In order to clarify why orthopedic complaints such as lumbago are ameliorated by hot-spring bathing, serum levels of sialic acid and fucose, which form glycoconjugates and are markers of connective tissue metabolism, were measured before and after each hot-spring bathing. No changes were observed in serum sialic acid for persons who took hot-spring bathing more than three times per day for 10 days. However, many of them showed a decreasing tendency in serum fucose level after bathing. Although it is not clear why this tendency occurs, it strongly suggests that hot-spring bathing influences on connective tissue metabolism.
Effects of hypothermia on corticoidogenesis (CG) were investigated in primary cultured bovine adrenocortical cells. In order to evoke CG, adrenocorticotropic hormone (ACTH), dibutyryl cyclic AMP (db-cAMP), and high K+ were used. In the presence of the above mentioned secretagogues, cells were incubated at 37°C, 27°C, and 20°C for 1 hour. Although there was no difference between the ACTH-induced CGs at 37°C and 27°C, CG was significantly lower at 20°C. Both db-cAMP and high K+-induced CGs were significantly lower at 27°C, and were not observed at 20°C. These results indicate that CG is not affected by moderate hypothermia, and is not eliminated even by deep hypothermia. It is also suggested that ACTH influences not only adenylate cyclase and Ca2+ channels, but also various processes of glucocorticoid production and could evoke CG at 20°C in bovine adrenocortical cells.
To find the correlation between the thermal action of hot bathing and the induction of heat-shock proteins (HSP), spontaneously hypertensive rats (SHRs) and normal Wistar rats were subjected to bathing experiments. Tests were also conducted to determine whether two kinds of HSP molecules, HSP 70 and HSP 90, were induced in the brain, liver, and kidneys, and inductive specificities were quantitatively investigated in SHRs. Both SHRs and normal rats of the hot-spring bathing group showed more potent induction of HSP 70 and HSP 90 at ages of 10 weeks and 26 weeks than the values in those of the plain-water bathing group. Among SHRs, HSP 70 and HSP 90 decreased in the brain and liver at the age of 26 weeks as compared with those at the age of 10 weeks (with HSP 70 in the brain reduced to half). HSP 70 increased in the kidneys, with HSP 90 hardly detectable. Among normal rats, HSP 70 and HSP 90 decreased in the brain, liver, and kidneys, but the rate of decrease was not so remarkable as in SHRs. The results suggest that the inhibitory effects of hot-spring bathing on blood pressure of SHRs are closely related to the decrease in the rate of induction of HSPs.
More than 30 years have passed since the emergence of many patients with what is now called vibration syndrome. We have been engaged in vibration syndrome therapy since 1973 using thermotherapy, therapeutic exercise, and herbal medicine. We have measured the skin temperature of both middle fingers of patients every year in spring and autumn. In 1985, 12 years after starting the treatment, we noted significant improvement in their skin temperatures. This paper is a report on the changes in skin temperature as measured over 10 years (from 1980 to 1990) in ten patients with Raynaud's phenomenon. From our study, we have concluded that a period of 10 years or more is required to treat patients with Vibration Syndrome.