NS 2662,
O, O-dimethyl dichlorohydroxyethyl phosphonate, and trichlorfon were effective to chewing insects but not to sucking insects. Topical toxicities, distribution, metabolism and
in vitro cholinesterases inhibition of these insecticides were examined with larvae of rice stem borer,
Chilo suppressalis WALKER and of tobacco cutworm,
Spodoptera littoralis BOISD., and adults of American cockroach,
Periplaneta americana L., house fly,
Musca domestica vicina MACQ., green rice leafhopper,
Nephotettix cincticeps UHLER, black rice bug,
Scotinophara lurida BUR. and corbett rice bug,
Leptocorixa corbetti CHINA. Permeability of cuticle, distribution in the various tissues and penetration into the dissected thoracic ganglions of
32P-NS 2662 and
32P-trichlorfon were not different between susceptible and non-susceptible insects. A good correlation was found to exist between degradation of these insecticides and susceptibility of insects to the insecticides. Cholinesterase sensitivity of these insects was examined for NS 2662, trichlorfon and their vinyl phosphate derivatives, and it was found that cholinesterase sensitivity was not parallel to topical toxicities. Selective toxicity of NS 2662 and trichlorfon may be explained in part by the difference in degradation rate of the insecticides among these insects.
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