Evaluation of the subjective quality of life in patients with Parkinson's disease Hiroaki Takeuchi, MD, PhD, Michiko Mino, RN, Hiroko Kunikata, RN Satoshi Fujimoto, RN, Hisae Ito, RN
Subjective quality of life (QOL) is increasingly recognized as an important outcome variable of medical care, particularly for chronic neurological diseases such as Parkinson's disease (PD). Subjective well-being was evaluated in 67 PD outpatients (age: 67.2±7.0 S.D., range 49-83 years) using a 27 item QOL rating scale, newly developed by the Ministry of Health and Welfare of Japan. A activities of daily life (ADL) was also assessed by the Barthel Index (B.I.). Patient's utilization of the social resource services consisting of 15 items such as "day care" and "home help" was scored as 0, 1, or 2 points according to degree of utilizaion. The following results were obtained. The mean QOL score was 31.7±10.3 S.D. (54)*, and the mean B. I. score was 91.5±17.3 S.D.(100)* (B. I. 100, n=36, less than 100, n=31).
The number of patients receiving a utilization score of 2 points was comparatively high for several items such as "patients' organization" (56.7%), "official note of disabilities" and "house adaptation". Social resource services utilization scores for disabled patients (11.7±5.4 S.D.) were significantly higher than those for non-disabled patients (8.8±4.8 S.D., p<.05). These scores also showed a high correlation with disease duration (r=.48, p<.0001).
QOL scores for non-disabled patients (34.6±11.5 S.D.) were significantly higher than those for disabled patients (28.4±7.7 S.D., p<.05). QOL scores significantly decreased with increased in the Hoehn & Yahr Staging Scale (p<.05).
The overall scores, current age, onset age, disease duration, Barthel Index, social resource services utilization score, Hoehn & Yahr Staging Scale, and QOL score were statistically analyzed. Forward stepwise regression analysis revealed that the multiple regression function: (QOL scores)=39.004-5.808 (Hoehn & Yahr Staging Scale)+0.59 (social resource services utilization score) was useful for estimating the QOL score in PD (F-to-Enter 4.000, Adjusted R Squared.19, p=.0004). The results of this study indicate that physical impairment and social resource services are important impact factors affecting the subjective QOL outcomes in PD.
* Maximal score possible on this scale.
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