL disorders of aged people.