In order to analyze the influence of thyrotropin releasing hormone (TRH) on rehabilitation process of stroke Patients, the comparison of functional gain and length of hospital stay was made between eight patients treated with TRH (TRH group) and 11 age and sex matched ones without TRH (control group). Using Social Maturation Scale (Takenshiki, SMS) and Motor Age Test for trunk and lower extremities (MoA), the patients were assessed at the admission, 2 and 3 months after the admission and the discharge, respectively. TRH of 2mg was administered once a day by intravenous drip injection for 10 days between 2 and 3 months after the admission. The gain of SMS score between 2 and 3 months after the admission was larger in the TRH group than in the control group, especially that of interpersonal skills. The gain of MoA score was not different between the two groups. Compared to the control group (5.3 months), the length of hospital stay was significantly short in the TRH group (4.2 months). However, functional gain during inpatient-rehabilitation was not different between the two groups. It is assumed that TRH is effective to shorten the course of stroke rehabilitation.

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Viability of C. trachomatis in thermal waters collected from 5 spas was examined by inclusion forming ability in HeLa cells. In the acid springs (pH 2.0-2.2), the organisms lost their infectivity within 0.5hr when they were incubated at 37°C and no inclusion were detected when incubated at 42°C. In weak alkaline springs (pH 8.0-8.8), the organisms could be detected after incubation at 37°C for 2hr or at 42°C for 1hr, but number of inclusions were significantly decreased.

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The effects of single bathing of the artificial mineral spring (Basukurin: Tsumura Juntendo Inc. Japan), equivalent mixture of sodium sulfate and sodium bicarbonate, were studied in 13 normal and 22 hypertensive subjects comparing with natural simple hot spring (Kirisima spa).
Blood pressure (BP: automatic sphygmomanometer), heart rate (HR), cardiac output (CO: earpiece type dye-dilution densisometer), total peripheral resistance (TPR: mean BP/cardiac index), forehead deep body temperature (DBT: Core Temp CTM 204) plasma renin activity (PRA: RIA by Habar's method), plasma norepinephrine (NE) and blood gas partial pressure (pO₂ and pCO₂) and pH were measured before and after bathing. Mineral concentration of simple hot spring and Basukurin bath (120g powder/360l simple hot spring) were 0.019% and 0.052%, respectively. The temperature and duration of bathing were both 41°C for 10min.
In normotensives, only systolic BP and TPR were significantly decreased 30min after the simple and Basukurin bathing by the same degree. HR was significantly increased throughout 30min after both bathing. CO was increased only after 10min of Basuku rin bathing. In hypertensives, systolic and diastolic BP and TPR were significantly decreased throughout 30min after simple and Basukurin bathing. The decrement in BP and TPR, however were significantly greater in Basukurin bathing. HR and CO were significantly increased after both bathing. Forehead DBT was significantly elevated after both bathing and gradually decreased throughout 30min of observation. In Basukurin bathing, although the increment in DBT was greater than simple hot spring bathing, the decrease was slower than simple hot spring bathing suggsting the protection from heat radiation by Basukurin bathing. PRA and plasma NE concentration examined in hypertensive subjects after 30min of bathing were significantly elevated only in Basukurin bathing. Although arterial gas concentration and pH were not changed after bathing, venous blood pO₂ and pH were significantly increased and pCO₂ was significantly decreased after 10min of Basukurin bathing.
These data indicates that single Basukurin bathing has more potent hypotensive effect due to vasodilation than simple hot spring. Enhanced vasodilation by Basukurin bathing is probably derived from the protection of heat radiation from the skin by the formtion of thin mineral film on the skin. Increased venous blood pO₂ and pH and decreased pCO₂ represents also the improvement of peripheral circulation assisted by vasodilation and elevated CO.

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For the purpose of estimating the analgesic mechanisums of the electroacupuncture stimulation and relating the adrenocortical function with its analgesic effect, the deviation value of the pain threshold by the stimulation and β-endorphin, Met-enkephalin lebels in the cerebrospinal fluid [CSF] and also cortisol lebel in the blood were observed in experimented dogs.
The both lebels of CSF and cortisol lebel in blood were significantly increased by the electroacupuncture analgesia. These result suggest that in this analgesia, the hypophysis-adrenal cortex system was activated simultaneously with the production of an endogeneous opiate. Using a new designed pain meter system [non-contact thermal stimulator] for the small animals, increasing of the pain threshold lebels was observed objectively.

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Muscle contraction headache is often treated in Oriental medicine. There are, however, many problems in its diagnosis and therapy. In the present study, the pulse waves of the digital apical and the shallow temporal arteries of correspond to the way were observed and compared with those in healthy controls.
As a result, the height of the pulse was found to be markedly lower in patients than in controls. When these patients were treated by acupuncture, headache was improved, with the pulse height returning to the level for healthy persons.
Thus, observation of pulse waves of the digital apical and shallow temporal arteries of correspond to the way provides a useful criterion for the diagnosis of headache of this type. It can also serve as an index for judging the efficacy of treatment by acupuncture and moxibustion.

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Muscle contraction headache is commonly treated in Oriental medicine, but there are various clinical problems involved. In the present study, electromyograms obtained at muscle fibers in the frontal belly and trapezius in patients with such headaches were compared with those in healthy controls.
Electrical discharge from the upper muscle fibers of the trapezius was increased in patients during exercise of the neck and the Amefuri test. In contrast, there was no difference in findings at the frontal belly between patients and controls. When the patients were treated by acupuncture, headache improved, and the pattern of electrical discharge from muscle fibers approximated to that for healthy controls.
Thus, observation of electromyograms at the upper muscle fibers of the trapezius provides a useful criterion for diagnosing headache of this type and can serve as an index for judging the efficacy of treatment by acupuncture and moxibustion.

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