Anti-inflammation effect of artificial CO₂-bathing was confirmed on carrageenin induced edema experimentally using rats.
Artificial CO₂-bath was prepared with carbonated water by high pressure CO₂ bubbling and with a 50g tablet, made from sodium bicarbonate and succinic acid, putting simply in plain water.
Carrageenin induced edema was suppressed by plain water bathing, and was further enhanced at lower temperature.
It has been definitely shown that the edema is significantly suppressed with CO₂-bathing as compared to plain bathing due possibly to improved tissue perfusion.

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Sodium succinate is remained behind following artificial CO₂ bathing, prepared with a 50g sodium hydrogencarbonate and succinic acid tablet producing fine bubbles in water.
2NaHCO₂+(CH₂)₂→(COOH)₂→(CH₂)₂(COONa)₂+H₂O+CO₂
Na₂CO₃+(CH₂)₂(COOH)₂→(CH₂)₂(COONa)₂+H₂O+CO₂
Balneotherapeutic effect of sodium succinate was evaluated experimentally using 10 rabbits by means of medical mass spectrometry.
Subcutaneous PO₂ and PCO₂ did not change during the bathing and tissue perfusion of 21.30±3.48ml/100g/min (mean±standard error), SD=4.94, p<0.05 was evaluated at 36-37°C, demonstrating no significant difference compared with that of 20.85±3.56ml/100g/min, SD=6.71, p<0.05 by plain water bathing.
These data showed clearly that the balneotherapeutic effects of an artificial CO₂ bathing prepared with a CO₂-tablet, “BUB”-KAO, was not from organic salt of sodium succinate but from CO₂.

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The finger skin temperatures at ventral tip of both sides were examined in 8 normal subjects and 20 patients with vibration disorder, during one hand 45°C-water immersion test of 10 minutes.
In normal cases, the figer skin temperatures of the immersion side increased immediately and then waved from time to time during the immersion. The mean temperature at the time of 4.5 minutes was significantly higher than those of 2.5 minutes and 8.0 minutes and did not come near the 45°C graduary.
In the patients with vibration disorder who had got Raynauds' phenomenon with in a recent year, the skin temperatures did not so waved as which did in normal cases and became near the 45°C in the later half of the immersion. After the immersion, the warmed skin temperatures returned more slowly to their previous values than the normal cases.
The finger skin temperatures of the non-immersion side showed transient but significant falls initialy and then got up gradualy during the immersion in the normal cases.
In the patients with vibration disorder who had got Raynauds' phenomenon, within a recent year, the mean skin temperature of the non-immersion side was significantly lower than the normal value almost before, through and after the immersion especialy in the later half of the immersion and for several minutes after the immersion. The initial fall of skin temperatures were not so obvious as they were in the normal cases.
These data suggest that the hot water immersion test is useful to asess the peripheral circulatory disturbance in patients with vibration disorder.

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Fourty-four cases with psychosomatic disease or neurosis were studied during serial immersion in hot sulfate spring for 7 days at Sukawa Spa in Iwate prefecture. Before and after the balneotherapy, blood specimen were taken for endocrinological analysis of plasma catecholamines with use of high-speed liquid chromatography. One, two and three years after balneotherapy, long term prognostic efficacy was evaluated by questionnaire in order to examine the relationship between efficacy and changing pattern of plasma catecholamines.
The results of this study presented that the plasma levels of norepinephrine had decreased during balneotherapy in effective cases (p<0.05). Furthermore, the same changing pattern of plasma norepinephrine was observed in the cases which had improved after long interval. On the otherhand, in non-effective cases and cases with recurrence, the plasma levels of norepinephrine had increased significantly (p<0.05) during balneotherapy.
It was thought that response pattern of plasma catecholamines to serial immersion in hot spring reflected the therapeutic mechanism of balneotherapy, thus it would be an appropriate mediator for evaluating the prognosis.

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Records on every 6 hour symptom were kept for the period from July 15 through November 30, 1983 by 19, 19 and 26 patients who were outpatients at the Sapporo Civil Hospital, the University of Tokyo Hospital and the University of Ryukyu Hospital. Every 6 hour fluctuations in percentage of asthmatic symptoms were calculated from these records.
Meteorological conditions prevailing each city were classified into 9 patterns, i. e., west-high-east-low pattern, north-high pattern, south-high-north-low pattern, east-high-west-low pattern, ridge pattern, trough pattern (east-west), migratory anticyclone pattern, trough pattern (south-north) and tropical depression pattern.
An asthma frequency (AF)in days under a certain type of meteorological conditions was compared with that in all the other days. Asthmatic symptoms were more frequent in the days under west-high-east-low pattern and those under migratory anticyclone pattern were also higher. An AF in days under south-high-north-low pattern and that in days under trough pattern (east-west) were lower.
Most of days under west-high-east-low pattern were in late autumn in each of the 3 cities. The temperature of the days in Tokyo under this pattern were lower than the control days which belonged to the same period. Days under migratory anticyclone pattern were in the whole period of this study in Sapporo, in autumn in Tokyo and Naha. The temperature of these days in Sapporo and Tokyo was significantly lower than those of the control days.
Most of days under south-high-north-low pattern were in summer in each of the 3 cities. The temperature of the days in Tokyo under this pattern was significantly higher than those of the controls. Days under trough pattern (east-west) were from late summer to autumn in Naha. There was no difference in the temperature between the days under this pattern and the control days.
In summary, some of meteorological conditions had acute effects on asthma frequencies. When significant differences were observed in the temperature, it was lower (higher) in the days under a meteorological condition, under which the asthma frequency was high (low), than in the control days which belonged to the same period.

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