A survey was conducted on 2837 male and 2706 female subjects, aged 6 to 14 years and residing in urban, suburban and rural communities in Saga Prefecture in an aim to see the possible relationship existing between the subject's occupation and his tooth caries experience. The numbers of def teeth, DMF teeth and DMF index were respectively examined on each subject and comparison of the caries incidence between different occupational groups was made on the basis of the mean ratios of differences. The results have shown that tooth caries was most prevalent in the agricultural population, followed by trading and salaried people almost at the same level of incidence between them, and tooth caries was least prevalent in the mine population. Although there were indications pointing to the close relationship existing between tooth caries and the subject's occupation, it has been also noticed that the disease was greatly dependent on the individual's mode of food intake, or to say more particularly, on the amount of sugar consumed by him.

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Cryptococcus neoformans was isolated from cerebro-spinal fluid of a patient of cryptococcosis. Rats, and 65 mice were sacrificed for experiment. We divided these mice into three groups ; 0.3 million cells of cryptococcuci were inoculated intracereberally in 15 mice of MA group. 15 million intraperitoneally, in 15 mice of MB group, 6 million intraperioneally in 15 mice of MC group. We investigated the changes mycologically, clinically, pathoanatomically and pathohistologically etc., Results obtained were as follows ; 1) The micro-organisum isolated from cerebro-spinal fluid of a patient was mycologically Cr. neoformance. 2) The mice of MA group died on the 2nd∿the 7th day after inoculation (average life ; 5.1 days), MB group died on the 3rd∿the 15th day (average life ; 7.9 days), MC group died on the 4th∿the 30th day (average life ; 12.6 days). 3) The clinical findings of mice of every group exhibited a sort of sneezing, exophthalmus, inactivity, want of appetite, anorexia, hypersensibility, senseless, tremor, paralysis, force posture, forced movement, asthenie and coma, ctc. 4) As a patho-anatomical findings, there were a lot of poppy-seed great milky white round or oval lesions in central nervous system, heart, lungs, liver, spleen and kidneys of every group. These lesions were sharply circumscribed. There was no inflammatory reaction around the lesion. a) In MA group, there was no jelly-like substance around the inoculated portion of the meninx. There was no inflammatory reaction everywhere. Liver and spleen showed slight stagnation. Liver and kidney showed slight cloudy swelling. b) There was no considerably much jelly-like substance on the surface of intestines, and mesenterium around inoculated portion. Such substance was easily desquamable by finger. No inflammatory change was found on peritoneum. Other changes were almost similar to that of MA group. 5) Patho-histological findings ; A lot of poppy-seed great lesions in central nervous system, heart, lungs, liver, spleen, kidneys and intestinal tubes was microscopically a kind of cyst. The destruction and the number of lesion revealed the extensive evidence in central nervous system, but those of other organs were more inferior to the former. The lesions of central nervous system in every group were almost identical, in MA group there were many cyst whose diameter measured 300μ∿1300μ, and in MB and MC group there was no cyst whose diameter measured over 400μ. The shape of cyst in all groups was round or oval. The wall of every cyst was distinctly limited. There was no tissue reaction or no exsudation around the lesion. Cyst contained some cryptococcuci and some mucoid substances in it. There was many buddings of cryptococcuci in central nervous system, heart, but there was no in other organs. The lesions which had no inflammatory reaction or no exsudation inspite of presence of destructive changes were characteristic feature in cryptococcosis. The histological findings of central nervous system of all groups showed almost the same changes. There were many cysts of various size in cortex, medulla, telencephalon, diencephalon, rhonbence-phalon and spinal cord. Various nerve-cells showed swelling or atrophy, degeneration and destruction. Neurits showed also myelin degeneration, atrophy or destruction. Cryptococcuci were found in various organs separatedly, and there were remarkable number of cryptococcuci on the surface of plexus cholioideus and subarachinoidial spaces. The jelly-like substance in abdominal cavity of MB, MC group was collection of cryptococcuci. In every group, there were degeneration of heart muscle, stagnation of lungs, liver and spleen, and cloudy swelling of liver. The glomeruli showed the destructive changes. The epithel cells of nephron were severely degenerated. 6) Patho-chemical findings ; By Menkin's method, we examined Leukotaxine and Capillary Promoting

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A survey on the status of occupational injuries among workers of yawata Iron & steel, Inc. has that revealedoral injuries occupied about 1% of the total, the actual number decreased yearly approximately in proportion to the decrease of the total number of injury. Seasonally, these accidents took place more freguently in cold season extending from November to May, than in other months of the year, and the most frequent hours of the day for them to occur were from 9 to 12 o'clock a. m. when workers were busily engaged in their duty and from 1 to 3 o'clock p. m. when they were appointed for work shift. The most frequent age stage of the subjects to suffer the injuries was the twenties, followed by the thirties and then the forties. From the view point of service year of the subjects, those who served from 2 to 4 years were most busily to suffer the injuries. Of the causes of she injuries, bruies ranked first with 78.6% of the total, followed by tumble aud fall. In oral injuries the tooth damage occupied 84.3%, the mandibular fracture 9.2% and the soft tissue damage 6.2%, the tooth damage occured in the upper jaw 74.1% and especially in the central and lateral incisors.

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A statistical survey was conducted on a total of 49720 pupils from 6 to 14 years of age, residing in Fukuoka Prefecture and being composed of 13518 males and 12505 females of urban, and 12187 males and 11510 females of suburban districts, and comparison was made between two district groups of population with regard to the developmental phase in body height and weight. The data thus obtained were also compared with those from the corresponding subject groups in the corresponding districts in Fukuoka Prefecture as obtained in 1948. The results were as follows. 1) For the year 1959 A Comparison of body height between sexes Urban district : male > female Suburban district : male &ge; female Comparison between the district groups Male : urban ≧ suburban Female : urban < suburban B Comparison of body weight between sexes Urban : male < female Suburban : male < female Comparison between the district groups Both sexes : urban > suburban 2) Comparison between 1959 and 1948 A Body height Urban as well as suburban district groups of both sexes excelled in 1959 than in 1948 B Body weight Urban as well as suburban district groups of both sexes excelled in 1959 than in 1948. Body height in 1959 of all the subject groups excelled considerably that in 1949 with the mean increment of respectively 1.1 to 2.6cm in six years of age, 3.0 to 8.1cm in 7 to 10 years of age and 6.3 to 20.9 cm in 11 to 14 years of age of the subjects. The increase was especially noted in the middle school pupils. In the body weight of all the subject examined, the average figures for the year 1959 excelled those for the year 1948 by respectively 0.3 to 0.6 kg in 6 years of age, 1.6 to 3.4 kg in 7 to 10 years of age and 2.1 to 14.7 kg in 11 to 14 years of age of the subjects regardless of sexes and districts concerned. 3) The marked increase in the body height and weight of the sudjects in the year of 1959 may be accounted for by the increased supply of staple food with accompanying improvement of nutritional status of these people as compared to the postwar condition and also by encouragement of sports for these people. More maked acceleration in the develoment of female physique as compared to male may also be accounted for by masculinization of sports for the female, elimination of feminine inferiority complexes and by improvement of female clothing and school ration as attained in these days.

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A 15 months old female Indian Elephant followed down suddenly on bord after two months voyage from Bankok. Clinical diagnosis was acute pneumonia. Various antibiotics were used but she died at last on 30th Nov. 1954. We disected her 13 hours after death. The results obtained were as follows ; A) Pathologic findings ; 1) Bronchopneumonia 2) Rharyngitis 3) Glottisoedema 4) Pharyngitis 5) Tonsilitis 6) Ulcers and catarrh of the stomach, gastorophyli equi (about 200) 7) Ulcers and catarrh of the intestine, two tenias and gastolophyli equi 8) Claudy swelling and stagnation of the liver, a kind of trematode 9) Glomerulonephritis 10) Stagnation of the spleen 11) Cystitis 12) Atrophia galletinosa of the pericardial fatty tissue 13) Dermatitis pulurenta (neck, right behind leg, right side of the head) 14) Bleedings (traumatic bleeding of the left neck, stomach, intestine) 15) Fracture of the left ivory. B) Dental formular should be F1/0, M1/1=6 (but mollar teeth changs 5 times through life).

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著者等は某セメント工場の採砿夫、運搬夫、砕石夫等の男154名、女19名、計137名について重心の計測を行った。重心高は身長、体重に密接な関連を有するものであるが、職種及び年令層別において男は約91&acd;93cm、女は85&acd;87cmである。しかし比重心高はほぼ一定した約57の値を得た。

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In the mycological investigation, tow varieties of organisms or more caused of mixed infections were isolated from fungus diseases as the lesions or only parasites of healthy human body, in such a consideration was not yet paid too much attention. The authors had isolated many strains of genus Candida and the other yeast like fungi from vaginal cavities of sixty gynecological patients. In a half of 60 patients, we have found many yeast like colonies forming on a Sabouraud's agar plate that were isolated from each of material, we picked ten colonies up from one plate of each cases without selection, and investigated cultural and biological properties of various colonies. The results of the experiments are summerized as follows. 1. The authors found single parasite of Candida or yeast like fungi in 19 cases of 30 patients. 2. Co-existent parasites were found in 11 cases ; Candida albicans and the yeast like fungi in 5 cases, Candida albicans, the other species of Candida and the yeast like fungi in 3 cases, Candida albicans and the other species of Candida in 2 cases and in the last of one case, we found the other spcies of Candida (except Candida albicans) and the yeast like fungi.

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A woman aged 62 suffered from salvarsan toxication after 13 injections and showed clinically edema of the face and under parts of legs, severe ulcerative stomatitis and pigmentation of oral mucous membrane. The doctor gave up injection of salvarsan and treated her with various methods for salvarsan toxication, but she died at last after about two months. We dissected this corpse and obtained folowing findings. 1) Marasmus. 2) Fatty degeneration and atrophy of liver. 3) Nephrosis. 4) Ulcerative stomatitis and pigmentation of oral mucous membrane. 5) Bleeding of palms and under parts of nails. 6) Arteriosclerosis. 7) Dilation of right ventricle. 8) Dilation of stomach. 9) Adhession of right pleura. 10) Malformation of right lungs (2 lobi). 11) Regressive changes and dark braun pigmentgranulas in liver, kidneys, suprarenal body, heart muscls, brain and spinal cord. 12) In gingival tissue and tongue, degeneration or necrosis of epithels, perivasculary inflammatory cells emigration and pigmentation in the submucosa were seen. 13) Degenerative change of N. mandibularis were recognized.

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An Aspergillus, strain G-16 which had the growth-promoting effects on Candida have been isolated from the air and the experimental results of this promoting effects of the strain G-16 were summerized as follows. 1. The growth-promoting effects of the strain G-16 on Candida were observed in all 7 species of the Candida, however there are some differences of effects among the species. 2. In the assay, production and purification of the growth-promoting substance, GS (Glucose-Simmons) medium was most favorable results when the strain G-16 was cultivated in the pH 7.0, at 25℃ for 7th day. 3. The growth-promoting effects were slightly heat stable and effected at neutral in the pH. This growth-promoting subatance was dialysed with membrane of cellophane and filtered with Chamberland L_3, such evidence proposed a suggestion of the substance of lower molecular. 4. This growth-promoting substance was not dissolved into ether, and absorbed with active carbon and partially dissolved into aceton from carbon which absorbed promoting substance.

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The species of the pathogneic fungi have been diagnosed only on the basis of morphological aspect, especially of their colonial forms. The study of dissociation and variation is necessary to identify and classify the pathogenic fungi, according to one species has several morphological forms. The author have studied the causing of dissociation of the Rough form of colonies (so called "membranous variants" with Mackinon) that happened the appearance of variants on Sabouraud's glucose agar in Candida albicans. I have fixed two types of variants so called Smooth and Rough forms of colonies with one strain of Candida albicans and had comparative investigations of cultural, fermetatvie and antigenic properties between those two types of variants. The results of experiments are summarized as follows : 1. The great causing to arise dissociation of the S-R form are lack of carbohydrate, contained in the medium. And due to the higher pH of culture medium (from pH 7.2 to the Alkaline side), and it rapidly tended to dissociate by heating the culture medium in the same range of pH. 2. Morphological properties. -The S form on Sabouraud's glucose agar have not tendency toward R form in the young culture but it became intermediate form between the S and R form in the adult culture. The R form variants are sufficiently fixed to be considered as true variants. 3. Biochemical properties. -The R form variant ferments the same sugars as the S form. 4. In antigenic properties, the R form variants are observed with decrease of somatic polysaccharide-containing antigen and diminution or total loss of production of the antibody. 5. Reversion from the R form to the S form, it is possible to have obtained by rapid transfers (15-20 transfers) of the R form variants through a highly nourishing media (3% glucose Sabouraud's broth or agar) at pH 4.0.

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The author have been observed tow types of colonial variants which were named the mycerial type and the blastospore type in Candida albicans on the corn meal starch agar and had comparative investigations in those two colonial variants. The results of experiments are summarized as follows. 1. On Sabouraud's glucose agar, there were no differences in morphological aspects of the cultures between the mycerial and blastospore types, and both of variants made creamy normal forms. 2. In several cultural and fermentative properties with classification by Martin and others there were not any recognizable changes between mycerial and blastospore types, and were also observed the same results as in the other experimental properties (heat sensitivity, resitance to disinfectants, pathogenicity and antigenicity.) 3. In the chlamydospore formation, were observed that mycerial types easily developed the chlamydospores but difficult in the blastospore types.

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昭和32年熊本県天草島(上島、下島)に於ける4地域(本渡、二江、一町田、栖本)の小学校児童を対称とし歯牙交換期に就て調査し、先人の業績との比較を試みたところ次の如き結果を得た。乳歯の脱落期 1.性別及び顎別に於ては女が男より早く、男女とも下顎は上顎より早い。2.脱落順序は男女の上顎、男の下顎はA、B、D、C、Eの順で、女の下顎はA、B、C、D、Eの順である。3.文献との比較乳臼歯部が上下顎とも荷宮のものより半年から1年早いが最近の木下、島村のものより、同期間逆に遅れている。永久歯の生歯期 1.性別及び顎別に於て女は男より早く、下顎は上顎より早い。2.萌出順序は男女とも上顎は6124357の順で、下顎は6124357の順である。3.文献との比較男女の上下顎とも切歯及び第1大臼歯は荷宮のものより遅れているが、小臼歯は逆に早く、島村の農村(大曲)と新藤の中都市(徳山)との中間位を示した。

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